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Complete atrioventricular block (cAVB) and residual shunting are major concerns during follow-up, but long-term data for both are still limited. We retrospectively evaluated the outcome of patients with interventional VSD closure and focused on long-term results (&gt;\u20091\u00a0year follow-up). Transcatheter VSD closures were performed between 1993 and 2015, in 149 patients requiring 155 procedures (104 perimembranous, 29 muscular, 19 residual post-surgical VSDs, and 3 with multiple defects). The following devices were used: 65\u2009\u00d7\u2009Amplatzer<jats:italic>\u2122<\/jats:italic>Membranous VSD Occluder, 33\u2009\u00d7\u2009Duct Occluder II, 27\u2009\u00d7\u2009Muscular VSD Occluder, 3\u2009\u00d7\u2009Duct Occluder I, 24\u2009\u00d7\u2009PFM-Nit-Occlud\u00ae, and 3\u2009\u00d7\u2009Rashkind-Occluder. The median age at time of implantation was 6.2 (0.01\u201366.1) years, median height 117 (49\u2013188) cm, and median weight 20.9 (3.2\u2013117) kg. Median follow-up time was 6.2 (1.1\u201321.3) years and closure rate was 86.2% at last follow-up. Complications resulting in device explantation include one case of cAVB with a Membranous VSD occluder 7\u00a0days after implantation and four cases due to residual shunt\/malposition. Six (4%) deaths occurred during follow-up with only one procedural related death from a hybrid VSD closure. Overall, our reported results of interventional VSD closure show favorable outcomes with only one (0.7%) episode of cAVB. Interventional closure offers a good alternative to surgical closure and shows improved performance by using softer devices. However, prospective long-term data in the current era with different devices are still mandatory to assess the effectiveness and safety of this procedure.<\/jats:p>","DOI":"10.1007\/s00246-020-02456-2","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T10:02:42Z","timestamp":1601719362000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Short- and Long-term Outcome After Interventional VSD Closure: A Single-Center Experience in Pediatric and Adult Patients"],"prefix":"10.1007","volume":"42","author":[{"given":"M.","family":"Bergmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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