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The objective of this study was to determine whether the ASO could be performed in a healthy animal model. Cardiopulmonary bypass (CPB) and coronary translocation techniques were used to perform ASO in neonatal piglets or a staged ASO with prior main pulmonary artery (PA) banding. Primary ASO was performed in four neonatal piglets. Coronary translocation was effective with angiograms confirming patency. Piglets could not be weaned from CPB due to right ventricle (RV) dysfunction. To improve RV function for the ASO, nine piglets had PA banding. All survived the procedure. Post-banding RV pressure increased from a mean of 20.3\u2009\u00b1\u20092.2\u00a0mmHg to 36.5\u2009\u00b1\u20097.3\u00a0mmHg (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). At 58\u2009\u00b1\u20091\u00a0days post-banding, piglets underwent cardiac MRIs revealing RV hypertrophy, and RV pressure overload with mildly reduced RV function. Catheterization confirmed RV systolic pressures of 84.0\u2009\u00b1\u20096.7\u00a0mmHg with LV systolic pressure 83.3\u2009\u00b1\u20096.7\u00a0mmHg (<jats:italic>p<\/jats:italic>\u2009=\u20090.43). The remaining five PA banded piglets underwent ASO at 51\u2009\u00b1\u20090\u00a0days post-banding. Three of five were weaned from bypass with patent coronary arteries and adequate RV function. We were able to successfully perform an arterial switch with documented patent coronary arteries on standard anatomy great vessels in a healthy animal model. To our knowledge this is the first time this procedure has been successfully performed. The model may have implications for studying the failing systemic RV, and may support a novel approach for management of borderline, pulsatile left ventricles.<\/jats:p>","DOI":"10.1007\/s00246-020-02507-8","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T08:07:31Z","timestamp":1606723651000},"page":"501-509","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Porcine Model of the Arterial Switch Operation: Implications for Unique Strategies in the Management of Hypoplastic Left Ventricles"],"prefix":"10.1007","volume":"42","author":[{"given":"Anthony","family":"Azakie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-7764","authenticated-orcid":false,"given":"John P.","family":"Carney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Lahti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle J.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy M.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"2507_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.athoracsur.2007.04.102","volume":"84","author":"ZA Qamar","year":"2007","unstructured":"Qamar ZA, Goldberg CS, Devaney EJ, Bove EL, Ohye RG (2007) Current risk factors and outcomes for the arterial switch operation. 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The authors alone are responsible for the content and writing of the article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval was obtained from the laboratory\u2019s Institutional Animal Care and Use Committee (IACUC) prior to the start of the experiment. All applicable international, national, and institutional guidelines for the care and use of animals were followed during this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All authors grant their consent to publish the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human and Animal Participants"}}]}}