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Exercise tolerance is determined with cardiopulmonary exercise testing by peak oxygen uptake (VO\n                    <jats:sub>2peak<\/jats:sub>\n                    ). Unlike VO\n                    <jats:sub>2peak<\/jats:sub>\n                    , the oxygen uptake efficiency slope (OUES) does not require a maximal effort for interpretation. The value of OUES has not been assessed in a large group of patients after ASO. The purpose of this study was to determine OUES and VO\n                    <jats:sub>2peak<\/jats:sub>\n                    , evaluate its interrelationship and assess whether exercise tolerance is related to ventricular function after ASO. A cardiopulmonary exercise testing, assessment of physical activity score and transthoracic echocardiography (fractional shortening and left\/right ventricular global longitudinal peak strain) were performed to 48 patients after ASO. Median age at follow-up after ASO was 16.0 (IQR 13.0\u201318.0) years. Shortening fraction was normal (36\u2009\u00b1\u20096%). Left and right global longitudinal peak strain were reduced: 15.1\u2009\u00b1\u20092.4% and 19.5\u2009\u00b1\u20094.5%. This group of patients showed lower values for all cardiopulmonary exercise testing parameters compared to the reference values: mean VO\n                    <jats:sub>2peak<\/jats:sub>\n                    % 75% (95% CI 72\u201377) and mean OUES% 82(95% CI 77\u201387); without significant differences between subtypes of TGA. A strong-to-excellent correlation between the VO\n                    <jats:sub>2peak<\/jats:sub>\n                    and OUES was found (absolute values:\n                    <jats:italic>R<\/jats:italic>\n                    \u2009=\u20090.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; normalized values:\n                    <jats:italic>R<\/jats:italic>\n                    \u2009=\u20090.79,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No correlation was found between cardiopulmonary exercise testing results and left ventricle function parameters. In conclusion, OUES and VO\n                    <jats:sub>2peak<\/jats:sub>\n                    were lower in patients after ASO compared to reference values but are strongly correlated, making OUES a valuable tool to use in this patient group when maximal effort is not achievable.\n                  <\/jats:p>","DOI":"10.1007\/s00246-021-02554-9","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T14:42:19Z","timestamp":1612190539000},"page":"866-874","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oxygen Uptake Efficiency Slope is Strongly Correlated to VO2peak Long-Term After Arterial Switch Operation"],"prefix":"10.1007","volume":"42","author":[{"given":"Covadonga","family":"Terol Espinosa de los Monteros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel L. 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