{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:06:12Z","timestamp":1740107172661,"version":"3.37.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00246-021-02598-x","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T12:04:35Z","timestamp":1618833875000},"page":"1170-1179","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perioperative Opioid Consumption is Not Reduced in Cyanotic Patients Presenting for the Fontan Procedure"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-143X","authenticated-orcid":false,"given":"Teresa M.","family":"Murray-Torres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Tobias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Winch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"issue":"21","key":"2598_CR1","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1056\/NEJM198711193172105","volume":"317","author":"KJ Anand","year":"1987","unstructured":"Anand KJ, Hickey PR (1987) Pain and its effects in the human neonate and fetus. N Engl J Med 317(21):1321\u20131329","journal-title":"N Engl J Med"},{"issue":"2","key":"2598_CR2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1001\/archpedi.152.2.147","volume":"152","author":"SJ Weisman","year":"1998","unstructured":"Weisman SJ, Bernstein B, Schechter NL (1998) Consequences of inadequate analgesia during painful procedures in children. Arch Pediatr Adolesc Med 152(2):147\u2013149","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"S3","key":"2598_CR3","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1097\/PCC.0000000000000619","volume":"17","author":"SS Lucas","year":"2016","unstructured":"Lucas SS, Nasr VG, Ng AJ, Joe C, Bond M, DiNardo JA (2016) Pediatric Cardiac Intensive Care Society 2014 consensus statement: pharmacotherapies in cardiac critical care: sedation, analgesia and muscle relaxant. Pediatr Crit Care Med 17(S3):S3\u2013S15","journal-title":"Pediatr Crit Care Med"},{"issue":"5","key":"2598_CR4","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/j.1460-9592.2010.03460.x","volume":"21","author":"AR Wolf","year":"2011","unstructured":"Wolf AR, Jackman L (2011) Analgesia and sedation after pediatric cardiac surgery. Pediatr Anesth 21(5):567\u2013576","journal-title":"Pediatr Anesth"},{"issue":"1","key":"2598_CR5","doi-asserted-by":"publisher","first-page":"e000046","DOI":"10.1136\/bmjpo-2017-000046","volume":"1","author":"GA Zeilmaker-Roest","year":"2017","unstructured":"Zeilmaker-Roest GA, Wildschut ED, van Dijk M, Anderson BJ, Breatnach C, Bogers AJ, Tibboel D (2017) An international survey of management of pain and sedation after paediatric cardiac surgery. BMJ Paediatr Open 1(1):e000046","journal-title":"BMJ Paediatr Open"},{"issue":"3","key":"2598_CR6","first-page":"610","volume":"40","author":"FG Iodice","year":"2011","unstructured":"Iodice FG, Thomas M, Walker I, Garside V, Elliott MJ (2011) Analgesia in fast-track paediatric cardiac patients. Eur J Cardiothorac Surg 40(3):610\u2013613","journal-title":"Eur J Cardiothorac Surg"},{"key":"2598_CR7","doi-asserted-by":"crossref","unstructured":"Roy N, Parra MF, Brown ML, Sleeper LA, Nathan M, Sefton BA, Baird CW, Mistry KP, Del Nido PJ (2019) Initial experience introducing an enhanced recovery program in congenital cardiac surgery. J Thorac Cardiovasc Surg 160(5):1313\u20131321","DOI":"10.1016\/j.jtcvs.2019.10.049"},{"issue":"1","key":"2598_CR8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.4103\/aca.ACA_113_18","volume":"23","author":"JP Iguidbashian","year":"2020","unstructured":"Iguidbashian JP, Chang PH, Iguidbashian J, Lines J, Maxwell BG (2020) Enhanced recovery and early extubation after pediatric cardiac surgery using single-dose intravenous methadone. Ann Card Anaesth 23(1):70","journal-title":"Ann Card Anaesth"},{"issue":"15","key":"2598_CR9","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.2217\/pgs.12.152","volume":"13","author":"S Sadhasivam","year":"2012","unstructured":"Sadhasivam S, Chidambaran V (2012) Pharmacogenomics of opioids and perioperative pain management. Pharmacogenomics 13(15):1719\u20131740","journal-title":"Pharmacogenomics"},{"key":"2598_CR10","doi-asserted-by":"publisher","DOI":"10.1177\/0885066619871432","author":"U Pollak","year":"2019","unstructured":"Pollak U, Bronicki RA, Achuff BJ, Checchia PA (2019) Postoperative pain management in pediatric patients undergoing cardiac surgery: where are we heading? J Intensiv Care Med. https:\/\/doi.org\/10.1177\/0885066619871432","journal-title":"J Intensiv Care Med"},{"issue":"4","key":"2598_CR11","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/17425255.2018.1461836","volume":"14","author":"GA Zeilmaker","year":"2018","unstructured":"Zeilmaker GA, Pokorna P, Mian P, Wildschut ED, Knibbe CA, Krekels EH, Allegaert K, Tibboel D (2018) Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients. Expert Opin Drug Metab Toxicol 14(4):417\u2013428","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"4","key":"2598_CR12","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/1053-0770(93)90158-H","volume":"7","author":"O Dagan","year":"1993","unstructured":"Dagan O, Klein J, Bohn D, Barker G, Koren G (1993) Morphine pharmacokinetics in children following cardiac surgery: effects of disease and inotropic support. J Cardiothorac Vasc Anesth 7(4):396\u2013398","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"5","key":"2598_CR13","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1152\/japplphysiol.00619.2001","volume":"92","author":"KA Waters","year":"2002","unstructured":"Waters KA, McBrien F, Stewart P, Hinder M, Wharton S (2002) Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children. J Appl Physiol 92(5):1987\u20131994","journal-title":"J Appl Physiol"},{"issue":"4","key":"2598_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/00000542-200404000-00009","volume":"100","author":"KA Brown","year":"2004","unstructured":"Brown KA, Laferri\u00e8re A, Moss IR (2004) Recurrent hypoxemia in young children with obstructive sleep apnea is associated with reduced opioid requirement for analgesia. J Am Soc Anesthesiol 100(4):806\u2013810","journal-title":"J Am Soc Anesthesiol"},{"issue":"4","key":"2598_CR15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/00000542-200610000-00009","volume":"105","author":"KA Brown","year":"2006","unstructured":"Brown KA, Laferriere A, Lakheeram I, Moss IR (2006) Recurrent hypoxemia in children is associated with increased analgesic sensitivity to opiates. J Am Soc Anesthesiol 105(4):665\u2013669","journal-title":"J Am Soc Anesthesiol"},{"issue":"4","key":"2598_CR16","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/00000542-200610000-00017","volume":"105","author":"IR Moss","year":"2006","unstructured":"Moss IR, Brown KA, Laferri\u00e8re A (2006) Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl. J Am Soc Anesthesiol 105(4):715\u2013718","journal-title":"J Am Soc Anesthesiol"},{"issue":"12","key":"2598_CR17","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1111\/j.1460-9592.2010.03453.x","volume":"20","author":"JA Rabbitts","year":"2010","unstructured":"Rabbitts JA, Groenewald CB, Dietz NM, Morales C, Raesaenen J (2010) Perioperative opioid requirements are decreased in hypoxic children living at altitude. Pediatr Anesth 20(12):1078\u20131083","journal-title":"Pediatr Anesth"},{"issue":"5","key":"2598_CR18","doi-asserted-by":"publisher","first-page":"e0127809","DOI":"10.1371\/journal.pone.0127809","volume":"10","author":"A Turan","year":"2015","unstructured":"Turan A, You J, Egan C, Fu A, Khanna A, Eshraghi Y, Ghosh R, Bose S, Qavi S, Arora L (2015) Chronic intermittent hypoxia is independently associated with reduced postoperative opioid consumption in bariatric patients suffering from sleep-disordered breathing. PLoS ONE 10(5):e0127809","journal-title":"PLoS ONE"},{"issue":"4","key":"2598_CR19","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1097\/ALN.0b013e31819c480a","volume":"110","author":"KA Brown","year":"2009","unstructured":"Brown KA (2009) Intermittent hypoxia and the practice of anesthesia. J Am Soc Anesthesiol 110(4):922\u2013927","journal-title":"J Am Soc Anesthesiol"},{"issue":"4","key":"2598_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0361-9230(02)00915-2","volume":"59","author":"A Laferri\u00e8re","year":"2003","unstructured":"Laferri\u00e8re A, Liu J-K, Moss IR (2003) Neurokinin-1 versus mu-opioid receptor binding in rat nucleus tractus solitarius after single and recurrent intermittent hypoxia. Brain Res Bull 59(4):307\u2013313","journal-title":"Brain Res Bull"},{"issue":"1","key":"2598_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s11325-016-1448-3","volume":"21","author":"J Wu","year":"2017","unstructured":"Wu J, Li P, Wu X (2017) The effect of chronic intermittent hypoxia on respiratory sensitivity to morphine in rats. Sleep Breath 21(1):227\u2013233","journal-title":"Sleep Breath"},{"issue":"4","key":"2598_CR22","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1213\/ANE.0000000000003549","volume":"127","author":"C Cozowicz","year":"2018","unstructured":"Cozowicz C, Chung F, Doufas AG, Nagappa M, Memtsoudis SG (2018) Opioids for acute pain management in patients with obstructive sleep apnea: a systematic review. Anesth Analg 127(4):988\u20131001","journal-title":"Anesth Analg"},{"issue":"1","key":"2598_CR23","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/ACO.0000000000000265","volume":"29","author":"KK Lam","year":"2016","unstructured":"Lam KK, Kunder S, Wong J, Doufas AG, Chung F (2016) Obstructive sleep apnea, pain, and opioids: is the riddle solved? Curr Opin Anaesthesiol 29(1):134\u2013140","journal-title":"Curr Opin Anaesthesiol"},{"issue":"6","key":"2598_CR24","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1097\/ALN.0000000000002664","volume":"130","author":"MC Montana","year":"2019","unstructured":"Montana MC, Juriga L, Sharma A, Kharasch ED (2019) Opioid sensitivity in children with and without obstructive sleep apnea. Anesthesiology 130(6):936\u2013945","journal-title":"Anesthesiology"},{"issue":"4","key":"2598_CR25","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1213\/ANE.0b013e3181cfc435","volume":"110","author":"S Raghavendran","year":"2010","unstructured":"Raghavendran S, Bagry H, Detheux G, Zhang X, Brouillette RT, Brown KA (2010) An anesthetic management protocol to decrease respiratory complications after adenotonsillectomy in children with severe sleep apnea. Anesth Analg 110(4):1093\u20131101","journal-title":"Anesth Analg"},{"issue":"5","key":"2598_CR26","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1542\/peds.2011-2607","volume":"129","author":"S Sadhasivam","year":"2012","unstructured":"Sadhasivam S, Chidambaran V, Ngamprasertwong P, Esslinger HR, Prows C, Zhang X, Martin LJ, McAuliffe J (2012) Race and unequal burden of perioperative pain and opioid related adverse effects in children. Pediatrics 129(5):832\u2013838","journal-title":"Pediatrics"},{"issue":"12","key":"2598_CR27","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1097\/AJP.0b013e318287a258","volume":"29","author":"A Turan","year":"2013","unstructured":"Turan A, Atim A, Dalton JE, Keeyapaj W, Chu W, Bernstein E, Fu A, Ho LJ, Saager L, Sessler DI (2013) Preoperative angiotensin-converting enzyme inhibitor use is not associated with increased postoperative pain and opioid use. Clin J Pain 29(12):1050\u20131056","journal-title":"Clin J Pain"},{"issue":"2","key":"2598_CR28","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/ALN.0000000000000262","volume":"121","author":"E Farag","year":"2014","unstructured":"Farag E, Atim A, Ghosh R, Bauer M, Sreenivasalu T, Kot M, Kurz A, Dalton JE, Mascha EJ, Mounir-Soliman L (2014) Comparison of three techniques for ultrasound-guided femoral nerve catheter insertion: a randomized, blinded trial. J Am Soc Anesthesiol 121(2):239\u2013248","journal-title":"J Am Soc Anesthesiol"},{"issue":"3","key":"2598_CR29","first-page":"293","volume":"23","author":"SI Merkel","year":"1997","unstructured":"Merkel SI, Voepel-Lewis T, Shayevitz JR, Malviya S (1997) The FLACC: a behavioral scale for scoring postoperative pain in young children. Pediatr Nurs 23(3):293\u2013297","journal-title":"Pediatr Nurs"},{"issue":"7","key":"2598_CR30","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1007\/s00246-012-0233-8","volume":"33","author":"AN Naguib","year":"2012","unstructured":"Naguib AN, Dewhirst E, Winch PD, Simsic J, Galantowicz M, Tobias JD (2012) Pain management after surgery for single-ventricle palliation using the hybrid approach. Pediatr Cardiol 33(7):1104\u20131108","journal-title":"Pediatr Cardiol"},{"issue":"1","key":"2598_CR31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s00246-012-0381-x","volume":"34","author":"AN Naguib","year":"2013","unstructured":"Naguib AN, Dewhirst E, Winch PD, Simsic J, Galantowicz M, Tobias JD (2013) Pain management after comprehensive stage 2 repair for hypoplastic left heart syndrome. Pediatr Cardiol 34(1):52\u201358","journal-title":"Pediatr Cardiol"},{"issue":"1","key":"2598_CR32","doi-asserted-by":"publisher","first-page":"e54807","DOI":"10.1371\/journal.pone.0054807","volume":"8","author":"AG Doufas","year":"2013","unstructured":"Doufas AG, Tian L, Padrez KA, Suwanprathes P, Cardell JA, Maecker HT, Panousis P (2013) Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea. PLoS ONE 8(1):e54807","journal-title":"PLoS ONE"},{"issue":"1","key":"2598_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40140-013-0047-0","volume":"4","author":"AG Doufas","year":"2014","unstructured":"Doufas AG (2014) Obstructive sleep apnea, pain, and opioid analgesia in the postoperative patient. Curr Anesthesiol Rep 4(1):1\u20139","journal-title":"Curr Anesthesiol Rep"},{"issue":"1\u20132","key":"2598_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0034-5687(01)00280-8","volume":"129","author":"T Baker","year":"2001","unstructured":"Baker T, Fuller D, Zabka A, Mitchell G (2001) Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia. Respir Physiol 129(1\u20132):25\u201335","journal-title":"Respir Physiol"},{"issue":"1","key":"2598_CR35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/nyas.12085","volume":"1279","author":"MJ Devinney","year":"2013","unstructured":"Devinney MJ, Huxtable AG, Nichols NL, Mitchell GS (2013) Hypoxia-induced phrenic long-term facilitation: emergent properties. Ann NY Acad Sci 1279(1):143\u2013153","journal-title":"Ann NY Acad Sci"},{"issue":"2\u20133","key":"2598_CR36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0034-5687(00)00130-4","volume":"121","author":"F Powell","year":"2000","unstructured":"Powell F, Huey K, Dwinell M (2000) Central nervous system mechanisms of ventilatory acclimatization to hypoxia. Respir Physiol 121(2\u20133):223\u2013236","journal-title":"Respir Physiol"},{"issue":"2","key":"2598_CR37","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0034-5687(98)00026-7","volume":"112","author":"F Powell","year":"1998","unstructured":"Powell F, Milsom W, Mitchell G (1998) Time domains of the hypoxic ventilatory response. Respir Physiol 112(2):123\u2013134","journal-title":"Respir Physiol"},{"issue":"8","key":"2598_CR38","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1001\/archpedi.159.8.775","volume":"159","author":"C Guilleminault","year":"2005","unstructured":"Guilleminault C, Lee JH, Chan A (2005) Pediatric obstructive sleep apnea syndrome. Arch Pediatr Adolesc Med 159(8):775\u2013785","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"2","key":"2598_CR39","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0165-5876(98)90037-4","volume":"16","author":"OE Brown","year":"1988","unstructured":"Brown OE, Manning SC, Ridenour B (1988) Cor pulmonale secondary to tonsillar and adenoidal hypertrophy: management considerations. Int J Pediatr Otorhinolaryngol 16(2):131\u2013139","journal-title":"Int J Pediatr Otorhinolaryngol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-021-02598-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-021-02598-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-021-02598-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T17:50:16Z","timestamp":1671904216000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-021-02598-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2598"],"URL":"https:\/\/doi.org\/10.1007\/s00246-021-02598-x","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"type":"print","value":"0172-0643"},{"type":"electronic","value":"1432-1971"}],"subject":[],"published":{"date-parts":[[2021,4,19]]},"assertion":[{"value":"26 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. The Human Investigation Committee (IRB) of Nationwide Children\u2019s Hospital approved this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}