{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:55:26Z","timestamp":1782435326016,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00246-021-02619-9","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T07:06:31Z","timestamp":1618988791000},"page":"1356-1364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Outcomes After Fenestration Closure in High-Risk Fontan Candidates"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-7365","authenticated-orcid":false,"given":"Hideto","family":"Ozawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0320-3682","authenticated-orcid":false,"given":"Takaya","family":"Hoashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Ohuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"2619_CR1","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1161\/01.CIR.82.5.1681","volume":"82","author":"ND Bridges","year":"1990","unstructured":"Bridges ND, Lock JE, Castaneda AR (1990) Baffle fenestration with subsequent transcatheter closure. Modification of the Fontan operation for patients at increased risk. Circulation 82:1681\u20131689","journal-title":"Circulation"},{"key":"2619_CR2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/hc0202.102237","volume":"105","author":"MS Lemler","year":"2002","unstructured":"Lemler MS, Scott WA, Leonard SR, Stromberg D, Ramaciotti C (2002) Fenestration improves clinical outcome of the fontan procedure: a prospective, randomized study. Circulation 105:207\u2013212","journal-title":"Circulation"},{"key":"2619_CR3","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1093\/icvts\/ivaa002","volume":"30","author":"A Toncu","year":"2020","unstructured":"Toncu A, Radulescu CR, Dorobantu D, Stoica S (2020) Does routine fenestration improve early and late postoperative outcomes in patients undergoing Fontan palliation? Interact CardioVasc Thorac Surg 30:773\u2013779","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2619_CR4","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/S0003-4975(02)03756-6","volume":"74","author":"R Kaulitz","year":"2002","unstructured":"Kaulitz R, Ziemer G, Paul T, Peuster M, Bertram H, Hausdorf G (2002) Fontan-type procedures: residual lesions and late interventions. Ann Thorac Surg 74:778\u2013785","journal-title":"Ann Thorac Surg"},{"key":"2619_CR5","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1016\/j.jacc.2011.01.031","volume":"57","author":"AM Atz","year":"2011","unstructured":"Atz AM, Travison TG, McCrindle BW et al (2011) Late status of Fontan patients with persistent surgical fenestration. J Am Coll Cardiol 57:2437\u20132443","journal-title":"J Am Coll Cardiol"},{"key":"2619_CR6","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.ejcts.2006.08.025","volume":"30","author":"M Ono","year":"2006","unstructured":"Ono M, Boethig D, Goerler H, Lange M, Westhoff-Bleck M, Breymann T (2006) Clinical outcome of patients 20 years after Fontan operation\u2013effect of fenestration on late morbidity. Eur J Cardiothorac Surg 30:923\u2013929","journal-title":"Eur J Cardiothorac Surg"},{"key":"2619_CR7","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s00246-013-0817-y","volume":"35","author":"RS Loomba","year":"2014","unstructured":"Loomba RS, Danduran ME, Dixon JE, Rao RP (2014) Effect of Fontan fenestration on regional venous oxygen saturation during exercise: further insights into Fontan fenestration closure. Pediatr Cardiol 35:514\u2013520","journal-title":"Pediatr Cardiol"},{"key":"2619_CR8","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jacc.2007.12.063","volume":"52","author":"J Meadows","year":"2008","unstructured":"Meadows J, Lang P, Marx G, Rhodes J (2008) Fontan fenestration closure has no acute effect on exercise capacity but improves ventilatory response to exercise. J Am Coll Cardiol 52:108\u2013113","journal-title":"J Am Coll Cardiol"},{"key":"2619_CR9","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/chd.12451","volume":"2","author":"ME Heal","year":"2017","unstructured":"Heal ME, Jackson LB, Atz AM, Butts RJ (2017) Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables. Congenit Heart Dis 2:399\u2013402","journal-title":"Congenit Heart Dis"},{"key":"2619_CR10","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1161\/01.CIR.102.17.2094","volume":"102","author":"DA Goff","year":"2000","unstructured":"Goff DA, Blume ED, Gauvreau K, Mayer JE, Lock JE, Jenkins KJ (2000) Clinical outcome of fenestrated Fontan patients after closure: the first 10 years. Circulation 102:2094\u20132099","journal-title":"Circulation"},{"key":"2619_CR11","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1510\/icvts.2010.253567","volume":"12","author":"IA Yurlov","year":"2011","unstructured":"Yurlov IA, Podzolkov VP, Zelenikin MM et al (2011) Experience with bidirectional cavopulmonary anastomosis and modified Fontan operation in patients with single ventricle and concomitant visceral heterotaxy. Interact Cardiovasc Thorac Surg 12:563\u2013568","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2619_CR12","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/S0022-5223(03)00117-X","volume":"125","author":"HM Burkhart","year":"2003","unstructured":"Burkhart HM, Dearani JA, Mair DD et al (2003) The modified Fontan procedure: early and late results in 132 adult patients. J Thorac Cardiovasc Surg 125:1252\u20131259","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2619_CR13","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/chd.12468","volume":"12","author":"T Alsaied","year":"2017","unstructured":"Alsaied T, Bokma JP, Engel ME et al (2017) Predicting long-term mortality after Fontan procedures: a risk score based on 6707 patients from 28 studies. Congenit Heart Dis 12:393\u2013398","journal-title":"Congenit Heart Dis"},{"key":"2619_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.ejcts.2006.11.043","volume":"31","author":"RB Hosein","year":"2007","unstructured":"Hosein RB, Clarke AJ, McGuirk SP et al (2007) Factors influencing early and late outcome following the Fontan procedure in the current era. The \u201cTwo Commandments\u201d? Eur J Cardiothorac Surg 31:344\u2013352","journal-title":"Eur J Cardiothorac Surg"},{"key":"2619_CR15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jtcvs.2007.12.032","volume":"136","author":"SJ Kim","year":"2008","unstructured":"Kim SJ, Kim WH, Lim HG, Lee JY (2008) Outcome of 200 patients after an extracardiac Fontan procedure. J Thorac Cardiovasc Surg 136:108\u2013116","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2619_CR16","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.jacc.2011.11.049","volume":"59","author":"Y d'Udekem","year":"2012","unstructured":"d\u2019Udekem Y, Xu MY, Galati JC et al (2012) Predictors of survival after single-ventricle palliation: the impact of right ventricular dominance. J Am Coll Cardiol 59:1178\u20131185","journal-title":"J Am Coll Cardiol"},{"key":"2619_CR17","doi-asserted-by":"publisher","first-page":"e015737","DOI":"10.1161\/JAHA.119.015737","volume":"9","author":"SY Tseng","year":"2020","unstructured":"Tseng SY, Siddiqui S, Di Maria MV et al (2020) Atrioventricular valve regurgitation in single heart disease: a common problem associated with progressive deterioration and mortality. J Am Heart Assoc 9:e015737","journal-title":"J Am Heart Assoc"},{"key":"2619_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1136\/heartjnl-2016-310108","volume":"103","author":"T Alsaied","year":"2017","unstructured":"Alsaied T, Bokma JP, Engel ME et al (2017) Factors associated with long-term mortality after Fontan procedures: a systematic review. Heart 103:104\u2013110","journal-title":"Heart"},{"key":"2619_CR19","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/j.jtcvs.2005.07.050","volume":"130","author":"I Adachi","year":"2005","unstructured":"Adachi I, Yagihara T, Kagisaki K et al (2005) Fontan operation with a viable and growing conduit using pedicled autologous pericardial roll: serial changes in conduit geometry. J Thorac Cardiovasc Surg 130:1517\u20131522","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2619_CR20","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.athoracsur.2007.04.060","volume":"85","author":"R McKay","year":"2008","unstructured":"McKay R, Dearani JA (2008) Extracardiac Fontan with direct cavopulmonary connections. Ann Thorac Surg 85:669\u2013671","journal-title":"Ann Thorac Surg"},{"key":"2619_CR21","doi-asserted-by":"publisher","first-page":"E233","DOI":"10.1002\/ccd.26324","volume":"87","author":"JI Pihkala","year":"2016","unstructured":"Pihkala JI, J\u00e4rvel\u00e4 M, Boldt T et al (2016) Fate of fenestration in children treated with Fontan operation. Catheter Cardiovasc Interv 87:E233\u2013E239","journal-title":"Catheter Cardiovasc Interv"},{"key":"2619_CR22","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/chd.12222","volume":"10","author":"H Ohuchi","year":"2015","unstructured":"Ohuchi H, Negishi J, Noritake K et al (2015) Prognostic value of exercise variables in 335 patients after the Fontan operation: a 23-year single-center experience of cardiopulmonary exercise testing. Congenit Heart Dis 10:105\u2013116","journal-title":"Congenit Heart Dis"},{"key":"2619_CR23","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/S0002-8703(96)90092-7","volume":"131","author":"RL Spicer","year":"1996","unstructured":"Spicer RL, Uzark KC, Moore JW, Mainwaring RD, Lamberti JJ (1996) Aortopulmonary collateral vessels and prolonged pleural effusions after modified Fontan procedures. Am Heart J 131:1164\u20131168","journal-title":"Am Heart J"},{"key":"2619_CR24","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.athoracsur.2008.05.014","volume":"86","author":"J Cai","year":"2008","unstructured":"Cai J, Su Z, Shi Z et al (2008) Nitric oxide and milrinone: combined effect on pulmonary circulation after Fontan-type procedure: a prospective, randomized study. Ann Thorac Surg 86:882\u2013888","journal-title":"Ann Thorac Surg"},{"key":"2619_CR25","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1093\/ejcts\/ezz069","volume":"56","author":"G Vigano","year":"2019","unstructured":"Vigano G, McMahon CJ, Walsh K, Oslizlok P, Franklin O, Nolke L et al (2019) High-risk Fontan completion patients achieve low perioperative risk and benefit from cavopulmonary connection 7 years out. Eur J Cardiothorac Surg 56:664\u2013670","journal-title":"Eur J Cardiothorac Surg"},{"key":"2619_CR26","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1016\/j.jtcvs.2014.06.062","volume":"148","author":"Y Kotani","year":"2014","unstructured":"Kotani Y, Chetan D, Saedi A et al (2014) Persistent fenestration may be a marker for physiologic intolerance after Fontan completion. J Thorac Cardiovasc Surg 148:2532\u20132538","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-021-02619-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-021-02619-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-021-02619-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T03:41:00Z","timestamp":1626838860000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-021-02619-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["2619"],"URL":"https:\/\/doi.org\/10.1007\/s00246-021-02619-9","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"9 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors declared that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}