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The aim of this study was to assess the frequency of coronary artery anomalies (CAAs) especially those associated with major coronary branches crossing the right ventricular outflow tract (RVOT) and to describe their relevance for the feasibility of percutaneous pulmonary valve implantation (PPVI). In our retrospective single-center study 90 patients were evaluated who underwent invasive testing for PPVI in our institution from 1\/2010 to 1\/2020. CAAs were identified in seven patients (8%) associated with major branches crossing the RVOT due to origin of the left anterior descending (LAD) or a single coronary artery from the right aortic sinus. In 5\/7 patients with CAAs balloon testing of the RVOT and selective coronary angiographies revealed a sufficiently large landing zone distal to the coronary artery branch. While unfavorable RVOT dimensions prevented PPVI in one, PPVI was performed successfully in the remaining four patients. The relatively short landing zone required application of the \u201cfolded\u201d melody technique in two patients. All patients are doing well (mean follow-up 3\u00a0years). CAAs associated with major coronary branches crossing the RVOT can be expected in about 8% of patients who are potential candidates for PPVI. Since the LAD crossed the RVOT below the plane of the pulmonary valve successful distal implantation of the valve was possible in 4\/7 patients. Therefore these coronary anomalies should not be considered as primary contraindications for PPVI.<\/jats:p>","DOI":"10.1007\/s00246-021-02684-0","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T07:03:58Z","timestamp":1628319838000},"page":"8-16","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Coronary Artery Anomalies and Their Impact on the Feasibility of Percutaneous Pulmonary Valve Implantation"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-8444","authenticated-orcid":false,"given":"Anja","family":"Hanser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hornung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludger","family":"Sieverding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-1132","authenticated-orcid":false,"given":"Michael","family":"Hofbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"2684_CR1","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1016\/j.jcin.2017.05.022","volume":"10","author":"AK Cabalka","year":"2017","unstructured":"Cabalka AK, Hellenbrand WE, Eicken A, Kreutzer J, Gray RG, Bergersen L, Berger F, Armstrong AK, Cheatham JP, Zahn EM, McElhinney DB (2017) Relationships among conduit type, pre-stenting, and outcomes in patients undergoing transcatheter pulmonary valve replacement in the prospective North American and European melody valve trials. 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Hanser and A. Hornung have received research grants from the \u201cStiftung zur F\u00f6rderung der Erforschung der Zivilisationerkrankungen.\u201d A. Hanser reports grants from the Deutsche Herzstiftung e.V. The other authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective study was approved by the Ethics Committee at the Medical Faculty of the Eberhard Karls University and at the University Hospital Tuebingen (project number 307\/2020BO2).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Written consent was not required, as this is a retrospective data analysis. Date of registration 15\/05\/2020.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The present paper is not under consideration elsewhere and has not been published elsewhere. All authors have read and approved the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}