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The aim of the study was to determine predictors of LVOTO and to evaluate the relationship between aortic valve (AoV) morphology and the re-intervention rate. Retrospective review of patients, who underwent a conventional repair for IAA\/CoA with VSD at a tertiary referral center between 1996 and 2017. The preoperative demographic data as well as pre- and post-operative echocardiographic parameters and re-interventions were reviewed. In the median follow-up of 8.3\u00a0years (range of 6.15\u201310.27) 5 patients (11.9%) from a total of 47 patients included in the study presented with a significant LVOTO. Four of them required reoperation after median period of 2.3\u00a0years (range of 0.3\u20137.9) after the initial surgery. Multivariable logistic regression identified AoV z-score (OR 0.44, <jats:italic>p<\/jats:italic>\u2009=\u20090.017) as predictor of LVOTO. The mean AoV z-score before the primary repair was significantly smaller in those with LVOTO as compared to those with unobstructed flow from the LV (\u2212\u20093.58\u2009\u00b1\u20091.96 vs.\u2009\u2212\u20091.44\u2009\u00b1\u20091.55; <jats:italic>p<\/jats:italic>\u2009=\u20090.0016). At 1-year follow-up, both groups showed an increase in the AoV z-score (<jats:italic>p<\/jats:italic>\u2009=\u20090.98). The re-intervention rate after primary repair (both surgical procedures and percutaneous interventions), either for LVOTO or reCoA, was higher in patients with AoV z-score\u2009\u2264\u2009\u2009\u2212\u20093 (<jats:italic>p<\/jats:italic>\u2009=\u20090.007 vs. <jats:italic>p<\/jats:italic>\u2009=\u20090.46) and those, whose aortic annulus was less or equal than patient\u2019s weight (kg)\u2009+\u20091.5\u00a0mm as compared to those with larger aortic annulus (<jats:italic>p<\/jats:italic>\u2009=\u20090.03 vs. <jats:italic>p<\/jats:italic>\u2009=\u20090.16). In patients after surgical treatment of IAA\/CoA with VSD, the AoV z-score at diagnosis is a significant risk factor for reoperation for LVOTO. With age, AoV growth and z-score improvement is expected. Small AoV at diagnosis is correlated with increased rate of re-intervention for LVOTO and reCoA.<\/jats:p>","DOI":"10.1007\/s00246-021-02749-0","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T16:03:20Z","timestamp":1635264200000},"page":"525-531","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Predictors of Left Ventricular Outflow Tract Obstruction After Conventional Repair for Patients with Interrupted Aortic Arch or Coarctation of the Aorta, Combined with Ventricular Septal Defect: A Single-Center Experience"],"prefix":"10.1007","volume":"43","author":[{"given":"Katarzyna","family":"Szaflik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Goreczny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Ostrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kazmierczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga A.","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"issue":"3","key":"2749_CR1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/S1010-7940(97)00194-2","volume":"12","author":"C Schreiber","year":"1997","unstructured":"Schreiber C, Mazzitelli D, Haehnel JC, Lorenz HP, Meisner H (1997) The interrupted aortic arch: an overview after 20 years of surgical treatment. 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Approval was granted by the Ethics Committee of Polish Mother\u2019s Memorial Hospital, Research Institute, Lodz, Poland (12.01.2016\/No. 25).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Written informed consent was obtained from the parents.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"Parents signed informed consent regarding publishing their children\u2019s data and photographs.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}