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We evaluated the efficacy of short-term oral prednisolone administration, which is the initial treatment for postoperative pericardial effusion without cardiac tamponade at our institution. Between October 2008 and March 2020, 1429 pediatric cardiac surgeries were performed at our institution. 91 patients required postoperative treatment for pericardial effusion. 81 were treated with short-term oral prednisolone. Pericardial effusion was evaluated using serial echocardiography during diastole. Pericardial drainage was performed for patients with circumferential pericardial effusion with a maximum diameter of\u2009\u2265\u200910\u00a0mm or signs of cardiac tamponade. Short-term oral prednisolone treatment was administered to patients with circumferential pericardial effusion with a maximum diameter of\u2009&lt;\u200910\u00a0mm or localized pericardial effusion with a maximum diameter of\u2009\u2265\u20095\u00a0mm. Patients with localized pericardial effusion with a maximum diameter of\u2009&lt;\u20095\u00a0mm were observed. Prednisolone (2\u00a0mg\/kg\/day) was administered orally for 3\u00a0days, added as needed. Short-term oral prednisolone treatment was effective in 71 cases and 90% of patients were regarded as responders. The remaining patients were deemed non-responders who required pericardial drainage. Overall, 55 responders were deemed early responders whose pericardial effusion disappeared within 3\u00a0days. There were no cases of deaths, infections, or recurrence of pericardial effusion. The amount of drainage fluid on the day of surgery was higher in the non-responders. In conclusion, short-term oral prednisolone treatment is effective and safe for treating pericardial effusion without cardiac tamponade after pediatric cardiac surgery.<\/jats:p>","DOI":"10.1007\/s00246-021-02783-y","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T21:29:01Z","timestamp":1638394141000},"page":"764-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Short-Term Oral Prednisolone Treatment in the Management of Pericardial Effusion Following Pediatric Cardiac Surgery"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-2869","authenticated-orcid":false,"given":"Masahiro","family":"Mizumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-6495","authenticated-orcid":false,"given":"Naoki","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-2676","authenticated-orcid":false,"given":"Sadahiro","family":"Sai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"2783_CR1","doi-asserted-by":"publisher","first-page":"e107","DOI":"10.1016\/j.ejcts.2010.12.021","volume":"39","author":"G Pompilio","year":"2011","unstructured":"Pompilio G, Filippini S, Agrifoglio M et al (2011) Determinants of pericardal drainage for cardiac tamponade following cardiac surgery. 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