{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:39:56Z","timestamp":1789839596315,"version":"4.0.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00246-022-02870-8","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T08:02:42Z","timestamp":1647331362000},"page":"1471-1480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Secrets of the Frogs Heart"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-0992","authenticated-orcid":false,"given":"Antonio F.","family":"Corno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh C.","family":"Uppu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Milewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge D.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"2870_CR1","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/S0003-4975(10)60917-4","volume":"34","author":"AF Corno","year":"1982","unstructured":"Corno AF, Becker AE, Bulterijs AHK et al (1982) Univentricular heart: can we alter the natural history? Ann Thorac Surg 34:716\u2013726","journal-title":"Ann Thorac Surg"},{"key":"2870_CR2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0022-5223(19)35562-X","volume":"100","author":"C Marcelletti","year":"1990","unstructured":"Marcelletti C, Corno AF, Giannico S, Marino B (1990) Inferior vena cava to pulmonary artery extracardiac conduit: a new form of right heart bypass. J Thorac Cardiovasc Surg 100:228\u2013232","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2870_CR3","first-page":"110","volume":"86","author":"S Giannico","year":"1992","unstructured":"Giannico S, Corno AF, Marino B et al (1992) Total extracardiac right heart bypass. Circulation 86:110\u2013117","journal-title":"Circulation"},{"key":"2870_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1017\/S1047951101000051","volume":"11","author":"R Buchhorn","year":"2001","unstructured":"Buchhorn R, Bartmus D, Buhre W, Bursch J (2001) Pathogenetic mechanisms of venous congestion after the Fontan procedure. Cardiol Young 11:161\u2013168","journal-title":"Cardiol Young"},{"key":"2870_CR5","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1016\/S0003-4975(03)00450-8","volume":"76","author":"BW Duncan","year":"2003","unstructured":"Duncan BW, Desai S (2003) Pulmonary arteriovenous malformations after cavopulmonary anastomosis. Ann Thorac Surg 76:1759\u20131766","journal-title":"Ann Thorac Surg"},{"key":"2870_CR6","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/00005176-200303000-00009","volume":"36","author":"MR Narkewicz","year":"2003","unstructured":"Narkewicz MR, Sondheimer HM, Ziegler JW (2003) Hepatic dysfunction following the Fontan operation. J Pediatr Gastroenterol Nutr 36:352\u2013357","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2870_CR7","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/nrcardio.2010.99","volume":"7","author":"MR de Leval","year":"2010","unstructured":"de Leval MR, Deanfield JE (2010) Four decades of Fontan palliation. Nat Rev Cardiol 7:520\u2013527","journal-title":"Nat Rev Cardiol"},{"key":"2870_CR8","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1136\/heartjnl-2015-307467","volume":"102","author":"M Gewillig","year":"2016","unstructured":"Gewillig M, Brown SC (2016) The Fontan circulation after 45 years: update in physiology. Heart 102:1081\u20131086","journal-title":"Heart"},{"key":"2870_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/chd.12401","volume":"12","author":"KN Pundi","year":"2017","unstructured":"Pundi KN, Pundi KN, Johnson JN et al (2017) Sudden cardiac death and late arrhythmias after the Fontan operation. Congenit Heart Dis 12:17\u201323","journal-title":"Congenit Heart Dis"},{"key":"2870_CR10","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.jacc.2017.12.054","volume":"71","author":"M Dennis","year":"2018","unstructured":"Dennis M, Zannino D, du Plessis K et al (2018) Clinical outcomes in adolescents and adults after the Fontan procedure. J Am Coll Cardiol 71:1009\u20131017","journal-title":"J Am Coll Cardiol"},{"key":"2870_CR11","doi-asserted-by":"publisher","first-page":"e012008","DOI":"10.1161\/JAHA.119.012008","volume":"8","author":"G Claessen","year":"2019","unstructured":"Claessen G, La Gerche A, Van De Bruaene A et al (2019) Heart rate reserve in Fontan patients: chronotropic incompetence or hemodynamic limitation? J Am Heart Assoc 8:e012008. https:\/\/doi.org\/10.1161\/JAHA.119.012008","journal-title":"J Am Heart Assoc"},{"key":"2870_CR12","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1023\/B:CAIM.0000021881.57609.b4","volume":"20","author":"G Restaino","year":"2004","unstructured":"Restaino G, Dirksen MS, de Roos A (2004) Long-term survival in a case of unoperated single ventricle. Int J Cardiovasc Imaging 20:221\u2013225","journal-title":"Int J Cardiovasc Imaging"},{"key":"2870_CR13","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0002-9149(97)89356-3","volume":"77","author":"NM Ammash","year":"1996","unstructured":"Ammash NM, Warnes CA (1996) Survival into adulthood of patients with unoperated single ventricle. Am J Cardiol 77:542\u2013544","journal-title":"Am J Cardiol"},{"key":"2870_CR14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1136\/heartjnl-2015-308440","volume":"102","author":"JT Poterucha","year":"2016","unstructured":"Poterucha JT, Anavekar NS, Egbe AC et al (2016) Survival and outcomes of patients with unoperated single ventricle. Heart 102:216\u2013222","journal-title":"Heart"},{"key":"2870_CR15","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1510\/icvts.2009.223024","volume":"10","author":"AF Corno","year":"2010","unstructured":"Corno AF, Vergara C, Subramanian C et al (2010) Assisted Fontan procedure: animal and in vitro models and computational fluid dynamics study. Interactive CardioVasc Thorac Surg 10:679\u2013684","journal-title":"Interactive CardioVasc Thorac Surg"},{"key":"2870_CR16","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.compbiomed.2017.08.024","volume":"89","author":"C Puelz","year":"2017","unstructured":"Puelz C, Acosta S, Riviere B, Penny DJ, Brady KM, Rusin CG (2017) A computational study of the Fontan circulation with fenestration or hepatic vein exclusion. Comput Biol Med 89:405\u2013418","journal-title":"Comput Biol Med"},{"key":"2870_CR17","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1161\/CIRCULATIONAHA.117.033359","volume":"137","author":"FM Rijnberg","year":"2018","unstructured":"Rijnberg FM, Hazekamp MG, Wentzel JJ et al (2018) Energetics of blood flow in cardiovascular disease concept and clinical implications of adverse energetics in patients with a Fontan circulation. Circulation 137:2393\u20132407","journal-title":"Circulation"},{"key":"2870_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1053\/j.pcsu.2020.01.001","volume":"23","author":"TY Hsia","year":"2020","unstructured":"Hsia TY, Conover T, Figliola R, for the Modeling of Congenital Hearts Alliance (MOCHA) Investigators (2020) Computational modeling to support surgical decision making in single ventricle physiology. Semin Thorac Cardiovasc Surg Pediatr Card Surg Ann 23:2\u201310","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Ann"},{"key":"2870_CR19","first-page":"241","volume":"17","author":"JW Hicks","year":"2002","unstructured":"Hicks JW (2002) The physiological and evolutionary significance of cardiovascular shunting patterns in reptiles. News Physiol Sci 17:241\u2013245","journal-title":"News Physiol Sci"},{"key":"2870_CR20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1152\/physrev.1994.74.1.221","volume":"74","author":"WR Driedzic","year":"1994","unstructured":"Driedzic WR, Gesser H (1994) Energy metabolism and contractility in ectothermic vertebrate hearts: hypoxia, acidosis and low temperature. Physiol Rev 74:221\u2013258","journal-title":"Physiol Rev"},{"key":"2870_CR21","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/ilar.48.3.260","volume":"48","author":"WW Burggren","year":"2007","unstructured":"Burggren WW, Warburton S (2007) Amphibians as animal models for laboratory research in physiology. ILAR J 48:260\u2013269","journal-title":"ILAR J"},{"key":"2870_CR22","doi-asserted-by":"publisher","unstructured":"O\u2019Rourke DP, Rosenbaum MD (2015). Biology and diseases of amphibians. In: Laboratory animal medicine, third edn. Elsevier Inc, Amsterdam, pp 931\u2013965. https:\/\/doi.org\/10.1016\/B978-0-12-409527-4.00018-3","DOI":"10.1016\/B978-0-12-409527-4.00018-3"},{"key":"2870_CR23","unstructured":"Pokhrel P (2016). Respiratory system in frogs.\u00a0BiologyOctober 14. https:\/\/microbiologynotes.com\/respiratory-system-frog\/"},{"key":"2870_CR24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/01.CIR.23.1.91","volume":"23","author":"WN Chambers","year":"1961","unstructured":"Chambers WN, Criscittiello MG, Goodale F (1961) Cor triloculare biatriatum. Survival to adult life. Circulation 23:91\u2013101","journal-title":"Circulation"},{"key":"2870_CR25","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/jmor.1051090307","volume":"109","author":"HL Sharma","year":"1961","unstructured":"Sharma HL (1961) The circulatory mechanism and anatomy of the heart of the frog, Rana pipiens. J Morphol 109:323\u2013349","journal-title":"J Morphol"},{"key":"2870_CR26","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1749-6632.1965.tb49419.x","volume":"127","author":"FJ Haberich","year":"1965","unstructured":"Haberich FJ (1965) The functional separation of venous and arterial blood in the univentricular frog heart. Ann N Y Acad Sci 127:459\u2013476","journal-title":"Ann N Y Acad Sci"},{"key":"2870_CR27","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1242\/jeb.105536","volume":"217","author":"SS Hillman","year":"2014","unstructured":"Hillman SS, Hedrick MS, Kohl ZF (2014) Net cardiac shunts in anuran amphibians: physiology or physics? J Exp Biol 217:2844\u20132847","journal-title":"J Exp Biol"},{"key":"2870_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188048","author":"SL Meyer","year":"2017","unstructured":"Meyer SL, Jongbloed MR, Ho SY et al (2017) Intracardiac anatomical relationships and potential for streaming in double inlet left ventricles. PLosOne. https:\/\/doi.org\/10.1371\/journal.pone.0188048","journal-title":"PLosOne"},{"key":"2870_CR29","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1748-1716.1980.tb06550.x","volume":"108","author":"G Lagerstrand","year":"1980","unstructured":"Lagerstrand G, Poupa O (1980) Effects of calcium and pH on the mechanical performance of heart muscle in the frog, Rana temporaria, during anoxia and subsequent recovery. Acta Physiol Scand 108:399\u2013404","journal-title":"Acta Physiol Scand"},{"key":"2870_CR30","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/BF00716025","volume":"1","author":"R Ventura-Clapier","year":"1980","unstructured":"Ventura-Clapier R, Vassort G (1980) Electrical and mechanical activities of frog heart during energetic deficiency. J Muscle Res Cell Motil 1:429\u2013444","journal-title":"J Muscle Res Cell Motil"},{"key":"2870_CR31","first-page":"S9","volume":"256","author":"VA Knight","year":"1989","unstructured":"Knight VA, Richardson DR, Makoba B (1989) Use of frog ventricle to examine mechanical and electrical activity of heart. Am J Physiol 256:S9-13","journal-title":"Am J Physiol"},{"key":"2870_CR32","first-page":"107","volume":"60","author":"HL Bartlett","year":"2010","unstructured":"Bartlett HL, Escalera RB, Patel SS et al (2010) Echocardiographic assessment of cardiac morphology and function in Xenopus. Comp Med 60:107\u2013113","journal-title":"Comp Med"},{"key":"2870_CR33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1161\/01.CIR.56.2.139","volume":"56","author":"R Van Praagh","year":"1977","unstructured":"Van Praagh R (1977) Terminology of congenital heart disease: glossary and commentary. Circulation 56:139\u2013143","journal-title":"Circulation"},{"key":"2870_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044231","volume":"7","author":"B Jensen","year":"2012","unstructured":"Jensen B, Boukens JD, Postma AV et al (2012) Identifying the evolutionary building block of the cardiac conduction system. PlosOne 7:e44231. https:\/\/doi.org\/10.1371\/journal.pone.0044231","journal-title":"PlosOne"},{"key":"2870_CR35","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1242\/dev.124.8.1465","volume":"124","author":"JL Lohr","year":"1977","unstructured":"Lohr JL, Danos MC, Yost HJ (1977) Left-right asymmetry and a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development. Development 124:1465\u20131472","journal-title":"Development"},{"key":"2870_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/(SICI)1520-6408(1998)23:3<185::AID-DVG4>3.0.CO;2-1","volume":"23","author":"M Levin","year":"1998","unstructured":"Levin M, Mercola M (1998) Evolutionary conservation of mechanisms upstream of asymmetric Nodal expression: reconciling chick and Xenopus. Develop Genet 23:185\u2013193","journal-title":"Develop Genet"},{"key":"2870_CR37","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/(SICI)1520-6408(1998)23:3<194::AID-DVG5>3.0.CO;2-0","volume":"23","author":"JL Lohr","year":"1998","unstructured":"Lohr JL, Danos MC, Groth TV, Yost HJ (1998) Maintenance of asymmetric Nodal expression in Xenopus laevis. Develop Genet 23:194\u2013202","journal-title":"Develop Genet"},{"key":"2870_CR38","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1161\/01.RES.0000202800.85341.6e","volume":"94","author":"F Bajolle","year":"2006","unstructured":"Bajolle F, Zaffran S, Kelly RG et al (2006) Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries. Circ Res 94:421\u2013428","journal-title":"Circ Res"},{"key":"2870_CR39","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/nature07603","volume":"457","author":"C Grande","year":"2008","unstructured":"Grande C, Patel NH (2008) Nodal signalling is involved in left-right asymmetry in snails. Nature 457:1007\u20131011","journal-title":"Nature"},{"key":"2870_CR40","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1002\/ajmg.a.33655","volume":"152","author":"M Oliverio","year":"2010","unstructured":"Oliverio M, Digiglio MC, Versacci P, Dallapiccola B, Marino B (2010) Shells and heart: are human laterality and chirality of snails controlled by the same maternal genes? Am J Med Genet 152:2419\u20132425","journal-title":"Am J Med Genet"},{"key":"2870_CR41","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.ahj.2010.12.023","volume":"161","author":"P Versacci","year":"2011","unstructured":"Versacci P, Digiglio MC, Oliverio M, Dallapiccola B, Marino B (2011) The heart and shell. Anatomical and genetic similarities. Am Heart J 161:647\u2013649","journal-title":"Am Heart J"},{"key":"2870_CR42","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ajmg.10376","volume":"110","author":"B Marino","year":"2002","unstructured":"Marino B, Digilio MC, Di Donato R (2002) Transposition of the great arteries in asplenia and polysplenia phenotypes. Am J Med Genet 110:292\u2013294","journal-title":"Am J Med Genet"},{"key":"2870_CR43","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/S0022-5223(03)00797-9","volume":"126","author":"B Marino","year":"2003","unstructured":"Marino B, Corno AF (2003) Spiral pattern: universe, normal heart, and complex congenital heart defects. J Thorac Cardiovasc Surg 126:1225\u20131226","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2870_CR44","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1136\/hrt.2009.181685","volume":"96","author":"A DeLuca","year":"2020","unstructured":"DeLuca A, Sarkozy A, Consoli F et al (2020) familial transposition of the great arteries caused by multiple mutations in laterality genes. Heart 96:673\u2013677","journal-title":"Heart"},{"key":"2870_CR45","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1006\/dbio.2000.9753","volume":"223","author":"VM Christoffels","year":"2000","unstructured":"Christoffels VM, Habets PEMH, Franco D et al (2000) Chamber formation and morphogenesis in the developing mammalian heart. Develop Biol 223:266\u2013278","journal-title":"Develop Biol"},{"key":"2870_CR46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1161\/01.RES.0000027135.63141.89","volume":"91","author":"VH Lamers","year":"2002","unstructured":"Lamers VH, Moorman AFM (2002) Cardiac septation: a late contricution of the embryonic primary myocardium to heart morphogenesis. Circ Res 91:93\u2013103","journal-title":"Circ Res"},{"key":"2870_CR47","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1152\/physrev.00006.2003","volume":"83","author":"AFM Moorman","year":"2003","unstructured":"Moorman AFM, Christoffels VM (2003) Cardiac chamber formation: development, genes and evolution. Physiol Rev 83:1223\u20131267","journal-title":"Physiol Rev"},{"key":"2870_CR48","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1002\/ajmg.a.35896","volume":"164A","author":"M Sylva","year":"2014","unstructured":"Sylva M, van den Hoff MJB, Moorman AFM (2014) Development of the human heart. Am J Med Genet 164A:1347\u20131371","journal-title":"Am J Med Genet"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-022-02870-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-022-02870-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-022-02870-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T08:26:31Z","timestamp":1726820791000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-022-02870-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["2870"],"URL":"https:\/\/doi.org\/10.1007\/s00246-022-02870-8","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,15]]},"assertion":[{"value":"11 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Authors have no disclosure of any conflict of interest, financial and non-financial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}