{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:28:50Z","timestamp":1747153730034,"version":"3.40.5"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s00246-022-02945-6","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T14:10:50Z","timestamp":1655215850000},"page":"727-731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reversal of Fetal Heart Block in Antibody-Positive Mother After Hydroxychloroquine and Dexamethasone"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8721-5930","authenticated-orcid":false,"given":"Mehar","family":"Hoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Duryea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Ikemba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"issue":"1","key":"2945_CR1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/s0735-1097(01)01697-7","volume":"39","author":"ET Jaeggi","year":"2002","unstructured":"Jaeggi ET, Hamilton RM, Silverman ED, Zamora SA, Hornberger LK (2002) Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block: a single institution\u2019s experience of 30 years. J Am Coll Cardiol 39(1):130\u2013137. https:\/\/doi.org\/10.1016\/s0735-1097(01)01697-7","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2945_CR2","doi-asserted-by":"publisher","first-page":"e023000","DOI":"10.1161\/JAHA.121.023000","volume":"11","author":"W Mawad","year":"2022","unstructured":"Mawad W, Hornberger L, Cuneo B, Raboisson MJ, Moon-Grady AJ, Lougheed J et al (2022) Outcome of antibody-mediated fetal heart disease with standardized anti-inflammatory transplacental treatment. J Am Heart Assoc 11(3):e023000. https:\/\/doi.org\/10.1161\/JAHA.121.023000","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"2945_CR3","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1161\/CIRCULATIONAHA.107.735118","volume":"118","author":"LM Lopes","year":"2008","unstructured":"Lopes LM, Tavares GM, Damiano AP, Lopes MA, Aiello VD, Schultz R et al (2008) Perinatal outcome of fetal atrioventricular block: one-hundred-sixteen cases from a single institution. Circulation 118(12):1268\u20131275. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.735118","journal-title":"Circulation"},{"issue":"18","key":"2945_CR4","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1161\/CIRCULATIONAHA.111.041970","volume":"124","author":"H Eliasson","year":"2011","unstructured":"Eliasson H, Sonesson SE, Sharland G, Granath F, Simpson JM, Carvalho JS et al (2011) Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patients. Circulation 124(18):1919\u20131926. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.041970","journal-title":"Circulation"},{"issue":"12","key":"2945_CR5","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.autrev.2015.08.005","volume":"14","author":"K Levesque","year":"2015","unstructured":"Levesque K, Morel N, Maltret A, Baron G, Masseau A, Orquevaux P et al (2015) Description of 214 cases of autoimmune congenital heart block: results of the French neonatal lupus syndrome. Autoimmun Rev 14(12):1154\u20131160. https:\/\/doi.org\/10.1016\/j.autrev.2015.08.005","journal-title":"Autoimmun Rev"},{"key":"2945_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ijcard.2016.09.119","volume":"225","author":"NW Van den Berg","year":"2016","unstructured":"Van den Berg NW, Slieker MG, van Beynum IM, Bilardo CM, de Bruijn D, Clur SA et al (2016) Fluorinated steroids do not improve outcome of isolated atrioventricular block. Int J Cardiol 225:167\u2013171. https:\/\/doi.org\/10.1016\/j.ijcard.2016.09.119","journal-title":"Int J Cardiol"},{"key":"2945_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fcvm.2019.00011","volume":"6","author":"M Fredi","year":"2019","unstructured":"Fredi M, Andreoli L, Bacco B, Bertero T, Bortoluzzi A, Breda S et al (2019) First report of the italian registry on immune-mediated congenital heart block (Lu.Ne Registry). Front Cardiovasc Med. 6:11. https:\/\/doi.org\/10.3389\/fcvm.2019.00011","journal-title":"Front Cardiovasc Med."},{"issue":"1","key":"2945_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12016-009-8190-6","volume":"40","author":"A Brucato","year":"2011","unstructured":"Brucato A, Cimaz R, Caporali R, Ramoni V, Buyon J (2011) Pregnancy outcomes in patients with autoimmune diseases and anti-Ro\/SSA antibodies. Clin Rev Allergy Immunol 40(1):27\u201341. https:\/\/doi.org\/10.1007\/s12016-009-8190-6","journal-title":"Clin Rev Allergy Immunol"},{"issue":"7","key":"2945_CR9","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/s0735-1097(98)00161-2","volume":"31","author":"JP Buyon","year":"1998","unstructured":"Buyon JP, Hiebert R, Copel J, Craft J, Friedman D, Katholi M et al (1998) Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol 31(7):1658\u20131666. https:\/\/doi.org\/10.1016\/s0735-1097(98)00161-2","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"2945_CR10","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1161\/CIRCULATIONAHA.111.033894","volume":"124","author":"PM Izmirly","year":"2011","unstructured":"Izmirly PM, Saxena A, Kim MY, Wang D, Sahl SK, Llanos C et al (2011) Maternal and fetal factors associated with mortality and morbidity in a multi-racial\/ethnic registry of anti-SSA\/Ro-associated cardiac neonatal lupus. Circulation 124(18):1927\u20131935. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.033894","journal-title":"Circulation"},{"issue":"5","key":"2945_CR11","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nrrheum.2015.29","volume":"11","author":"P Brito-Zeron","year":"2015","unstructured":"Brito-Zeron P, Izmirly PM, Ramos-Casals M, Buyon JP, Khamashta MA (2015) The clinical spectrum of autoimmune congenital heart block. Nat Rev Rheumatol 11(5):301\u2013312. https:\/\/doi.org\/10.1038\/nrrheum.2015.29","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"2945_CR12","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/s0735-1097(10)80148-2","volume":"17","author":"KG Schmidt","year":"1991","unstructured":"Schmidt KG, Ulmer HE, Silverman NH, Kleinman CS, Copel JA (1991) Perinatal outcome of fetal complete atrioventricular block: a multicenter experience. J Am Coll Cardiol 17(6):1360\u20131366. https:\/\/doi.org\/10.1016\/s0735-1097(10)80148-2","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"2945_CR13","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1080\/14767058.2017.1419182","volume":"32","author":"A Ciardulli","year":"2019","unstructured":"Ciardulli A, D\u2019Antonio F, Magro-Malosso ER, Saccone G, Manzoli L, Radolec M et al (2019) Maternal steroid therapy for fetuses with immune-mediated complete atrioventricular block: a systematic review and meta-analysis. J Maternal-fetal Neonatal Med 32(11):1884\u20131892. https:\/\/doi.org\/10.1080\/14767058.2017.1419182","journal-title":"J Maternal-fetal Neonatal Med"},{"issue":"5","key":"2945_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/rheumatology\/key141","volume":"57","author":"MEB Clowse","year":"2018","unstructured":"Clowse MEB, Eudy AM, Kiernan E, Williams MR, Bermas B, Chakravarty E et al (2018) The prevention, screening and treatment of congenital heart block from neonatal lupus: a survey of provider practices. Rheumatology (Oxford) 57(5):59\u2013517. https:\/\/doi.org\/10.1093\/rheumatology\/key141","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"2945_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/CRD.0000000000000026","volume":"22","author":"A Saxena","year":"2014","unstructured":"Saxena A, Izmirly PM, Mendez B, Buyon JP, Friedman DM (2014) Prevention and treatment in utero of autoimmune-associated congenital heart block. Cardiol Rev 22(6):263\u2013267. https:\/\/doi.org\/10.1097\/CRD.0000000000000026","journal-title":"Cardiol Rev"},{"issue":"8","key":"2945_CR16","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.amjcard.2008.12.027","volume":"103","author":"DM Friedman","year":"2009","unstructured":"Friedman DM, Kim MY, Copel JA, Llanos C, Davis C, Buyon JP (2009) Prospective evaluation of fetuses with autoimmune-associated congenital heart block followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study. Am J Cardiol 103(8):1102\u20131106. https:\/\/doi.org\/10.1016\/j.amjcard.2008.12.027","journal-title":"Am J Cardiol"},{"issue":"8","key":"2945_CR17","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1007\/s10067-019-04556-8","volume":"38","author":"FB Mollerach","year":"2019","unstructured":"Mollerach FB, Scolnik M, Catoggio LJ, Rosa J, Soriano ER (2019) Causes of fetal third-degree atrioventricular block and use of hydroxychloroquine in pregnant women with Ro\/La antibodies. Clin Rheumatol 38(8):2211\u20132217. https:\/\/doi.org\/10.1007\/s10067-019-04556-8","journal-title":"Clin Rheumatol"},{"issue":"10","key":"2945_CR18","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1136\/ard.2009.119263","volume":"69","author":"PM Izmirly","year":"2010","unstructured":"Izmirly PM, Kim MY, Llanos C, Le PU, Guerra MM, Askanase AD et al (2010) Evaluation of the risk of anti-SSA\/Ro-SSB\/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine. Ann Rheum Dis 69(10):1827\u20131830. https:\/\/doi.org\/10.1136\/ard.2009.119263","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2945_CR19","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.111.089268","volume":"126","author":"PM Izmirly","year":"2012","unstructured":"Izmirly PM, Costedoat-Chalumeau N, Pisoni CN, Khamashta MA, Kim MY, Saxena A et al (2012) Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA\/Ro-antibody-associated cardiac manifestations of neonatal lupus. Circulation 126(1):76\u201382. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.089268","journal-title":"Circulation"},{"issue":"3","key":"2945_CR20","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jacc.2020.05.045.PubMedPMID:32674792;PubMedCentralPMCID:PMC7394202","volume":"76","author":"P Izmirly","year":"2020","unstructured":"Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA et al (2020) Hydroxychloroquine to prevent recurrent congenital heart block in fetuses of Anti-SSA\/Ro-positive mothers. J Am Coll Cardiol 76(3):292\u2013302. https:\/\/doi.org\/10.1016\/j.jacc.2020.05.045.PubMedPMID:32674792;PubMedCentralPMCID:PMC7394202","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"2945_CR21","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/GCO.0000000000000528","volume":"31","author":"SC Do","year":"2019","unstructured":"Do SC, Druzin ML (2019) Systemic lupus erythematosus in pregnancy: high risk, high reward. Curr Opin Obstet Gynecol 31(2):120\u2013126","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2945_CR22","first-page":"145","volume":"44","author":"S Tett","year":"1993","unstructured":"Tett S, McLachlan A, Day R, Cutler D (1993) Insights from pharmacokinetic and pharmacodynamic studies of hydroxychloroquine. Agents Actions Suppl 44:145\u2013190","journal-title":"Agents Actions Suppl"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-022-02945-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-022-02945-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-022-02945-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T09:05:10Z","timestamp":1677143110000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-022-02945-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,14]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["2945"],"URL":"https:\/\/doi.org\/10.1007\/s00246-022-02945-6","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"type":"print","value":"0172-0643"},{"type":"electronic","value":"1432-1971"}],"subject":[],"published":{"date-parts":[[2022,6,14]]},"assertion":[{"value":"9 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Parents signed informed consent regarding publishing their data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}}]}}