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The aim of this study is to evaluate the efficacy and safety of transfemoral PMVSD device closure in infants weighing\u2009\u2264\u200910\u00a0kg in a single centre. Retrospective review of departmental databases and medical charts to define patient cohort and collect demographic, procedural and follow-up data. Between July 2014 and March 2021, 16 patients underwent attempted transfemoral PMVSD device closure (12 retrograde) at a median age of 11\u00a0months (interquartile range [IQR] 9\u201315.5) and a median weight of 8.3\u00a0kg (IQR 7.2\u20139.5). All patients were either symptomatic, had progressive left heart dilation or had VSD associated valve regurgitation. Median defect size on pre-procedural transoesophageal echocardiography was 6.8\u00a0mm (IQR 6\u20138.5). Median device waist size was 6\u00a0mm (IQR 4.5\u20138). Successful device placement was achieved in 14 patients (88%). One patient developed moderate aortic and tricuspid valve regurgitation upon retrograde and antegrade device deployment, respectively, and subsequently underwent surgical closure. The second patient developed progressive aortic regurgitation (AR) 2\u00a0days post procedure, and also underwent surgical removal with no residual AR. There was no cases of device embolization and no femoral arterial compromise. On median follow-up of 40.5\u00a0months (IQR 25\u201364), none of the patients developed complete heart block. Three patients (18.75%) had small residual shunts at latest follow-up which have not required any further intervention. Device closure of PMVSD\u2019s in children weighing\u2009\u2264\u200910\u00a0kg is feasible and safe with good procedural success rates. Use of both the antegrade and retrograde approaches may be necessary depending on anatomical variances.<\/jats:p>","DOI":"10.1007\/s00246-023-03100-5","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T18:03:20Z","timestamp":1674669800000},"page":"1176-1182","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transfemoral Perimembranous Ventricular Septal Defect Device Closure in Infants Weighing\u2009\u2264\u200910 kg"],"prefix":"10.1007","volume":"44","author":[{"given":"Dhafer","family":"Alshahrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niall","family":"Linnane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"McCrossan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Oslizlok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin J.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin P.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien P.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"issue":"3","key":"3100_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.21470\/1678-9741-2018-0299","volume":"34","author":"S Erg\u00fcn","year":"2019","unstructured":"Erg\u00fcn S, Gen\u00e7 SB, Yildiz O, \u00d6zt\u00fcrk E, Kafal\u0131 HC, Ayy\u0131ld\u0131z P et al (2019) Risk factors for major adverse events after surgical closure of ventricular septal defect in patients less than 1 year of age: a single-center retrospective. 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