{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:17:25Z","timestamp":1786979845700,"version":"build-2736575974"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00246-023-03156-3","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T06:02:49Z","timestamp":1682056969000},"page":"1389-1397","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Isosorbide DiNitrate Effect on Hemodynamic Profile, Liver Stiffness, and Exercise Tolerance in Fontan Circulation (The NEET Clinical Trial)"],"prefix":"10.1007","volume":"45","clinical-trial-number":[{"clinical-trial-number":"nct04297241","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1606-9144","authenticated-orcid":false,"given":"Amee M.","family":"Bigelow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle W.","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L. S.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Opotowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Lubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Dillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gruschen R.","family":"Veldtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh C.","family":"Heydarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Trout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ollberding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne A.","family":"Mays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Alsaied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"3156_CR1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000696","author":"J Rychik","year":"2019","unstructured":"Rychik J et al (2019) Evaluation and management of the child and adult with fontan circulation: A Scientific Statement From the American Heart Association. Circulation. https:\/\/doi.org\/10.1161\/CIR.0000000000000696","journal-title":"Circulation"},{"issue":"14","key":"3156_CR2","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1136\/heartjnl-2015-307467","volume":"102","author":"M Gewillig","year":"2016","unstructured":"Gewillig M, Brown SC (2016) The fontan circulation after 45 years: update in physiology. Heart 102(14):1081\u20131086","journal-title":"Heart"},{"issue":"2","key":"3156_CR3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1136\/heartjnl-2016-310108","volume":"103","author":"T Alsaied","year":"2017","unstructured":"Alsaied T et al (2017) Factors associated with long-term mortality after fontan procedures: a systematic review. Heart 103(2):104\u2013110","journal-title":"Heart"},{"issue":"7","key":"3156_CR4","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s00246-012-0315-7","volume":"33","author":"J Rychik","year":"2012","unstructured":"Rychik J et al (2012) The precarious state of the liver after a Fontan operation: summary of a multidisciplinary symposium. Pediatr Cardiol 33(7):1001\u20131012","journal-title":"Pediatr Cardiol"},{"issue":"9","key":"3156_CR5","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.amjcard.2019.07.052","volume":"124","author":"T Alsaied","year":"2019","unstructured":"Alsaied T et al (2019) Relation of magnetic resonance elastography to fontan failure and portal hypertension. Am J Cardiol 124(9):1454\u20131459","journal-title":"Am J Cardiol"},{"issue":"2","key":"3156_CR6","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1161\/01.CIR.93.2.266","volume":"93","author":"CJ Cooper","year":"1996","unstructured":"Cooper CJ et al (1996) Role of nitric oxide in the local regulation of pulmonary vascular resistance in humans. Circulation 93(2):266\u2013271","journal-title":"Circulation"},{"issue":"8","key":"3156_CR7","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1161\/CIRCULATIONAHA.119.044352","volume":"141","author":"DJ Goldberg","year":"2020","unstructured":"Goldberg DJ et al (2020) Results of the FUEL trial. Circulation 141(8):641\u2013651","journal-title":"Circulation"},{"issue":"18","key":"3156_CR8","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1161\/CIRCULATIONAHA.109.854331","volume":"120","author":"US Krishnan","year":"2009","unstructured":"Krishnan US et al (2009) Peripheral vascular adaptation and orthostatic tolerance in fontan physiology. Circulation 120(18):1775\u20131783","journal-title":"Circulation"},{"issue":"1","key":"3156_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1053\/j.pcsu.2015.01.004","volume":"18","author":"F De Rita","year":"2015","unstructured":"De Rita F et al (2015) Management of the failing fontan. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 18(1):2\u20136","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"3156_CR10","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317179","author":"K Colman","year":"2020","unstructured":"Colman K et al (2020) Peripheral venous pressure changes during exercise are associated with adverse fontan outcomes. Heart. https:\/\/doi.org\/10.1136\/heartjnl-2020-317179","journal-title":"Heart"},{"key":"3156_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijcard.2020.11.007","volume":"326","author":"W Tan","year":"2021","unstructured":"Tan W et al (2021) Peripheral venous pressure accurately predicts central venous pressure in the adult fontan circulation. Int J Cardiol 326:77\u201380","journal-title":"Int J Cardiol"},{"issue":"1","key":"3156_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00246-003-0438-y","volume":"25","author":"KA Milhoan","year":"2004","unstructured":"Milhoan KA et al (2004) Upper extremity peripheral venous pressure measurements accurately reflect pulmonary artery pressures in patients with cavopulmonary or fontan connections. Pediatr Cardiol 25(1):17\u201319","journal-title":"Pediatr Cardiol"},{"issue":"21","key":"3156_CR13","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1161\/CIRCULATIONAHA.110.012781","volume":"123","author":"RT Cole","year":"2011","unstructured":"Cole RT et al (2011) Hydralazine and isosorbide dinitrate in heart failure: historical perspective, mechanisms, and future directions. Circulation 123(21):2414\u20132422","journal-title":"Circulation"},{"issue":"5","key":"3156_CR14","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/BF00877117","volume":"8","author":"KE Torfgard","year":"1994","unstructured":"Torfgard KE, Ahlner J (1994) Mechanisms of action of nitrates. Cardiovasc Drugs Ther 8(5):701\u2013717","journal-title":"Cardiovasc Drugs Ther"},{"issue":"5","key":"3156_CR15","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.jtcvs.2015.08.002","volume":"150","author":"C Kurishima","year":"2015","unstructured":"Kurishima C et al (2015) Tailored therapy for aggressive dilatation of systemic veins and arteries may result in improved long-term fontan circulation. J Thorac Cardiovasc Surg 150(5):1367\u20131370","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"3156_CR16","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s11136-013-0581-8","volume":"23","author":"CB Forrest","year":"2014","unstructured":"Forrest CB et al (2014) Development of the PROMIS (R) pediatric global health (PGH-7) measure. Qual Life Res 23(4):1221\u20131231","journal-title":"Qual Life Res"},{"issue":"3","key":"3156_CR17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.2214\/AJR.19.21796","volume":"214","author":"AT Trout","year":"2020","unstructured":"Trout AT et al (2020) Liver shear wave speed and other quantitative ultrasound measures of liver parenchyma: prospective evaluation in healthy children and adults. AJR Am J Roentgenol 214(3):557\u2013565","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"3156_CR18","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s00246-020-02465-1","volume":"42","author":"DJ Goldberg","year":"2021","unstructured":"Goldberg DJ et al (2021) Exercise capacity and predictors of performance after fontan: results from the pediatric heart network fontan 3 study. Pediatr Cardiol 42(1):158\u2013168","journal-title":"Pediatr Cardiol"},{"key":"3156_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.11.121","author":"JM Karamichalis","year":"2020","unstructured":"Karamichalis JM (2020) Commentary: fontan circulation, pulmonary blood flow, and lessons from the FUEL (Fontan Udenafil Exercise Longitudinal) study. J Thorac Cardiovasc Surg. https:\/\/doi.org\/10.1016\/j.jtcvs.2020.11.121","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"3156_CR20","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jacc.2008.02.081","volume":"52","author":"SM Paridon","year":"2008","unstructured":"Paridon SM et al (2008) A cross-sectional study of exercise performance during the first 2 decades of life after the fontan operation. J Am Coll Cardiol 52(2):99\u2013107","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 3","key":"3156_CR21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1017\/S1047951105001629","volume":"15","author":"H Ohuchi","year":"2005","unstructured":"Ohuchi H (2005) Cardiopulmonary response to exercise in patients with the fontan circulation. Cardiol Young 15(Suppl 3):39\u201344","journal-title":"Cardiol Young"},{"issue":"3","key":"3156_CR22","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0167-5273(98)00249-6","volume":"66","author":"H Ohuchi","year":"1998","unstructured":"Ohuchi H et al (1998) Cardiorespiratory response during exercise in patients with cyanotic congenital heart disease with and without a fontan operation and in patients with congestive heart failure. Int J Cardiol 66(3):241\u2013251","journal-title":"Int J Cardiol"},{"issue":"1","key":"3156_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ijcard.2004.11.008","volume":"101","author":"H Ohuchi","year":"2005","unstructured":"Ohuchi H et al (2005) Post-exercise heart rate, blood pressure and oxygen uptake dynamics in pediatric patients with Fontan circulation comparison with patients after right ventricular outflow tract reconstruction. Int J Cardiol 101(1):129\u2013136","journal-title":"Int J Cardiol"},{"issue":"1","key":"3156_CR24","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000812","volume":"5","author":"S Udholm","year":"2018","unstructured":"Udholm S et al (2018) Prognostic power of cardiopulmonary exercise testing in fontan patients: a systematic review. Open Heart 5(1):e000812","journal-title":"Open Heart"},{"issue":"24","key":"3156_CR25","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1093\/eurheartj\/ehq356","volume":"31","author":"GP Diller","year":"2010","unstructured":"Diller GP et al (2010) Predictors of morbidity and mortality in contemporary fontan patients: results from a multicenter study including cardiopulmonary exercise testing in 321 patients. Eur Heart J 31(24):3073\u20133083","journal-title":"Eur Heart J"},{"issue":"6","key":"3156_CR26","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1017\/S1047951113001649","volume":"23","author":"DJ Goldberg","year":"2013","unstructured":"Goldberg DJ et al (2013) Exercise capacity in the Fontan circulation. Cardiol Young 23(6):824\u2013830","journal-title":"Cardiol Young"},{"issue":"10","key":"3156_CR27","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.amjcard.2016.02.042","volume":"117","author":"D Navaratnam","year":"2016","unstructured":"Navaratnam D et al (2016) Exercise-induced systemic venous hypertension in the fontan circulation. Am J Cardiol 117(10):1667\u20131671","journal-title":"Am J Cardiol"},{"issue":"2","key":"3156_CR28","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41569-019-0324-9","volume":"17","author":"GB Lim","year":"2020","unstructured":"Lim GB (2020) Udenafil to FUEL exercise performance in individuals with fontan physiology. Nat Rev Cardiol 17(2):72","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"3156_CR29","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/ALN.0b013e3181672607","volume":"108","author":"S Gelman","year":"2008","unstructured":"Gelman S (2008) Venous function and central venous pressure: a physiologic story. Anesthesiology 108(4):735\u2013748","journal-title":"Anesthesiology"},{"issue":"4","key":"3156_CR30","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1747-0803.2011.00500.x","volume":"6","author":"SM Fernandes","year":"2011","unstructured":"Fernandes SM et al (2011) Exercise testing identifies patients at increased risk for morbidity and mortality following Fontan surgery. Congenit Heart Dis 6(4):294\u2013303","journal-title":"Congenit Heart Dis"},{"issue":"9","key":"3156_CR31","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012008","volume":"8","author":"G Claessen","year":"2019","unstructured":"Claessen G et al (2019) Heart rate reserve in fontan patients: chronotropic incompetence or hemodynamic limitation? J Am Heart Assoc 8(9):e012008","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"3156_CR32","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.jtcvs.2016.11.061","volume":"153","author":"S Masutani","year":"2017","unstructured":"Masutani S et al (2017) Assessment of central venous physiology of fontan circulation using peripheral venous pressure. J Thorac Cardiovasc Surg 153(4):912\u2013920","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"25","key":"3156_CR33","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1016\/j.jacc.2017.10.045","volume":"70","author":"CJ Daniels","year":"2017","unstructured":"Daniels CJ et al (2017) Fontan-associated liver disease: Proceedings from the American College of Cardiology Stakeholders Meeting, October 1 to 2, 2015 Washington DC. J Am Coll Cardiol 70(25):3173\u20133194","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"3156_CR34","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1136\/hrt.2006.094516","volume":"93","author":"CH Kiesewetter","year":"2007","unstructured":"Kiesewetter CH et al (2007) Hepatic changes in the failing fontan circulation. Heart 93(5):579\u2013584","journal-title":"Heart"},{"issue":"5","key":"3156_CR35","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/chd.12159","volume":"9","author":"FM Wu","year":"2014","unstructured":"Wu FM et al (2014) Transient elastography may identify fontan patients with unfavorable hemodynamics and advanced hepatic fibrosis. Congenit Heart Dis 9(5):438\u2013447","journal-title":"Congenit Heart Dis"},{"key":"3156_CR36","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ijcard.2018.01.108","volume":"258","author":"A Egbe","year":"2018","unstructured":"Egbe A et al (2018) Temporal changes in liver stiffness after fontan operation: results of serial magnetic resonance elastography. Int J Cardiol 258:299\u2013304","journal-title":"Int J Cardiol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-023-03156-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-023-03156-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-023-03156-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T21:00:34Z","timestamp":1744146034000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-023-03156-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["3156"],"URL":"https:\/\/doi.org\/10.1007\/s00246-023-03156-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2444024\/v1","asserted-by":"object"}]},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]},"assertion":[{"value":"4 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. David Morales discloses the following: consultant for Berlin Heart, Inc.; proctor, consultant, and member of medical advisory board for Syncardia, Inc.; National PI for 50\/50\u00a0cc Syncardia Total Artificial Heart FDA Trial; consultant for Medtronic Inc. (HeartWare Division), consultant, educator, proctor for Abbott Medical, Inc. (Thoratec Division), consultant for Peca Graft Inc, consultant for Azyio Inc; consultant for Cormatrix Inc. Dr. Jonathan Dillman discloses the following: grant funding from Canon Medical Solutions, and Siemans Healthineers. Dr. Gruschen Veldtman discloses the follow: Consultant for Mezzion. Dr. Andrew Trout discloses the following: research funding from Canon Medical Solutions. Dr. Clifford Chin discloses the following: consultant for Azurity Pharmaceuticals. Drs. Amee Bigelow, Kyle Riggs, Adam Lubert, Alexander Opotowsky, Haleh Heydarian, David Cooper, Stuart Goldstein, Joseph Palermo, Nicholas Ollberding, and Tarek Alsaied have nothing to disclose. Mr. Wayne Mays has nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008, and has been approved by the institutional committee at Cincinnati Children\u2019s Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}