{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:42:24Z","timestamp":1776688944375,"version":"3.51.2"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s00246-023-03305-8","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:03:11Z","timestamp":1695819791000},"page":"133-142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluating Variation in the Cardiac Management of Children with Hereditary Thoracic Aortic Disease in the United States"],"prefix":"10.1007","volume":"45","author":[{"given":"Cassie N.","family":"Weyland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine B.","family":"Salciccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Beecroft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily N.","family":"Soludczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaine A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"issue":"24","key":"3305_CR1","doi-asserted-by":"publisher","first-page":"e223","DOI":"10.1016\/j.jacc.2022.08.004","volume":"80","author":"EM Isselbacher","year":"2022","unstructured":"Isselbacher EM, Preventza O, HamiltonBlack J III et al (2022) 2022 ACC\/AHA Guideline for the Diagnosis and Management of Aortic Disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 80(24):e223\u2013e393. https:\/\/doi.org\/10.1016\/j.jacc.2022.08.004","journal-title":"J Am Coll Cardiol"},{"issue":"19","key":"3305_CR2","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1056\/NEJM199405123301902","volume":"330","author":"J Shores","year":"1994","unstructured":"Shores J, Berger KR, Murphy EA, Pyeritz RE (1994) Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan\u2019s syndrome. N Engl J Med 330(19):1335\u20131341. https:\/\/doi.org\/10.1056\/NEJM199405123301902","journal-title":"N Engl J Med"},{"issue":"8","key":"3305_CR3","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1056\/NEJMoa055695","volume":"355","author":"BL Loeys","year":"2006","unstructured":"Loeys BL, Schwarze U, Holm T et al (2006) Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 355(8):788\u2013798","journal-title":"N Engl J Med"},{"issue":"2","key":"3305_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/SLA.0b013e31829c7a59","volume":"258","author":"D Bergqvist","year":"2013","unstructured":"Bergqvist D, Bj\u00f6rck M, Wanhainen A (2013) Treatment of vascular Ehlers\u2013Danlos syndrome: a systematic review. Ann Surg 258(2):257\u2013261. https:\/\/doi.org\/10.1097\/SLA.0b013e31829c7a59","journal-title":"Ann Surg"},{"issue":"4","key":"3305_CR5","doi-asserted-by":"publisher","first-page":"e1059","DOI":"10.1542\/peds.2013-2063","volume":"132","author":"BT Tinkle","year":"2013","unstructured":"Tinkle BT, Saal HM (2013) Health supervision for children with Marfan syndrome. Pediatrics 132(4):e1059\u2013e1072. https:\/\/doi.org\/10.1542\/peds.2013-2063","journal-title":"Pediatrics"},{"issue":"11","key":"3305_CR6","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1001\/archpedi.156.11.1086","volume":"156","author":"J Todd","year":"2002","unstructured":"Todd J, Bertoch D, Dolan S (2002) Use of a large national database for comparative evaluation of the effect of a bronchiolitis\/viral pneumonia clinical care guideline on patient outcome and resource utilization. Arch Pediatr Adolesc Med 156(11):1086\u20131090","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"21","key":"3305_CR7","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1016\/j.jacc.2015.09.032","volume":"66","author":"BJ Maron","year":"2015","unstructured":"Maron BJ, Zipes DP, Kovacs RJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: preamble, principles, and general considerations: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66(21):2343\u20132349","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"3305_CR8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/CRD.0000000000000081","volume":"24","author":"P Arscott","year":"2016","unstructured":"Arscott P, Caleshu C, Kotzer K et al (2016) A case for inclusion of genetic counselors in cardiac care. Cardiol Rev 24(2):49\u201355. https:\/\/doi.org\/10.1097\/CRD.0000000000000081","journal-title":"Cardiol Rev"},{"key":"3305_CR9","doi-asserted-by":"publisher","first-page":"16010","DOI":"10.1038\/npjgenmed.2016.10","volume":"1","author":"B Heald","year":"2016","unstructured":"Heald B, Rybicki L, Clements D et al (2016) Assessment of clinical workload for general and specialty genetic counsellors at an academic medical center: a tool for evaluating genetic counselling practices. NPJ Genom Med 1:16010","journal-title":"NPJ Genom Med"},{"issue":"3","key":"3305_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/00125817-200205000-00003","volume":"4","author":"RJ Wenstrup","year":"2002","unstructured":"Wenstrup RJ, Meyer RA, Lyle JS et al (2002) Prevalence of aortic root dilation in the Ehlers\u2013Danlos syndrome. Genet Med 4(3):112\u2013117. https:\/\/doi.org\/10.1097\/00125817-200205000-00003","journal-title":"Genet Med"},{"issue":"10","key":"3305_CR11","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1056\/NEJM200003093421001","volume":"342","author":"M Pepin","year":"2000","unstructured":"Pepin M, Schwarze U, Superti-Furga A, Byers PH (2000) Clinical and genetic features of Ehlers\u2013Danlos syndrome type IV, the vascular type. N Engl J Med 342(10):673\u2013680","journal-title":"N Engl J Med"},{"issue":"1","key":"3305_CR12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jvs.2005.03.053","volume":"42","author":"GS Oderich","year":"2005","unstructured":"Oderich GS, Panneton JM, Bower TC et al (2005) The spectrum, management and clinical outcome of Ehlers-Danlos syndrome type IV: a 30-year experience. J Vasc Surg 42(1):98\u2013106","journal-title":"J Vasc Surg"},{"issue":"12","key":"3305_CR13","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/gim.2014.72","volume":"16","author":"MG Pepin","year":"2014","unstructured":"Pepin MG, Schwarze U, Rice KM, Liu M, Leistritz D, Byers PH (2014) Survival is affected by mutation type and molecular mechanism in vascular Ehlers-Danlos syndrome (EDS type IV). Genet Med 16(12):881\u2013888. https:\/\/doi.org\/10.1038\/gim.2014.72","journal-title":"Genet Med"},{"issue":"10355","key":"3305_CR14","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0140-6736(22)01534-3","volume":"400","author":"A Pitcher","year":"2022","unstructured":"Pitcher A, Spata E, Emberson J et al (2022) Angiotensin receptor blockers and \u03b2 blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials. Lancet 400(10355):822\u2013831. https:\/\/doi.org\/10.1016\/S0140-6736(22)01534-3","journal-title":"Lancet"},{"key":"3305_CR15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.avsg.2021.12.073","volume":"82","author":"Z Wang","year":"2022","unstructured":"Wang Z, Deng X, Kang X, Hu A (2022) Angiotensin receptor blockers vs. beta-blocker therapy for Marfan syndrome: a systematic review and meta-analysis. Ann Vasc Surg 82:347\u2013361","journal-title":"Ann Vasc Surg"},{"issue":"22","key":"3305_CR16","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","volume":"371","author":"RV Lacro","year":"2014","unstructured":"Lacro RV, Dietz HC, Sleeper LA et al (2014) Atenolol versus losartan in children and young adults with Marfan\u2019s syndrome. N Engl J 371(22):2061\u20132071. https:\/\/doi.org\/10.1056\/NEJMoa1404731","journal-title":"N Engl J"},{"issue":"45","key":"3305_CR17","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1093\/eurheartj\/eht334","volume":"34","author":"M Groenink","year":"2013","unstructured":"Groenink M, den Hartog AW, Franken R et al (2013) Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Eur Heart J 34(45):3491\u20133500. https:\/\/doi.org\/10.1093\/eurheartj\/eht334","journal-title":"Eur Heart J"},{"issue":"2","key":"3305_CR18","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1161\/CIRCGENETICS.114.000950","volume":"8","author":"R Franken","year":"2015","unstructured":"Franken R, den Hartog AW, Radonic T et al (2015) Beneficial outcome of losartan therapy depends on type of FBN1 mutation in Marfan syndrome. Circ Cardiovasc Genet 8(2):383\u2013388. https:\/\/doi.org\/10.1161\/CIRCGENETICS.114.000950","journal-title":"Circ Cardiovasc Genet"},{"issue":"3","key":"3305_CR19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mayocp.2012.11.005","volume":"88","author":"HH Chiu","year":"2013","unstructured":"Chiu HH, Wu MH, Wang JK et al (2013) Losartan added to \u03b2-blockade therapy for aortic root dilation in Marfan syndrome: a randomized, open-label pilot study. Mayo Clin Proc 88(3):271\u2013276","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"3305_CR20","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1080\/00015385.2017.1314134","volume":"72","author":"L Mui\u00f1o-Mosquera","year":"2017","unstructured":"Mui\u00f1o-Mosquera L, De Nobele S, Devos D, Campens L, De Paepe A, De Backer J (2017) Efficacy of losartan as add-on therapy to prevent aortic growth and ventricular dysfunction in patients with Marfan syndrome: a randomized, double-blind clinical trial. Acta Cardiol 72(6):616\u2013624. https:\/\/doi.org\/10.1080\/00015385.2017.1314134","journal-title":"Acta Cardiol"},{"issue":"32","key":"3305_CR21","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1093\/eurheartj\/ehv151","volume":"36","author":"O Milleron","year":"2015","unstructured":"Milleron O, Arnoult F, Ropers J et al (2015) Marfan Sartan: a randomized, double-blind, placebo-controlled trial. Eur Heart J 36(32):2160\u20132166. https:\/\/doi.org\/10.1093\/eurheartj\/ehv151","journal-title":"Eur Heart J"},{"issue":"10","key":"3305_CR22","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.amjcard.2005.06.094","volume":"96","author":"LJ Meijboom","year":"2005","unstructured":"Meijboom LJ, Timmermans J, Zwinderman AH, Engelfriet PM, Mulder BJ (2005) Aortic root growth in men and women with the Marfan\u2019s syndrome. Am J Cardiol 96(10):1441\u20131444","journal-title":"Am J Cardiol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-023-03305-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-023-03305-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-023-03305-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:03:24Z","timestamp":1704809004000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-023-03305-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["3305"],"URL":"https:\/\/doi.org\/10.1007\/s00246-023-03305-8","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,27]]},"assertion":[{"value":"22 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}