{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:17:25Z","timestamp":1786979845732,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Gusu Health Talent Foundation","award":["GSWS2020054"],"award-info":[{"award-number":["GSWS2020054"]}]},{"name":"the Suzhou Science and Technology Bureau Science and Technology Development Plan","award":["SS2020066"],"award-info":[{"award-number":["SS2020066"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00246-023-03357-w","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T03:48:41Z","timestamp":1703130521000},"page":"163-172","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myocardial Work for Dynamic Monitoring of Myocardial Injury in Neonatal Asphyxia"],"prefix":"10.1007","volume":"46","author":[{"given":"Xin-Lu","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Cheng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Yue","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ying","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Qin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"issue":"01","key":"3357_CR1","first-page":"3","volume":"19","author":"RJ Yu","year":"2016","unstructured":"Yu RJ, Ye HM, Zhu JX (2016) Expert consensus on the diagnosis of neonatal asphyxia. Chinese J Perinat Med 19(01):3\u20136","journal-title":"Chinese J Perinat Med"},{"issue":"01","key":"3357_CR2","first-page":"1","volume":"15","author":"ZL Chen","year":"2013","unstructured":"Chen ZL, Liu J, Feng ZC (2013) Recommendation on the diagnosis and classification standard of neonatal asphyxia. Chinese J Contemp Pediatr 15(01):1","journal-title":"Chinese J Contemp Pediatr"},{"key":"3357_CR3","doi-asserted-by":"publisher","first-page":"F152","DOI":"10.1136\/adc.2002.023093","volume":"89","author":"P Shah","year":"2004","unstructured":"Shah P, Riphagen S, Beyene J, Perlman M (2004) Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 89:F152\u2013F155","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"3357_CR4","first-page":"688","volume":"99","author":"GD Hankins","year":"2002","unstructured":"Hankins GD, Koen S, Gei AF, Lopez SM, Van Hook JW, Anderson GD (2002) Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy. Obstet Gynecol 99:688\u2013691","journal-title":"Obstet Gynecol"},{"key":"3357_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0378-3782(91)90191-5","volume":"25","author":"S Shankaran","year":"1991","unstructured":"Shankaran S, Woldt E, Koepke T, Bedard MP, Nandyal R (1991) Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Human Dev 25:135\u2013148","journal-title":"Early Human Dev"},{"key":"3357_CR6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fped.2018.00363","volume":"6","author":"C Joynt","year":"2018","unstructured":"Joynt C, Cheung PY (2018) Cardiovascular supportive therapies for neonates with asphyxia\u2014a literature review of pre-clinical and clinical studies. Front Pediatr 6:363","journal-title":"Front Pediatr"},{"issue":"03","key":"3357_CR7","first-page":"172","volume":"14","author":"B Miao","year":"2012","unstructured":"Miao B, Sun B, Feng X (2012) Treatment of myocardial damage with creatine phosphate following neonatal asphyxia: a meta-analysis. Chinese J Contemp Pediatr 14(03):172\u2013176","journal-title":"Chinese J Contemp Pediatr"},{"key":"3357_CR8","first-page":"252","volume":"159","author":"DW Kehl","year":"2012","unstructured":"Kehl DW, Iqbal N, Fard A, Kipper BA, De La Parra LA, Maisel AS (2012) Biomarkers in acute myocardial injury. Trans Res J Lab Clin Med 159:252\u2013264","journal-title":"Trans Res J Lab Clin Med"},{"issue":"657\u201381","key":"3357_CR9","first-page":"xi","volume":"91","author":"AK Saenger","year":"2007","unstructured":"Saenger AK, Jaffe AS (2007) The use of biomarkers for the evaluation and treatment of patients with acute coronary syndromes. Med Clin North Am 91(657\u201381):xi","journal-title":"Med Clin North Am"},{"issue":"04","key":"3357_CR10","first-page":"241","volume":"19","author":"RJ Yu","year":"2016","unstructured":"Yu RJ, Wang JY, Liu SF (2016) Clinical diagnostic criteria of multiple organ damage in neonatal asphyxia. Chinese J Perinat Med 19(04):241\u2013242","journal-title":"Chinese J Perinat Med"},{"key":"3357_CR11","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1080\/20469047.2019.1641004","volume":"39","author":"H Bhasin","year":"2019","unstructured":"Bhasin H (2019) Echocardiographic assessment of myocardial dysfunction in perinatal asphyxia. Paediatr Int Child Health 39:304","journal-title":"Paediatr Int Child Health"},{"key":"3357_CR12","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1016\/j.jpeds.2010.11.005","volume":"158","author":"TA Leone","year":"2011","unstructured":"Leone TA, Finer NN (2011) Shock: a common consequence of neonatal asphyxia. J Pediatr 158:e9-12","journal-title":"J Pediatr"},{"key":"3357_CR13","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00246-009-9421-6","volume":"30","author":"Y Wei","year":"2009","unstructured":"Wei Y, Xu J, Xu T, Fan J, Tao S (2009) Left ventricular systolic function of newborns with asphyxia evaluated by tissue Doppler imaging. Pediatr Cardiol 30:741\u2013746","journal-title":"Pediatr Cardiol"},{"key":"3357_CR14","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1093\/eurheartj\/ehs016","volume":"33","author":"K Russell","year":"2012","unstructured":"Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme EW et al (2012) A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work. Eur Heart J 33:724\u2013733","journal-title":"Eur Heart J"},{"key":"3357_CR15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1093\/ehjci\/jeaa175","volume":"22","author":"RP Lustosa","year":"2021","unstructured":"Lustosa RP, Fortuni F, van der Bijl P, Goedemans L, El Mahdiui M, Montero-Cabezas JM et al (2021) Left ventricular myocardial work in the culprit vessel territory and impact on left ventricular remodelling in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention. Eur Heart J Cardiovasc Imaging 22:339\u2013347","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"3357_CR16","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.echo.2020.07.008","volume":"33","author":"P Meimoun","year":"2020","unstructured":"Meimoun P, Abdani S, Stracchi V, Elmkies F, Boulanger J, Botoro T et al (2020) Usefulness of noninvasive myocardial work to predict left ventricular recovery and acute complications after acute anterior myocardial infarction treated by percutaneous coronary intervention. J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr 33:1180\u20131190","journal-title":"J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr"},{"key":"3357_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/ehjci\/jey131","volume":"20","author":"J Chan","year":"2019","unstructured":"Chan J, Edwards NFA, Khandheria BK, Shiino K, Sabapathy S, Anderson B et al (2019) A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging 20:31\u201339","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"3357_CR18","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1093\/ehjci\/jev078","volume":"16","author":"E Boe","year":"2015","unstructured":"Boe E, Russell K, Eek C, Eriksen M, Remme EW, Smiseth OA et al (2015) Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome. Eur Heart J Cardiovasc Imaging 16:1247\u20131255","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"3357_CR19","unstructured":"(2020) Guidelines for Clinical application of echocardiography in the assessment of cardiac systolic and diastolic function. Chinese J Ultrasonogr. 29(06):461\u201377"},{"issue":"5","key":"3357_CR20","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.echo.2010.03.019","volume":"23","author":"L Lopez","year":"2010","unstructured":"Lopez L, Colan SD, Frommelt PC, Ensing GJ, Kendall K, Younoszai AK, Lai WW, Geva T (2010) Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the pediatric measurements writing group of the American society of echocardiography pediatric and congenital heart disease council. J Am Soc Echocardiogr 23(5):465\u2013495","journal-title":"J Am Soc Echocardiogr"},{"key":"3357_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jpeds.2020.02.072","volume":"221","author":"JM Dionne","year":"2020","unstructured":"Dionne JM, Bremner SA, Baygani SK, Batton B, Ergenekon E, Bhatt-Mehta V et al (2020) Method of blood pressure measurement in neonates and infants: a systematic review and analysis. J Pediatr 221:23-31.e5","journal-title":"J Pediatr"},{"key":"3357_CR22","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1161\/CIR.0000000000000682","volume":"140","author":"SE Lipshultz","year":"2019","unstructured":"Lipshultz SE, Law YM, Asante-Korang A, Austin ED, Dipchand AI, Everitt MD et al (2019) Cardiomyopathy in children: classification and diagnosis: a scientific statement from the American heart association. Circulation 140:e9\u2013e68","journal-title":"Circulation"},{"issue":"2","key":"3357_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/medicina54020012","volume":"54","author":"S Gurgul","year":"2018","unstructured":"Gurgul S, Buyukakilli B, Komur M, Okuyaz C, Balli E, Ozcan T (2018) Does Levetiracetam administration prevent cardiac damage in adulthood rats following neonatal hypoxia\/ischemia-induced brain injury? Medicina 54(2):12","journal-title":"Medicina"},{"key":"3357_CR24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fped.2020.00068","volume":"8","author":"MR Popescu","year":"2020","unstructured":"Popescu MR, Panaitescu AM, Pavel B, Zagrean L, Peltecu G, Zagrean AM (2020) Getting an early start in understanding perinatal asphyxia impact on the cardiovascular system. Front Pediatr 8:68","journal-title":"Front Pediatr"},{"key":"3357_CR25","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1139\/y2012-041","volume":"90","author":"RS Gill","year":"2012","unstructured":"Gill RS, Pelletier JS, LaBossiere J, Bigam DL, Cheung PY (2012) Therapeutic strategies to protect the immature newborn myocardium during resuscitation following asphyxia. Can J Physiol Pharmacol 90:689\u2013695","journal-title":"Can J Physiol Pharmacol"},{"key":"3357_CR26","doi-asserted-by":"publisher","first-page":"691611","DOI":"10.3389\/fcvm.2021.691611","volume":"8","author":"F Hedwig","year":"2021","unstructured":"Hedwig F, Nemchyna O, Stein J, Knosalla C, Merke N, Knebel F et al (2021) Myocardial work assessment for the prediction of prognosis in advanced heart failure. Front Cardiovasc Med 8:691611","journal-title":"Front Cardiovasc Med"},{"key":"3357_CR27","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.siny.2006.01.002","volume":"11","author":"JM Fanaroff","year":"2006","unstructured":"Fanaroff JM, Fanaroff AA (2006) Blood pressure disorders in the neonate: hypotension and hypertension. Semin Fetal Neonatal Med 11:174\u2013181","journal-title":"Semin Fetal Neonatal Med"},{"key":"3357_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1053\/j.semperi.2003.11.004","volume":"28","author":"JE Jones","year":"2004","unstructured":"Jones JE, Jose PA (2004) Neonatal blood pressure regulation. Semin Perinatol 28:141\u2013148","journal-title":"Semin Perinatol"},{"key":"3357_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.clp.2020.05.008","volume":"47","author":"B Batton","year":"2020","unstructured":"Batton B (2020) Neonatal blood pressure standards: what is \u201cnormal\u201d? Clin Perinatol 47:469\u2013485","journal-title":"Clin Perinatol"},{"issue":"4","key":"3357_CR30","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.echo.2010.02.015","volume":"23","author":"H Geyer","year":"2010","unstructured":"Geyer H, Caracciolo G, Abe H, Wilansky S, Carerj S, Gentile F, Nesser HJ, Khandheria B, Narula J, Sengupta PP (2010) Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr 23(4):351\u2013369","journal-title":"J Am Soc Echocardiogr"},{"key":"3357_CR31","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1542\/peds.112.4.896","volume":"112","author":"TS Mir","year":"2003","unstructured":"Mir TS, Laux R, Hellwege HH, Liedke B, Heinze C, von Buelow H et al (2003) Plasma concentrations of aminoterminal pro atrial natriuretic peptide and aminoterminal pro brain natriuretic peptide in healthy neonates: marked and rapid increase after birth. Pediatrics 112:896\u2013899","journal-title":"Pediatrics"},{"key":"3357_CR32","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1136\/heart.89.8.875","volume":"89","author":"A Koch","year":"2003","unstructured":"Koch A, Singer H (2003) Normal values of B type natriuretic peptide in infants, children, and adolescents. Heart British Cardiac Soc 89:875\u2013878","journal-title":"Heart British Cardiac Soc"},{"key":"3357_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.pedneo.2015.08.001","volume":"57","author":"R Zhu","year":"2016","unstructured":"Zhu R, Nie Z (2016) A clinical study of the N-terminal pro-brain natriuretic peptide in myocardial injury after neonatal asphyxia. Pediatr Neonatol 57:133\u2013139","journal-title":"Pediatr Neonatol"},{"issue":"4","key":"3357_CR34","first-page":"252","volume":"12","author":"LX Lin","year":"2010","unstructured":"Lin LX, Mao QH, Zhang ZL, An CX, Kang XG (2010) Plasma levels of N-terminal pro-brain natriuretic peptide and glycogen phosphorylase isoenzyme BB in neonates with asphyxia complicated by myocardial injury. Zhongguo Dang dai er ke za zhi= Chinese J Contemp Pediatr 12(4):252\u2013255","journal-title":"Zhongguo Dang dai er ke za zhi= Chinese J Contemp Pediatr"},{"key":"3357_CR35","doi-asserted-by":"publisher","first-page":"62","DOI":"10.11152\/mu-2672","volume":"23","author":"R Tomoaia","year":"2021","unstructured":"Tomoaia R, Beyer RS, Zdrenghea D, Dadarlat-Pop A, Cismaru G, Gusetu G et al (2021) Global work index by non-invasive pressure-strain loops: a novel parameter to assess left ventricular performance in the early stages of heart failure with preserved or mid-range ejection fraction after acute myocardial infarction. Med Ultrason 23:62\u201369","journal-title":"Med Ultrason"},{"issue":"2","key":"3357_CR36","doi-asserted-by":"publisher","first-page":"e001346","DOI":"10.1136\/openhrt-2020-001346","volume":"7","author":"A Roger-Roll\u00e9","year":"2020","unstructured":"Roger-Roll\u00e9 A, Cariou E, Rguez K, Fournier P, Lavie-Badie Y, Blanchard V, Roncalli J, Galinier M, Carri\u00e9 D, Lairez O (2020) Can myocardial work indices contribute to the exploration of patients with cardiac amyloidosis? Open Heart. 7(2):e001346","journal-title":"Open Heart."},{"key":"3357_CR37","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/echo.14612","volume":"37","author":"F Hedwig","year":"2020","unstructured":"Hedwig F, Soltani S, Stein J, Schoenrath F, Potapov E, Knosalla C et al (2020) Global work index correlates with established prognostic parameters of heart failure. Echocardiogr Mount Kisco NY 37:412\u2013420","journal-title":"Echocardiogr Mount Kisco NY"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-023-03357-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-023-03357-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-023-03357-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T11:33:23Z","timestamp":1737372803000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-023-03357-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3357"],"URL":"https:\/\/doi.org\/10.1007\/s00246-023-03357-w","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,20]]},"assertion":[{"value":"12 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of Children\u2019s Hospital of Soochow University (2021CS151).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from legal guardians and the study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in a priori approval by the institution's human research committee.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}