{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:38:48Z","timestamp":1790609928614,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of California San Francisco California Preterm Birth Initiative"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u00a0In neonatal, symptomatic tetralogy of Fallot (sTOF), data are lacking on whether high-risk groups would benefit from staged (SR) or complete repair (CR). We studied the association of gestational age (GA) at birth and z-score for birth weight (BWz), with management strategy and outcomes in sTOF.\u00a0California population-based cohort study (2011\u20132017) of infants with sTOF (defined as catheter or surgical intervention prior to 44\u00a0weeks corrected GA) was performed, comparing management strategy and timing by GA and BWz categories. Multivariable models evaluated composite outcomes and days alive and out of hospital (DAOOH) in the first year of life.\u00a0Among 345 patients (SR\u00a0=\u00a0194; CR\u00a0=\u00a0151), management strategy did not differ by GA or BWz with complete repair defined as prior to 44\u00a0weeks corrected gestational age; however, did differ by GA with regard to complete\/timely repair (defined as complete repair within first 30\u00a0days of life). Full-term and early-term neonates underwent CR 20 (95%CI:\u2009\u2212\u200927.1,\u2009\u2212\u200914.1; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) and 15\u00a0days (95%CI:\u2009\u2212\u200922.1,\u2009\u2212\u20098.2; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) sooner than preterm neonates. Prematurity and major anomaly were associated with mortality or non-cardiac morbidity, while only major anomaly was associated with mortality or cardiac morbidity (OR\u00a0=\u00a03.5, 95%CI: 1.8,6.7, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.0001). Full-term infants had greater DAOOH compared to preterm infants (35.2\u00a0days, 95%CI: 4.0, 66.5, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). LGA infants and those with major anomaly had significantly lower DAOOH.\u00a0In sTOF, patient specific risk factors such as prematurity and major anomaly were more associated with outcomes than management strategy.<\/jats:p>","DOI":"10.1007\/s00246-023-03365-w","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T17:32:28Z","timestamp":1704216748000},"page":"300-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Association of Gestational Age and Size with Management Strategies and Outcomes in Symptomatic Neonatal Tetralogy of Fallot"],"prefix":"10.1007","volume":"45","author":[{"given":"Leanne","family":"Duhaney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina A.","family":"Steurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Baer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Rajagopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Mercer-Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Mohan","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Jelliffe-Pawlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Peyvandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"12","key":"3365_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2019.05.057","volume":"74","author":"JJ Savla","year":"2019","unstructured":"Savla JJ, Faeber JA, Huang YV, Zaoutis T, Goldmuntz E, Kawut SM et al (2019) 2-year outcomes after complete or staged procedure for tetralogy of Fallot in neonates. 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