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Combined assessment of cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in this context have not been fully explored. To evaluate cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in patients who have undergone Fontan procedures. Thirty-eight patients and 23 controls underwent cardiac and liver MRI examinations in a 3.0-T scanner. Mann\u2013Whitney, Fisher exact test, and Spearman\u2019s correlation were applied to evaluate myocardial volumes, function, native cardiac and liver T1 mapping, ECVs and liver stiffness. The mean native cardiac T1 value (<jats:italic>p<\/jats:italic>\u2009=\u20090.018), cardiac ECV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), liver native T1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), liver ECV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and liver stiffness (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were higher in patients than controls. The indexed end-diastolic volume (EDVi) correlated with the myocardial ECV (<jats:italic>r<\/jats:italic>\u2009=\u20090.356; <jats:italic>p<\/jats:italic>\u2009=\u20090.033), native liver T1 (<jats:italic>r<\/jats:italic>\u2009=\u20090.571; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and with liver stiffness (<jats:italic>r<\/jats:italic>\u2009=\u20090.391; <jats:italic>p<\/jats:italic>\u2009=\u20090.015). In addition, liver stiffness correlated with liver ECV (<jats:italic>r<\/jats:italic>\u2009=\u20090.361; <jats:italic>p<\/jats:italic>\u2009=\u20090.031) and native liver T1 (<jats:italic>r<\/jats:italic>\u2009=\u20090.458; <jats:italic>p<\/jats:italic>\u2009=\u20090.004). An association between cardiac remodeling and cardiac and liver fibrosis were found in this population. The usefulness of MRI to follow cardiac and liver involvement in these patients is critical to improve treatment strategies and to prevent the need for combined liver and heart transplantation.<\/jats:p>","DOI":"10.1007\/s00246-024-03522-9","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T06:01:36Z","timestamp":1716271296000},"page":"966-975","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation"],"prefix":"10.1007","volume":"46","author":[{"given":"Adriana","family":"Innocenzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"P\u00f3voa-Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella Braz","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana Souza","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Tomoko","family":"Fukuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Machado","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Ara\u00fajo","family":"Oliveira Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Silvestre de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronir Raggio","family":"Luiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa C\u00e9lia Pimentel","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Cordeiro","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Moll-Bernardes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"3522_CR1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000696","author":"J Rychik","year":"2019","unstructured":"Rychik J, Atz AM, Celermajer DS et al (2019) Evaluation and management of the child and adult with Fontan circulation: a scientific statement from the American heart association. 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