{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:31:19Z","timestamp":1776785479406,"version":"3.51.2"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00246-024-03524-7","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T07:02:04Z","timestamp":1719558124000},"page":"985-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiopulmonary Exercise Testing in Children and Adolescents with Repaired Tetralogy of Fallot: Mechanisms of Exercise Intolerance and Clinical Implications"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-2394","authenticated-orcid":false,"given":"Danton","family":"MHD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadjisoteriou","family":"A","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noonan","family":"P","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"D","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burns","family":"P","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"3","key":"3524_CR1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/heartjnl-2020-318928","volume":"108","author":"G Eshuis","year":"2022","unstructured":"Eshuis G, Hock J, Marchie du Sarvaas G et al (2022) Exercise capacity in patients with repaired tetralogy of fallot aged 6 to 63 years. Heart 108(3):186\u2013193","journal-title":"Heart"},{"key":"3524_CR2","doi-asserted-by":"crossref","unstructured":"Rhodes J, Alexander ME, Opotowsky A. Exercise Physiology for the Paediatric and Congenital Cardiologist 1st ed: Springer International Publishing 2019.","DOI":"10.1007\/978-3-030-16818-6"},{"issue":"4","key":"3524_CR3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/eurheartj\/ehn531","volume":"30","author":"A Gratz","year":"2009","unstructured":"Gratz A, Hess J, Hager A (2009) Self-estimated physical functioning poorly predicts actual exercise capacity in adolescents and adults with congenital heart disease. Eur Heart J 30(4):497\u2013504","journal-title":"Eur Heart J"},{"issue":"8","key":"3524_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1047951121000238","volume":"31","author":"RJ Dobson","year":"2021","unstructured":"Dobson RJ, Ramparsad N, Walker NL, McConnachie A, Danton MHD (2021) Outcomes of adults with repaired tetralogy of Fallot from the national scottish cohort. Cardiol Young 31(8):1\u20139","journal-title":"Cardiol Young"},{"key":"3524_CR5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1148\/radiol.2231010924","volume":"223","author":"AA Roest","year":"2002","unstructured":"Roest AA, Helbing WA, Kunz P et al (2002) Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function in patients after tetralogy of Fallot repair. Radiology 223:204\u2013211","journal-title":"Radiology"},{"issue":"1","key":"3524_CR6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ihj.2017.07.021","volume":"70","author":"N Dluzniewska","year":"2018","unstructured":"Dluzniewska N, Podolec P, Miszalski-Jamka T et al (2018) Effect of ventricular function and volumes on exercise capacity in adults with repaired tetralogy of Fallot. Indian Heart J 70(1):87\u201392","journal-title":"Indian Heart J"},{"key":"3524_CR7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ahj.2008.02.005","volume":"156","author":"A Samman","year":"2008","unstructured":"Samman A, Ballint OH, Tanous D et al (2008) Exercise capacity and biventricular function in adults with repaired tetralogy of Fallot. Am Heart J 156:100\u2013105","journal-title":"Am Heart J"},{"key":"3524_CR8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijcard.2015.05.174","volume":"196","author":"J Muller","year":"2015","unstructured":"Muller J, Hager A, Diller GP et al (2015) Peak oxygen uptake, ventilatory efficiency and QRS-duration predict event free survival in patients late after surgical repair of tetralogy of Fallot. Int J Cardiol 196:158\u2013164","journal-title":"Int J Cardiol"},{"key":"3524_CR9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0002-9149(00)00732-3","volume":"85","author":"H Ohuchi","year":"2000","unstructured":"Ohuchi H, Yasuda K, Suzuki H, Arakaki Y, Yagihara T, Echigo S (2000) Ventilatory responses to exercise in patients with major aortopulmonary collaterall arteries after definitive surgery. Am J Cardiol 85:1223\u20131229","journal-title":"Am J Cardiol"},{"key":"3524_CR10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijcard.2019.10.032","volume":"300","author":"L Guirgis","year":"2020","unstructured":"Guirgis L, Khraiche D, Ladouceur M, Iserin L, Bonnet D, Legendre A (2020) Cardiac performance assessment during cardiopulmonary exercise test can improve the management of children with repaired congenital heart disease. Int J Cardiol 300:121\u2013126","journal-title":"Int J Cardiol"},{"issue":"8","key":"3524_CR11","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00246-017-1697-3","volume":"38","author":"C Meierhofer","year":"2017","unstructured":"Meierhofer C, Tavakkoli T, Kuhn A et al (2017) Importance of non-invasive right and left ventricular variables on exercise capacity in patients with tetralogy of Fallot hemodynamics. Pediatr Cardiol 38(8):1569\u20131574","journal-title":"Pediatr Cardiol"},{"key":"3524_CR12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/CIRCULATIONAHA.111.058719","volume":"125","author":"R Inuzuka","year":"2012","unstructured":"Inuzuka R, Diller G-P, Borgia F et al (2012) Comprehensive use of cardiopulmonary exercise testing identifies adults with congenital heart disease at increased mortality risk in the medium term. Circulation 125:250\u2013259","journal-title":"Circulation"},{"issue":"3","key":"3524_CR13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/heartjnl-2013-304958","volume":"100","author":"AM Valente","year":"2014","unstructured":"Valente AM, Gauvreau K, Assenza GE et al (2014) Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort. Heart 100(3):247\u2013253","journal-title":"Heart"},{"issue":"6","key":"3524_CR14","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/CIRCULATIONAHA.104.529800","volume":"112","author":"GP Diller","year":"2005","unstructured":"Diller GP, Dimopoulos K, Okonko D et al (2005) Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication. Circulation 112(6):828\u2013835","journal-title":"Circulation"},{"issue":"18","key":"3524_CR15","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/CIRCULATIONAHA.117.027402","volume":"136","author":"EL Heng","year":"2017","unstructured":"Heng EL, Gatzoulis MA, Uebing A et al (2017) Immediate and midterm cardiac remodeling after surgical pulmonary valve replacement in adults with repaired tetralogy of Fallot: a prospective cardiovascular magnetic resonance and clinical study. Circulation 136(18):1703\u20131713","journal-title":"Circulation"},{"issue":"6","key":"3524_CR16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cjcpc.2023.10.007","volume":"2","author":"B Leonardi","year":"2023","unstructured":"Leonardi B, Cifra B (2023) The role of cardiopulmonary testing to risk stratify tetralogy of Fallot patients. CJC Pediatr Congenit Heart Dis. 2(6):314\u2013321","journal-title":"CJC Pediatr Congenit Heart Dis."},{"issue":"1","key":"3524_CR17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijcard.2008.01.032","volume":"134","author":"GP Diller","year":"2009","unstructured":"Diller GP, Okonko DO, Uebing A et al (2009) Impaired heart rate response to exercise in adult patients with a systemic right ventricle or univentricular circulation: prevalence, relation to exercise, and potential therapeutic implications. Int J Cardiol 134(1):59\u201366","journal-title":"Int J Cardiol"},{"key":"3524_CR18","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.874700","volume":"9","author":"Y Villaseca-Rojas","year":"2022","unstructured":"Villaseca-Rojas Y, Varela-Melo J, Torres-Castro R et al (2022) Exercise capacity in children and adolescents with congenital heart disease: a systematic review and meta-analysis. Front Cardiovasc Med 9:874700","journal-title":"Front Cardiovasc Med"},{"issue":"10","key":"3524_CR19","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1111\/jce.14043","volume":"30","author":"S Franciosi","year":"2019","unstructured":"Franciosi S, Roston TM, Perry FKG, Knollmann BC, Kannankeril PJ, Sanatani S (2019) Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol 30(10):1923\u20131929","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"4","key":"3524_CR20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jchf.2015.11.003","volume":"4","author":"A Barron","year":"2016","unstructured":"Barron A, Francis DP, Mayet J et al (2016) Oxygen uptake efficiency slope and breathing reserve, not anaerobic threshold, discriminate between patients with cardiovascular disease over chronic obstructive pulmonary disease. JACC Heart Fail 4(4):252\u2013261","journal-title":"JACC Heart Fail"},{"key":"3524_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcchd.2020.100050","author":"S Alborikan","year":"2020","unstructured":"Alborikan S, Pandya B, Von Klemperer K et al (2020) Cardiopulmonary exercise test (CPET) in patients with repaired tetralogy of Fallot (rTOF); a systematic review. Int J Cardiol Congenit Heart Dis. https:\/\/doi.org\/10.1016\/j.ijcchd.2020.100050","journal-title":"Int J Cardiol Congenit Heart Dis."},{"issue":"3","key":"3524_CR22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s002460010041","volume":"21","author":"B Sarubbi","year":"2000","unstructured":"Sarubbi B, Pacileo G, Pisacane C et al (2000) Exercise capacity in young patients after total repair of tetralogy of Fallot. Pediatr Cardiol 21(3):211\u2013215","journal-title":"Pediatr Cardiol"},{"key":"3524_CR23","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201611-912FR","author":"T Takken","year":"2017","unstructured":"Takken T, Bongers BC, van Brussel M, Haapala EA, Hulzebos EHJ (2017) Cardiopulmonary exercise testing in pediatrics. Ann Am Thorac Soc. https:\/\/doi.org\/10.1513\/AnnalsATS.201611-912FR","journal-title":"Ann Am Thorac Soc"},{"issue":"9","key":"3524_CR24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1203\/00006450-198409000-00008","volume":"18","author":"DM Cooper","year":"1984","unstructured":"Cooper DM, Weiler-Ravell D, Whipp BJ, Wasserman K (1984) Growth-related changes in oxygen uptake and heart rate during progressive exercise in children. Pediatr Res 18(9):845\u2013851","journal-title":"Pediatr Res"},{"key":"3524_CR25","unstructured":"CDC. BMI Percentile Calculator for Child and Teen. https:\/\/www.cdc.gov\/healthyweight\/bmi\/calculator.html. Accessed 2023"},{"issue":"6","key":"3524_CR26","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1152\/jappl.1986.60.6.2020","volume":"60","author":"LW Beaver","year":"1986","unstructured":"Beaver LW, Wasserman K, Whipp BJ (1986) A new method of detecting anaerobic threshold by gas exchange. J Appl Physiol 60(6):2020\u20132027","journal-title":"J Appl Physiol"},{"issue":"6","key":"3524_CR27","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1249\/MSS.0000000000001559","volume":"50","author":"J Blanchard","year":"2018","unstructured":"Blanchard J, Blais S, Chetaille P et al (2018) New reference values for cardiopulmonary exercise testing in children. Med Sci Sports Exerc 50(6):1125\u20131133","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"3524_CR28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0735-1097(00)00691-4","volume":"36","author":"M Hollenberg","year":"2000","unstructured":"Hollenberg M, Tager IB (2000) Oxygen uptake efficiency slope: an index of exercise performance and cardiopulmonary reserve requiring only submaximal exercise. J Am Coll Cardiol 36(1):194\u2013201","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"3524_CR29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jacc.2004.02.060","volume":"44","author":"B Azarbal","year":"2004","unstructured":"Azarbal B, Hayes SW, Lewin HC, Hachamovitch R, Cohen I, Berman DS (2004) The incremental prognostic value of percentage of heart rate reserve achieved over myocardial perfusion single-photon emission computed tomography in the prediction of cardiac death and all-cause mortality: superiority over 85% of maximal age-predicted heart rate. J Am Coll Cardiol 44(2):423\u2013430","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"3524_CR30","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1088\/0967-3334\/28\/10\/006","volume":"28","author":"A Crisafulli","year":"2007","unstructured":"Crisafulli A, Piras F, Chiappori P et al (2007) Estimating stroke volume from oxygen pulse during exercise. Physiol Meas 28(10):1201\u20131212","journal-title":"Physiol Meas"},{"key":"3524_CR31","unstructured":"Sietsema KE, Sue DY, Stringer WW, S.A. W. Wasserman and Whipps Principals of Exercise Testing and Interpretation. 6th ed: Wolters Kluwer 2021."},{"issue":"19","key":"3524_CR32","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1161\/CIRCULATIONAHA.110.958025","volume":"122","author":"J Rhodes","year":"2010","unstructured":"Rhodes J, Ubeda Tikkanen A, Jenkins KJ (2010) Exercise testing and training in children with congenital heart disease. Circulation 122(19):1957\u20131967","journal-title":"Circulation"},{"issue":"2","key":"3524_CR33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/archdischild-2017-314733","volume":"104","author":"J Hock","year":"2019","unstructured":"Hock J, Hacker AL, Reiner B et al (2019) Functional outcome in contemporary children and young adults with tetralogy of Fallot after repair. Arch Dis Child 104(2):129\u2013133","journal-title":"Arch Dis Child"},{"key":"3524_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9010026","author":"B Leonardi","year":"2022","unstructured":"Leonardi B, Gentili F, Perrone MA et al (2022) Cardiopulmonary exercise testing in repaired tetralogy of Fallot: multiparametric overview and correlation with cardiac magnetic resonance and physical activity level. J Cardiovasc Dev Dis. https:\/\/doi.org\/10.3390\/jcdd9010026","journal-title":"J Cardiovasc Dev Dis"},{"issue":"4","key":"3524_CR35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00246-021-02551-y","volume":"42","author":"M Zaqout","year":"2021","unstructured":"Zaqout M, Vandekerckhove K, De Wolf D et al (2021) Determinants of physical fitness in children with repaired congenital heart disease. Pediatr Cardiol 42(4):857\u2013865","journal-title":"Pediatr Cardiol"},{"key":"3524_CR36","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/CIRCULATIONAHA.111.078873","volume":"25","author":"J Rhodes","year":"2012","unstructured":"Rhodes J (2012) Cardiopulmonary exercise testing in adults with congenital heart disease. Circulation 25:210\u2013211","journal-title":"Circulation"},{"key":"3524_CR37","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201612-997FR","author":"A Mezzani","year":"2017","unstructured":"Mezzani A (2017) Cardiopulmonary exercise testing: basics of methodology and measurements. Ann Am Thorac Soc. https:\/\/doi.org\/10.1513\/AnnalsATS.201612-997FR","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"3524_CR38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bjae.2019.01.009","volume":"19","author":"DJ Chambers","year":"2019","unstructured":"Chambers DJ, Wisely NA (2019) Cardiopulmonary exercise testing-a beginner\u2019s guide to the nine-panel plot. BJA Educ 19(5):158\u2013164","journal-title":"BJA Educ"},{"issue":"6","key":"3524_CR39","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0735-1097(96)00412-3","volume":"28","author":"R Baba","year":"1996","unstructured":"Baba R, Nagashima M, Goto M et al (1996) Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise. J Am Coll Cardiol 28(6):1567\u20131572","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"3524_CR40","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/eurheartj\/ehi672","volume":"27","author":"LC Davies","year":"2006","unstructured":"Davies LC, Wensel R, Georgiadou P et al (2006) Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope. Eur Heart J 27(6):684\u2013690","journal-title":"Eur Heart J"},{"issue":"8","key":"3524_CR41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1177\/2047487315611769","volume":"23","author":"BC Bongers","year":"2016","unstructured":"Bongers BC, Hulzebos EH, Helbing WA, Ten Harkel A, van Brussel M, Takken T (2016) Response profiles of oxygen uptake efficiency during exercise in healthy children. Eur J Prev Cardiol 23(8):865\u2013873","journal-title":"Eur J Prev Cardiol"},{"issue":"6","key":"3524_CR42","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/chd.12661","volume":"13","author":"KM Shafer","year":"2018","unstructured":"Shafer KM, Opotowsky AR, Rhodes J (2018) Exercise testing and spirometry as predictors of mortality in congenital heart disease: contrasting fontan physiology with repaired tetralogy of Fallot. Congenit Heart Dis 13(6):903\u2013910","journal-title":"Congenit Heart Dis"},{"issue":"2","key":"3524_CR43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0735-1097(10)80116-0","volume":"17","author":"SA Rowe","year":"1991","unstructured":"Rowe SA, Zahka KG, Manolio TA, Horneffer PJ, Kidd L (1991) Lung function and pulmonary regurgitation limit exercise capacity in postoperative tetralogy of Fallot. J Am Coll Cardiol 17(2):461\u2013466","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"3524_CR44","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/01.CIR.64.6.1234","volume":"64","author":"M Rabinovitch","year":"1981","unstructured":"Rabinovitch M, Herrera-Delon V, Castaneda AR, Reid L (1981) Growth and development of the pulmonary vascular bed in patients with tetralogy of Fallot with or without pulmonary atresia. Circulation 64(6):1234\u20131249","journal-title":"Circulation"},{"issue":"2","key":"3524_CR45","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/ppul.24576","volume":"55","author":"JC Silva","year":"2020","unstructured":"Silva JC, Carvalho IE, Dal Corso S, Lanza FC (2020) Reference equation for maximal voluntary ventilation in children and adolescents. Pediatr Pulmonol 55(2):426\u2013432","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"3524_CR46","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11897-013-0183-3","volume":"11","author":"M Guazzi","year":"2014","unstructured":"Guazzi M (2014) Abnormalities in cardiopulmonary exercise testing ventilatory parameters in heart failure: pathophysiology and clinical usefulness. Curr Heart Fail Rep 11(1):80\u201387","journal-title":"Curr Heart Fail Rep"},{"issue":"1","key":"3524_CR47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00246-018-1962-0","volume":"40","author":"SM Bhatt","year":"2019","unstructured":"Bhatt SM, Elci OU, Wang Y et al (2019) Determinants of exercise performance in children and adolescents with repaired tetralogy of Fallot using stress echocardiography. Pediatr Cardiol 40(1):71\u201378","journal-title":"Pediatr Cardiol"},{"key":"3524_CR48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s002469900393","volume":"20","author":"HU Wessel","year":"1999","unstructured":"Wessel HU, Paul MH (1999) Exercise studies in tetralogy of Fallot: a review. Pediatr Cardiol 20:39\u201347","journal-title":"Pediatr Cardiol"},{"issue":"9","key":"3524_CR49","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.amjcard.2007.06.038","volume":"100","author":"J Meadows","year":"2007","unstructured":"Meadows J, Powell AJ, Geva T, Dorfman A, Gauvreau K, Rhodes J (2007) Cardiac magnetic resonance imaging correlates of exercise capacity in patients with surgically repaired tetralogy of Fallot. Am J Cardiol 100(9):1446\u20131450","journal-title":"Am J Cardiol"},{"issue":"8","key":"3524_CR50","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/ehjci\/jez245","volume":"21","author":"I Rashid","year":"2020","unstructured":"Rashid I, Mahmood A, Ismail TF et al (2020) Right ventricular systolic dysfunction but not dilatation correlates with prognostically significant reductions in exercise capacity in repaired tetralogy of Fallot. Eur Heart J Cardiovasc Imaging 21(8):906\u2013913","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"4","key":"3524_CR51","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ahj.2012.06.029","volume":"165","author":"MK Friedberg","year":"2013","unstructured":"Friedberg MK, Fernandes FP, Roche SL et al (2013) Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair. Am Heart J 165(4):551\u2013557","journal-title":"Am Heart J"},{"key":"3524_CR52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.amjcard.2011.02.349","volume":"108","author":"AK Kipps","year":"2011","unstructured":"Kipps AK, Graham DA, Harrild DM, Lewis E, Powell AJ, Rhodes J (2011) Longitudinal exercise capacity of patients with repaired tetralogy of Fallot. Am J Cardiol 108:99\u2013105","journal-title":"Am J Cardiol"},{"issue":"10","key":"3524_CR53","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/2047487315623405","volume":"23","author":"YJ Tsai","year":"2016","unstructured":"Tsai YJ, Li MH, Tsai WJ, Tuan SH, Liao TY, Lin KL (2016) Oxygen uptake efficiency slope and peak oxygen consumption predict prognosis in children with tetralogy of Fallot. Eur J Prev Cardiol 23(10):1045\u20131050","journal-title":"Eur J Prev Cardiol"},{"issue":"21","key":"3524_CR54","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.jacc.2023.02.052","volume":"81","author":"JP Bokma","year":"2023","unstructured":"Bokma JP, Geva T, Sleeper LA et al (2023) Improved outcomes after pulmonary valve replacement in repaired tetralogy of Fallot. J Am Coll Cardiol 81(21):2075\u20132085","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"3524_CR55","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00246-017-1656-z","volume":"38","author":"F Dallaire","year":"2017","unstructured":"Dallaire F, Wald RM, Marelli A (2017) The role of cardiopulmonary exercise testing for decision making in patients with repaired tetralogy of Fallot. Pediatr Cardiol 38(6):1097\u20131105","journal-title":"Pediatr Cardiol"},{"key":"3524_CR56","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/euhj.1999.1863","volume":"21","author":"DP Francis","year":"2000","unstructured":"Francis DP, Shamim W, Davies LC et al (2000) Cardiopulmonary exercise testing for prognosis in chronic heart failure: contineous and independent prognostic value from VE\/VCO2 slope and peak VO2. Eur Heart J 21:154\u2013161","journal-title":"Eur Heart J"},{"issue":"24","key":"3524_CR57","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1161\/01.CIR.0000041428.99427.06","volume":"106","author":"AK Gitt","year":"2002","unstructured":"Gitt AK, Wasserman K, Kilkowski C et al (2002) Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death. Circulation 106(24):3079\u20133084","journal-title":"Circulation"},{"issue":"10","key":"3524_CR58","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.amjcard.2006.12.076","volume":"99","author":"A Giardini","year":"2007","unstructured":"Giardini A, Specchia S, Tacy TA et al (2007) Usefulness of cardiopulmonary exercise to predict long-term prognosis in adults with repaired tetralogy of Fallot. Am J Cardiol 99(10):1462\u20131467","journal-title":"Am J Cardiol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-024-03524-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-024-03524-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-024-03524-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T15:32:20Z","timestamp":1741793540000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-024-03524-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3524"],"URL":"https:\/\/doi.org\/10.1007\/s00246-024-03524-7","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,28]]},"assertion":[{"value":"2 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No professional relationships exist between authors and companies or manufactures of equipment used in the study. The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}