{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:37:01Z","timestamp":1781563021710,"version":"3.54.5"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>There are a growing number of adult patients palliated to a Fontan circulation. As these patients age, many develop symptomatic heart failure (d\u2019Udekem et al in Circulation 130:S32\u2013S38, 2014) that is exacerbated by acquired comorbidities such as obesity and hypertension. Increased body mass index (BMI) and adiposity have been associated with worse hemodynamics and clinical outcomes in these patients (Yogeswaran et al in J Am Hear Assoc: Cardiovasc Cerebrovasc Dis 12:e026732, 2023). Recently, glucagon-like peptide-1 (GLP-1) agonists, originally developed to treat diabetes mellitus, received FDA approval for weight loss and have been shown to reduce the risk of cardiovascular events in the general population (Vilsb\u00f8ll et al in BMJ 344:d7771, 2012). There are limited data on these medications in patients with a Fontan circulation. We conducted a retrospective review of adults with Fontan circulation followed in our adult congenital heart disease (ACHD) clinic between 2009 and 2023 and identified 8 patients prescribed GLP-1 agonists. We found that GLP-1 agonists were well-tolerated and led to modest reduction in weight and blood pressure. Further study of the use of these medications in this population is warranted.<\/jats:p>","DOI":"10.1007\/s00246-024-03700-9","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T03:49:40Z","timestamp":1731383380000},"page":"2137-2139","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and Efficacy of GLP-1 Agonists in a Cohort of Patients with Fontan Circulation"],"prefix":"10.1007","volume":"46","author":[{"given":"Andrew M.","family":"Freddo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humera","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"Edelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Ortega-Legaspi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Vaikunth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"3700_CR1","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1161\/CIRCULATIONAHA.113.007764","volume":"130","author":"Y d\u2019Udekem","year":"2014","unstructured":"d\u2019Udekem Y, Iyengar AJ, Galati JC et al (2014) Redefining expectations of long-term survival after the Fontan procedure. Circulation 130:S32\u2013S38","journal-title":"Circulation"},{"key":"3700_CR2","doi-asserted-by":"publisher","first-page":"e026732","DOI":"10.1161\/JAHA.122.026732","volume":"12","author":"V Yogeswaran","year":"2023","unstructured":"Yogeswaran V, Anigwe C, Salahuddin A et al (2023) Association of body mass index with clinical features and outcomes in adults with Fontan palliation. J Am Hear Assoc: Cardiovasc Cerebrovasc Dis 12:e026732","journal-title":"J Am Hear Assoc: Cardiovasc Cerebrovasc Dis"},{"key":"3700_CR3","doi-asserted-by":"publisher","first-page":"d7771","DOI":"10.1136\/bmj.d7771","volume":"344","author":"T Vilsb\u00f8ll","year":"2012","unstructured":"Vilsb\u00f8ll T, Christensen M, Junker AE, Knop FK, Gluud LL (2012) Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 344:d7771","journal-title":"BMJ"},{"key":"3700_CR4","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s12325-022-02394-w","volume":"40","author":"PW Moore","year":"2023","unstructured":"Moore PW, Malone K, VanValkenburg D et al (2023) GLP-1 agonists for weight loss: pharmacology and clinical implications. Adv Ther 40:723\u2013742","journal-title":"Adv Ther"},{"key":"3700_CR5","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s10741-019-09904-z","volume":"25","author":"SS Vaikunth","year":"2020","unstructured":"Vaikunth SS, Lui GK (2020) Heart failure with reduced and preserved ejection fraction in adult congenital heart disease. Hear Fail Rev 25:569\u2013581","journal-title":"Hear Fail Rev"},{"key":"3700_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-024-03663-x","author":"EV Shea","year":"2024","unstructured":"Shea EV, Yu S, Schumacher KR et al (2024) Insulin resistance after Fontan palliation. Pediatr Cardiol. https:\/\/doi.org\/10.1007\/s00246-024-03663-x","journal-title":"Pediatr Cardiol"},{"key":"3700_CR7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jacc.2024.04.038","volume":"84","author":"M Schou","year":"2024","unstructured":"Schou M, Petrie MC, Borlaug BA et al (2024) Semaglutide and NYHA functional class in obesity-related heart failure with preserved ejection fraction the STEP-HFpEF program. J Am Coll Cardiol 84:247\u2013257","journal-title":"J Am Coll Cardiol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-024-03700-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-024-03700-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-024-03700-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:25:49Z","timestamp":1759562749000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-024-03700-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["3700"],"URL":"https:\/\/doi.org\/10.1007\/s00246-024-03700-9","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"5 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}