{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T20:13:42Z","timestamp":1786392822257,"version":"build-2736575974"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Klinikum der Universit\u00e4t M\u00fcnchen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The EDUCATE study investigated the acute impact of energy drink (ED) consumption on heart rate variability (HRV) in children and adolescents, with a focus on how these stimulant-rich beverages influence cardiac autonomic function. Given the popularity of EDs among young people, this study assessed the immediate cardiovascular response to ED intake. This randomized, double-blind, placebo-controlled crossover trial involved 26 healthy participants aged 10\u201318 years. Each participant consumed a weight-adjusted ED or placebo in two separate test sessions. HRV was monitored via a 24-h Holter ECG, with analysis centered on time-domain measures, such as the standard deviation of normal RR intervals (SDNN) and root-mean square of successive differences (RMSSD), along with frequency-domain metrics. Statistical analysis included a two-way repeated-measures ANOVA to examine the effects of \u201cbeverage\u201d and \u201ctime.\u201d The study revealed a significant increase in the SDNN in the ED group within the first hour post-consumption, with a mean difference of 17.692 ms compared with that in the placebo group (SDNN: ED\u2009=\u2009133.346\u2009\u00b1\u200950.217\u00a0ms vs. placebo\u2009=\u2009115.654\u2009\u00b1\u200947.583\u00a0ms,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). However, no significant differences in the SDNN were observed in the subsequent time intervals (60\u2013240\u00a0min). In addition, frequency-domain parameters, such as total power, RMSSD, LF, HF, and the LF\/HF ratio, showed no significant changes across the four-hour observation period, indicating that sympathetic activation was transient. The findings suggest that ED consumption in children and adolescents leads to a temporary increase in autonomic activity, marked by elevated SDNN, without lasting dysregulation. While the cardiovascular effects are brief, acute sympathetic activation underscores the need for regulated ED intake among minors. Further studies are recommended to explore the long-term effects of regular ED consumption on cardiovascular health in youth.\n                  <\/jats:p>","DOI":"10.1007\/s00246-025-03770-3","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:45:19Z","timestamp":1737459919000},"page":"332-341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Acute Energy Drink Consumption on Heart Rate Variability in Children and Adolescents. A Randomized Trial"],"prefix":"10.1007","volume":"47","author":[{"given":"Guido","family":"Mandilaras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dalla-Pozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus Alexander","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix Sebastian","family":"Oberhoffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"3770_CR1","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.3390\/nu15112537","volume":"15","author":"P Li","year":"2023","unstructured":"Li P, Haas NA, Dalla-Pozza R, Jakob A, Oberhoffer FS, Mandilaras G (2023) Energy drinks and adverse health events in children and adolescents: a literature review. 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