{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:14:00Z","timestamp":1793934840560,"version":"4.8.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00246-025-03780-1","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:55:51Z","timestamp":1737615351000},"page":"388-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular Performance in Neonates with Hypoxic-Ischemic Encephalopathy Under Therapeutic Hypothermia: Evaluation by Conventional and Advanced Echocardiographic Techniques"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-5525","authenticated-orcid":false,"given":"Vanessa A. C.","family":"Nunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Assef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C. S.","family":"Le Bihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B. M.","family":"Barretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone R. F. F.","family":"Pedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"3780_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2223\/JPED.220","volume":"77","author":"RS Procianoy","year":"2001","unstructured":"Procianoy RS, Silveira RDC (2001) S\u00edndrome hip\u00f3xico-isqu\u00eamica. J Pediatr 77:63\u201370","journal-title":"J Pediatr"},{"key":"3780_CR2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/pr.2013.206","volume":"74","author":"ACC Lee","year":"2013","unstructured":"Lee ACC, Kozuki N, Blencowe H et al (2013) Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. Pediatr Res 74:50\u201372","journal-title":"Pediatr Res"},{"key":"3780_CR3","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran S, Laptook AR, Eherenkranz RA et al (2005) Whole-body hypothermia for neonates with hypoxic\u2013ischemic encephalopathy. N Engl J Med 353:1574\u20131584","journal-title":"N Engl J Med"},{"issue":"2","key":"3780_CR4","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1056\/NEJMoa1315788","volume":"371","author":"D Azzopardi","year":"2014","unstructured":"Azzopardi D, Strohm B, Marlow N et al (2014) Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med 371(2):140\u2013149","journal-title":"N Engl J Med"},{"key":"3780_CR5","first-page":"1","volume":"20","author":"T Wood","year":"2014","unstructured":"Wood T, Thoresen M (2014) Physiological responses to hypothermia. Semin Fetal Neonatal Med 20:1\u201310","journal-title":"Semin Fetal Neonatal Med"},{"key":"3780_CR6","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.echo.2010.03.019","volume":"23","author":"L Lopez","year":"2010","unstructured":"Lopez L, Colan SD, Frommelt PC et al (2010) Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the pediatric measurements writing group of the american society of echocardiography pediatric and congenital heart disease council. J Am Soc Echocardiogr 23:465\u2013495","journal-title":"J Am Soc Echocardiogr"},{"key":"3780_CR7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.earlhumdev.2013.08.019","volume":"89","author":"LM Klitsie","year":"2013","unstructured":"Klitsie LM, Roest AAW, Haak MC et al (2013) Longitudinal follow-up of ventricular performance in healthy neonates. Early Hum Dev 89:993\u2013997","journal-title":"Early Hum Dev"},{"issue":"10","key":"3780_CR8","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","volume":"33","author":"HB Sarnat","year":"1976","unstructured":"Sarnat HB, Sarnat MS (1976) Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Archiv Neurol 33(10):696\u2013705","journal-title":"Archiv Neurol"},{"issue":"7","key":"3780_CR9","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1111\/j.1651-2227.1997.tb08581.x","volume":"86","author":"CM Thompson","year":"1997","unstructured":"Thompson CM, Puterman AS, Linley LL et al (1997) The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr 86(7):757\u2013761","journal-title":"Acta Paediatr"},{"issue":"6","key":"3780_CR10","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1002\/ar.24615","volume":"304","author":"AN Kinoshita","year":"2021","unstructured":"Kinoshita AN, Magalh\u00e3es M, Rodrigues DP et al (2021) Effectiveness of reaching and maintaining therapeutic hypothermia target temperature using low-cost devices in newborns with hypoxic\u2013ischemic encephalopathy. Anat Rec 304(6):1217\u20131223","journal-title":"Anat Rec"},{"key":"3780_CR11","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1590\/1516-3180.2013.7740026","volume":"133","author":"M Magalh\u00e3es","year":"2015","unstructured":"Magalh\u00e3es M, Rodrigues FPM, Chopard MRT et al (2015) Neuroprotective body hypothermia among newborns with hypoxic ischemic encephalopathy: three-year experience in a tertiary university hospital A retrospective observational study. Sao Paulo Med J 133:314\u2013319","journal-title":"Sao Paulo Med J"},{"key":"3780_CR12","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/S0003-4975(99)00441-5","volume":"67","author":"JN McCullough","year":"1999","unstructured":"McCullough JN, Zhang N, Reich DL et al (1999) Cerebral metabolic suppression during hypothermic circulatory arrest in humans. Ann Thorac Surg 67:1895\u20131899","journal-title":"Ann Thorac Surg"},{"key":"3780_CR13","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1111\/apa.13866","volume":"106","author":"S Aggarwal","year":"2017","unstructured":"Aggarwal S, Natarajan G (2017) Biventricular Function on early echocardiograms in neonatal hypoxic\u2013ischaemic encephalopathy. Acta Paediatr 106:1085\u20131090","journal-title":"Acta Paediatr"},{"key":"3780_CR14","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.jpeds.2014.01.028","volume":"164","author":"O Hochwald","year":"2014","unstructured":"Hochwald O, Jabr M, Osiovich H et al (2014) Preferential cephalic redistribution of left ventricular cardiac output during therapeutic hypothermia for perinatal hypoxic-ischemic encephalopathy. J Pediatr 164:999\u20131004","journal-title":"J Pediatr"},{"key":"3780_CR15","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.ultrasmedbio.2013.03.024","volume":"39","author":"C Czernik","year":"2013","unstructured":"Czernik C, Rhode S, Helfer S et al (2013) Left ventricular longitudinal strain and strain rate measured by 2-D speckle tracking echocardiography in neonates during whole-body hypothermia. Ultrasound Med Biol 39:1343\u20131349","journal-title":"Ultrasound Med Biol"},{"key":"3780_CR16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1476-7120-11-34","volume":"11","author":"A Sehgal","year":"2013","unstructured":"Sehgal A, Wong F, Menahem S (2013) Speckle tracking derived strain in infants with severe perinatal asphyxia: a comparative case control study. Cardiovasc Ultrasound 11:34","journal-title":"Cardiovasc Ultrasound"},{"key":"3780_CR17","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.echo.2012.11.017","volume":"26","author":"M Cantinotti","year":"2013","unstructured":"Cantinotti M, Lopez L (2013) Nomograms for blood flow and tissue doppler velocities to evaluate diastolic function in children: a critical review. J Am Soc Echocardiogr 26:126\u2013141","journal-title":"J Am Soc Echocardiogr"},{"key":"3780_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.resuscitation.2016.06.023","volume":"106","author":"M Elstad","year":"2016","unstructured":"Elstad M, Liu X, Thoresen M (2016) Heart rate response to therapeutic hypothermia in infants with hypoxic\u2013ischaemic encephalopathy. Resuscitation 106:53\u201357","journal-title":"Resuscitation"},{"key":"3780_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1012-8","author":"JR Paonessa","year":"2015","unstructured":"Paonessa JR, Brennan T, Pimentel M et al (2015) Hyperdynamic left ventricular ejection fraction in the intensive care unit. Crit Care. https:\/\/doi.org\/10.1186\/s13054-015-1012-8","journal-title":"Crit Care"},{"key":"3780_CR20","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/S0735-1097(85)80498-8","volume":"6","author":"MA Carpenter","year":"1985","unstructured":"Carpenter MA, Dammann JF, Watson DD et al (1985) Left ventricular hyperkinesia at rest and during exercise in normotensive patients 2 to 27 years after coarctation repair. JACC 6:879\u2013886","journal-title":"JACC"},{"key":"3780_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.earlhumdev.2014.01.014","volume":"90","author":"E Nestaas","year":"2014","unstructured":"Nestaas E, Skranes JH, St\u00f8ylen A et al (2014) The myocardial function during and after whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy, a cohort study. Early Hum Dev 90:247\u2013252","journal-title":"Early Hum Dev"},{"key":"3780_CR22","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0033-0620(72)90006-0","volume":"15","author":"WF Friedman","year":"1972","unstructured":"Friedman WF (1972) The intrinsic physiologic properties of the developing heart. Prog Cardiovasc Dis 15:87\u2013111","journal-title":"Prog Cardiovasc Dis"},{"key":"3780_CR23","doi-asserted-by":"publisher","DOI":"10.4172\/2167-0897.1000198","author":"K Kobata","year":"2015","unstructured":"Kobata K, Nabetani M (2015) Experiences of therapeutic hypothermia therapy on six cases with persistent pulmonary hypertension and moderate to severe hypoxic ischemic encephalopathy using inhaled nitric oxide therapy. J Neonatal Biol. https:\/\/doi.org\/10.4172\/2167-0897.1000198","journal-title":"J Neonatal Biol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-03780-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-025-03780-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-03780-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:43:16Z","timestamp":1769064196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-025-03780-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["3780"],"URL":"https:\/\/doi.org\/10.1007\/s00246-025-03780-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4714069\/v1","asserted-by":"object"}]},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"assertion":[{"value":"9 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national guidelines on human experimentation in Brazil and with the Helsinki Declaration of 1975, as revised in 2008, and have been approved by the regional committees for medical and health research, Brazil.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}