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The study aims to assess the impact of high-burden idiopathic PVCs on children in comparison with adults in terms of symptoms, distribution of origin, management strategies, and safety considerations. This is a single-center retrospective cohort study that included patients with frequent PVCs (&gt;\u200910% burden in Holter monitoring) and categorized by age into adult group (\u2265\u200918\u00a0years) and pediatric group. Data encompassed demographic profiles, clinical symptoms, echocardiographic findings, electrocardiographic analyses, and one-year follow-up management. A total of 224 PVC cases were collected during a 2-year study (120 children and 104 adults). Syncope occurred significantly more in children than adults (15.8% vs. 0.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). In children, the right ventricular outflow tract (RVOT) free wall was the predominant site (48 patients; 40%), while the septal RVOT was most common in adults (35 patients; 33.7%). Pediatric cases exhibited significantly higher PVCs originating from the outflow tract (92.5% vs. 69.2%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Nevertheless, there were no significant differences between groups regarding the safety, acute, and one-year outcomes of RF ablation. Age disparities were evident in syncope incidence and PVC origin, with no variance in PVC-induced myopathy prevalence or the safety and outcomes of RF catheter ablation between children and adults.\n                  <\/jats:p>","DOI":"10.1007\/s00246-025-03784-x","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T01:52:36Z","timestamp":1738461156000},"page":"435-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of High Burden Idiopathic Premature Ventricular Contractions in Pediatric versus Adult Populations. A Retrospective Cohort Study"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-9196","authenticated-orcid":false,"given":"Lamyaa Elsayed","family":"Allam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervat Aboulmaaty","family":"Nabih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5141-2376","authenticated-orcid":false,"given":"Mohamed Basyouni","family":"Helal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4345-2096","authenticated-orcid":false,"given":"Abdallah R.","family":"Allam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Nabil","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,2]]},"reference":[{"issue":"10","key":"3784_CR1","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.3390\/diagnostics11101840","volume":"11","author":"D Muser","year":"2021","unstructured":"Muser D, Tritto M, Mariani MV, Di Monaco A, Compagnucci P, Accogli M, De Ponti R, Guarracini F (2021) Diagnosis and treatment of idiopathic premature ventricular contractions: a stepwise approach based on the site of origin. 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