{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:22:15Z","timestamp":1780964535518,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bioelectrical impedance analysis (BIA) is a noninvasive tool that can estimate volume status using fluid compartment ratios. Previous studies have demonstrated that BIA can be used to help manage heart failure using the edema index (EI), which is the ratio of extracellular water (ECW) to total body water (TBW). This study set out to better define the relationship between BIA fluid compartment estimations and invasive hemodynamic measurements, in the context of pediatric and congenital heart disease. 52 individuals underwent 59 elective catheterizations and BIA. Data from the BIAs were compared with the hemodynamic catheterization data. The median age at the time of catheterization was 16.6 [13.5, 19.6] years (63%\u2009&lt;\u200918\u00a0years-old), and 29% were female. In multivariable analysis, EI (\u03b2\u2009=\u2009103.5\u2009\u00b1\u200947.9, p\u2009=\u20090.04), body mass index (BMI) (\u03b2\u2009=\u20090.16\u2009\u00b1\u20090.07, p\u2009=\u20090.02), and current Fontan circulation (\u03b2\u2009=\u20093.06\u2009\u00b1\u20090.96, p\u2009=\u20090.002) were statistically significant predictors of pulmonary capillary wedge pressure (PCWP). Individuals with an EI\u2009\u2265\u20090.39 had a statistically significant higher PCWP compared to those with an EI\u2009&lt;\u20090.39 (12 [11, 17] vs. 10 [8, 12],\u2009=\u20090.05), with an area under the curve (AUC) of 0.76 (95% CI 0.65, 0.87). There was no statistically significant mean difference between the pre-catheterization and either post-catheterization EI (\u2212\u00a00.0001 mean difference (0% change), p\u2009=\u20090.92), or body fat mass (BFM) (+\u20090.035 mean difference (0.2% change), p\u2009=\u20090.81). This study suggests that BIA, and more specifically EI, can noninvasively provide valuable information about hemodynamic data. BIA provides a quick, easy, non-invasive method for assessing and managing the volume status in individuals with congenital heart disease.<\/jats:p>","DOI":"10.1007\/s00246-025-03840-6","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T01:35:50Z","timestamp":1743730550000},"page":"777-783","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioelectrical Impedance Analysis and How it Correlates to Intracardiac Hemodynamics in Patients with Congenital Heart Disease"],"prefix":"10.1007","volume":"47","author":[{"given":"David A.","family":"Katz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarosh P.","family":"Batlivala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Opotowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam W.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"3840_CR1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.5603\/ait.2014.0060","volume":"46","author":"ML Malbrain","year":"2014","unstructured":"Malbrain ML, Marik PE, Witters I, Cordemans C, Kirkpatrick AW, Roberts DJ, Van Regenmortel N (2014) Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice. Anaesthesiol Intensive Ther 46:361\u2013380. https:\/\/doi.org\/10.5603\/ait.2014.0060","journal-title":"Anaesthesiol Intensive Ther"},{"key":"3840_CR2","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/jpen.1994","volume":"45","author":"RT Hurt","year":"2021","unstructured":"Hurt RT, Ebbert JO, Croghan I, Nanda S, Schroeder DR, Teigen LM, Velapati SR, Mundi MS (2021) The comparison of segmental multifrequency bioelectrical impedance analysis and dual-Energy X-ray absorptiometry for estimating fat free mass and percentage body fat in an ambulatory population. JPEN J Parenter Enteral Nutr 45:1231\u20131238. https:\/\/doi.org\/10.1002\/jpen.1994","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"3840_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/089686080402400305","volume":"24","author":"RB Asghar","year":"2004","unstructured":"Asghar RB, Green S, Engel B, Davies SJ (2004) Relationship of demographic, dietary, and clinical factors to the hydration status of patients on peritoneal dialysis. Perit Dial Int 24:231\u2013239","journal-title":"Perit Dial Int"},{"key":"3840_CR4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/ki.2014.207","volume":"86","author":"SJ Davies","year":"2014","unstructured":"Davies SJ, Davenport A (2014) The role of bioimpedance and biomarkers in helping to aid clinical decision-making of volume assessments in dialysis patients. Kidney Int 86:489\u2013496. https:\/\/doi.org\/10.1038\/ki.2014.207","journal-title":"Kidney Int"},{"key":"3840_CR5","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2023.38.e276","volume":"38","author":"KS Lee","year":"2023","unstructured":"Lee KS, Kim JH, Kang J, Cho HJ, Lee HY (2023) association between changes in bioelectrical impedance analysis (BIA) parameter and the clinical outcomes in patients with acute heart failure. J Korean Med Sci 38:e276. https:\/\/doi.org\/10.3346\/jkms.2023.38.e276","journal-title":"J Korean Med Sci"},{"key":"3840_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/hpc.0000000000000105","volume":"16","author":"KJ Lyons","year":"2017","unstructured":"Lyons KJ, Bischoff MK, Fonarow GC, Horwich TB (2017) Noninvasive bioelectrical impedance for predicting clinical outcomes in outpatients with heart failure. Crit Pathw Cardiol 16:32\u201336. https:\/\/doi.org\/10.1097\/hpc.0000000000000105","journal-title":"Crit Pathw Cardiol"},{"key":"3840_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1536\/ihj.53.11","volume":"53","author":"M-H Liu","year":"2012","unstructured":"Liu M-H, Wang C-H, Huang Y-Y, Tung T-H, Lee C-M, Yang N-I, Wang J-S, Kuo L-T, Cherng W-J (2012) Edema index-guided disease management improves 6-month outcomes of patients with acute heart failure. Int Heart J 53:11\u201317. https:\/\/doi.org\/10.1536\/ihj.53.11","journal-title":"Int Heart J"},{"issue":"2","key":"3840_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/chd.12683","volume":"14","author":"M Sato","year":"2019","unstructured":"Sato M, Inai K, Shimizu M, Sugiyama H, Nakanishi T (2019) Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease. Congenit Heart Dis 14(2):167\u2013175. https:\/\/doi.org\/10.1111\/chd.12683","journal-title":"Congenit Heart Dis"},{"key":"3840_CR9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37377","volume":"15","author":"D Hanna","year":"2023","unstructured":"Hanna D, Baig I, Subbiondo R, Iqbal U (2023) The usefulness of bioelectrical impedance as a marker of fluid status in patients with congestive heart failure: a systematic review and meta-analysis. Cureus 15:e37377. https:\/\/doi.org\/10.7759\/cureus.37377","journal-title":"Cureus"},{"key":"3840_CR10","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.chest.2018.05.006","volume":"154","author":"J Weatherald","year":"2018","unstructured":"Weatherald J, Huertas A, Boucly A, Guignabert C, Taniguchi Y, Adir Y, Jevnikar M, Savale L, Jais X, Peng M, Simonneau G, Montani D, Humbert M, Sitbon O (2018) Association between BMI and obesity with survival in pulmonary arterial hypertension. Chest 154:872\u2013881. https:\/\/doi.org\/10.1016\/j.chest.2018.05.006","journal-title":"Chest"},{"issue":"1","key":"3840_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/ejhf.2756","volume":"25","author":"S Caravita","year":"2023","unstructured":"Caravita S, Baratto C (2023) Understanding mechanisms of fontan failure: exercise haemodynamics to unmask diastolic dysfunction, again! Eur J Heart Fail 25(1):26\u201329. https:\/\/doi.org\/10.1002\/ejhf.2756","journal-title":"Eur J Heart Fail"},{"key":"3840_CR12","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1002\/ejfh.2294","volume":"23","author":"S Caravita","year":"2021","unstructured":"Caravita S, Iacovoni A, Senni M (2021) The right side of the circulation is not secondary heart failure with preserved ejection fraction: an elephant in the room? Eur J Heart Fail 23:1659\u20131661. https:\/\/doi.org\/10.1002\/ejfh.2294","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"3840_CR13","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026508","volume":"12","author":"D Peck","year":"2023","unstructured":"Peck D, Averin K, Khoury P, Veldhuis G, Alsaied T, Lubert AM, Hirsch R, Whiteside WM, Veldtman G, Goldstein BH (2023) Occult diastolic dysfunction and adverse clinical outcomes in adolescents and young adults with fontan circulation. J Am Heart Assoc 12(1):e026508. https:\/\/doi.org\/10.1161\/JAHA.122.026508","journal-title":"J Am Heart Assoc"},{"key":"3840_CR14","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/0002-9149(92)90808","volume":"69","author":"DJ Penny","year":"1992","unstructured":"Penny DJ, Redington AN (1992) Diastolic ventricular function after the fontan operation. AM J Cardiol 69:974\u2013975. https:\/\/doi.org\/10.1016\/0002-9149(92)90808","journal-title":"AM J Cardiol"},{"issue":"18","key":"3840_CR15","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1161\/CIRCULATIONAHA.109.854331","volume":"120","author":"US Krishnan","year":"2009","unstructured":"Krishnan US, Taneja I, Gewitz M, Young R, Stewart J (2009) Peripheral vascular adaptation and orthostatic tolerance in fontan physiology. Circulation 120(18):1775\u20131783. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.854331","journal-title":"Circulation"},{"key":"3840_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahjo.2022.100133","volume":"15","author":"M Polcz","year":"2022","unstructured":"Polcz M, Huston J, Breed M, Case M, Leisy P, Schmeckpeper J, Vaughn L, Sobey JH, Brophy C, Lindenfeld J, Hocking K, Alvis B (2022) Comparison of clinical symptoms and bioimpedance to pulmonary capillary wedge pressure in heart failure. Am Heart J Plus 15:100133. https:\/\/doi.org\/10.1016\/j.ahjo.2022.100133","journal-title":"Am Heart J Plus"},{"issue":"4","key":"3840_CR17","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1093\/eurjhf\/hfs023","volume":"14","author":"P Lynga","year":"2012","unstructured":"Lynga P, Persson H, Hagg-Martinell A, Hagglund E, Hagerman I, Langius-Eklof A, Rosenqvist M (2012) Weight monitoring in patients with severe heart failure (WISH). A randomized controlled trial. Eur J Heart Fail 14(4):438\u2013444. https:\/\/doi.org\/10.1093\/eurjhf\/hfs023","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"3840_CR18","first-page":"325","volume":"2","author":"JP Navas","year":"1993","unstructured":"Navas JP, Martinez-Maldonado M (1993) Pathophysiology of edema in congestive heart failure. Heart Dis Stroke 2(4):325\u2013329","journal-title":"Heart Dis Stroke"},{"issue":"10","key":"3840_CR19","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1001\/jama.1956.02960450040010","volume":"160","author":"M Walser","year":"1956","unstructured":"Walser M, Duffy BJ Jr, Griffith HW (1956) Body fluids in hypertension and mild heart failure. J Am Med Assoc 160(10):858\u2013864. https:\/\/doi.org\/10.1001\/jama.1956.02960450040010","journal-title":"J Am Med Assoc"},{"issue":"2","key":"3840_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1053\/j.akdh.2022.12.002","volume":"30","author":"A Koirala","year":"2023","unstructured":"Koirala A, Pourafshar N, Daneshmand A, Wilcox CS, Mannemuddhu SS, Arora N (2023) Etiology and management of edema: a review. Adv Kidney Dis Health 30(2):110\u2013123. https:\/\/doi.org\/10.1053\/j.akdh.2022.12.002","journal-title":"Adv Kidney Dis Health"},{"issue":"1","key":"3840_CR21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.5334\/gh.1287","volume":"19","author":"BR Sasmita","year":"2024","unstructured":"Sasmita BR, Zhao Y, Gong M, Luo S, Huang B (2024) Edema index predicts mortality in patients with chronic heart failure: a prospective, observational study. Glob Heart 19(1):5. https:\/\/doi.org\/10.5334\/gh.1287","journal-title":"Glob Heart"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-03840-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-025-03840-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-03840-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:09:23Z","timestamp":1769677763000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-025-03840-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["3840"],"URL":"https:\/\/doi.org\/10.1007\/s00246-025-03840-6","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]},"assertion":[{"value":"10 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}