{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:11:44Z","timestamp":1789092704878,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Detailed characterization of myocardial deformation, ventricular shape, outflow tract size, inflow Doppler patterns, cerebroplacental circulation, and cardiac output of fetuses with suspected coarctation of the aorta (COA) and a control group to gain further insights into differences between these groups. Expectant women were prospectively recruited for assessment during the third trimester of pregnancy and a comparison of echocardiographic characteristics and fetoplacental circulation according to postnatal diagnosis of either confirmed COA (c-COA), false-positive COA (fp-COA), and a control population. There were 42 fetuses recruited with suspected COA of whom 20\/42 (48%) had c-COA. Fetuses with c-COA demonstrated lower (less negative) LV global longitudinal strain (LV-GLS) compared to controls (\u2212\u00a020.2%\u2009\u00b1\u20094.3 vs. \u2212\u00a023.1%\u2009\u00b1\u20092.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and a non-significant trend to lower strain in the fp-COA group (LV-GLS: \u2212\u00a020.7%\u2009\u00b1\u20095.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.053) compared to controls. RV-GLS was significantly reduced in the fp-COA group compared to the c-COA and control groups (fp-COA: \u2212\u00a019.8%\u2009\u00b1\u20094.5, c-COA: \u2212\u00a023.1%\u2009\u00b1\u20094.4, control: \u2212\u00a023.5%\u2009\u00b1\u20093.6,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). C-COA and fp-COA had a less spherical (narrower) LV, shorter LV, and a more spherical RV compared to controls. The arterial duct diameter was larger in c-COA compared to fp-COA and controls. When analyzed according to diagnostic group, determinants of GLS and sphericity index differed between groups. For c-COA, there was correlation between LV-GLS and RV-GLS (r\u2009=\u2009\u2212\u00a00.51,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021). Determinants of LV-GLS in fp-COA were distal transverse aortic arch z-score and umbilical artery PI (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037 respectively). The only determinant of RV-GLS in the FP-COA was arterial duct z-score (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2212\u00a00.51,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019). There are measurable differences in functional parameters between c-COA, fp-COA, and controls. The hemodynamic characteristics of c-COA and fp-COA merit further study and should include study of the RV and cerebroplacental evaluation.\n                  <\/jats:p>","DOI":"10.1007\/s00246-025-03878-6","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:20:16Z","timestamp":1746685216000},"page":"1056-1067","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myocardial Deformation and Its Relation to Ventricular Shape, Preload, and Afterload in Fetuses with Suspected Coarctation of the Aorta"],"prefix":"10.1007","volume":"47","author":[{"given":"Trisha V.","family":"Vigneswaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Woodgate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Rato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Razavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"3878_CR1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1136\/hrt.2003.033027","volume":"91","author":"CE Head","year":"2005","unstructured":"Head CE, Jowett VC, Sharland GK, Simpson JM (2005) Timing of presentation and postnatal outcome of infants suspected of having coarctation of the aorta during fetal life. 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