{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:01:41Z","timestamp":1774591301373,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00246-025-03887-5","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T05:03:19Z","timestamp":1746853399000},"page":"919-931","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Pulmonary Vasodilators in Pediatric Patients with Single-Ventricle Palliation: A Ten-Year Experience in a Tertiary Care Center"],"prefix":"10.1007","volume":"47","author":[{"given":"Rita","family":"Blandino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Manuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasqualina","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ragni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Piccinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Pilati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micol","family":"Rebonato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Brancaccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Butera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Santilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Galletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Iacobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"3887_CR1","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/0002-9149(64)90453-9","volume":"13","author":"R Vanpraagh","year":"1964","unstructured":"Vanpraagh R, Ongley PA, Swan HJ (1964) Anatomic types of single or common ventricle in man. Morphologic and geometric aspects of 60 necropsied case. S Am J Cardiol 13:367\u2013386. https:\/\/doi.org\/10.1016\/0002-9149(64)90453-9","journal-title":"S Am J Cardiol"},{"key":"3887_CR2","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1161\/CIRCULATIONAHA.105.592378","volume":"115","author":"P Khairy","year":"2007","unstructured":"Khairy P, Poirier N, Mercier L-A (2007) Univentricular heart. Circulation 115:800\u2013812. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.592378","journal-title":"Circulation"},{"key":"3887_CR3","first-page":"113","volume":"4","author":"R van Praagh","year":"1979","unstructured":"van Praagh R, Plett JA, van Praagh S (1979) Single ventricle. Pathology, embryology, terminology and classification. Herz 4:113\u2013150","journal-title":"Herz"},{"key":"3887_CR4","first-page":"39","volume":"10","author":"F Fontan","year":"1971","unstructured":"Fontan F, Mounicot FB, Baudet E et al (1971) \u201cCorrection\u201d of tricuspid atresia. 2 cases \u201ccorrected\u201d using a new surgical technic. Ann Chir Thorac Cardiovasc 10:39\u201347","journal-title":"Ann Chir Thorac Cardiovasc"},{"key":"3887_CR5","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/S0022-5223(19)35174-8","volume":"96","author":"MR de Leval","year":"1988","unstructured":"de Leval MR, Kilner P, Gewillig M, Bull C (1988) Total cavopulmonary connection: a logical alternative to atriopulmonary connection for complex Fontan operations. Experimental studies and early clinical experience. J Thorac Cardiovasc Surg 96:682\u2013695","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3887_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308378","author":"R Kozlik-Feldmann","year":"2016","unstructured":"Kozlik-Feldmann R, Hansmann G, Bonnet D et al (2016) Pulmonary hypertension in children with congenital heart disease (PAH-CHD, PPHVD-CHD). Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European paediatric pulmonary vascular disease network, endorsed by ISHLT and DGPK. Heart Br Card Soc. https:\/\/doi.org\/10.1136\/heartjnl-2015-308378","journal-title":"Heart Br Card Soc"},{"key":"3887_CR7","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.21037\/tp-23-64","volume":"12","author":"J Wacker","year":"2023","unstructured":"Wacker J, Joye R, Genecand L et al (2023) Pulmonary vascular disease as a complication of pediatric congenital heart diseases. Transl Pediatr 12:1041\u20131052. https:\/\/doi.org\/10.21037\/tp-23-64","journal-title":"Transl Pediatr"},{"key":"3887_CR8","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1161\/CIRCULATIONAHA.114.006974","volume":"130","author":"M Humbert","year":"2014","unstructured":"Humbert M, Lau EMT, Montani D et al (2014) Advances in therapeutic interventions for patients with pulmonary arterial hypertension. Circulation 130:2189\u20132208. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.006974","journal-title":"Circulation"},{"key":"3887_CR9","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1136\/hrt.2010.193912","volume":"96","author":"M Beghetti","year":"2010","unstructured":"Beghetti M (2010) Fontan and the pulmonary circulation: a potential role for new pulmonary hypertension therapies. Heart Br Card Soc 96:911\u2013916. https:\/\/doi.org\/10.1136\/hrt.2010.193912","journal-title":"Heart Br Card Soc"},{"key":"3887_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12314","author":"B Castaldi","year":"2018","unstructured":"Castaldi B, Bordin G, Padalino M et al (2018) Hemodynamic impact of pulmonary vasodilators on single ventricle physiology. Cardiovasc Ther. https:\/\/doi.org\/10.1111\/1755-5922.12314","journal-title":"Cardiovasc Ther"},{"key":"3887_CR11","doi-asserted-by":"publisher","first-page":"552","DOI":"10.2459\/JCM.0b013e328361390a","volume":"16","author":"R Giordano","year":"2015","unstructured":"Giordano R, Palma G, Poli V et al (2015) First experience with sildenafil after Fontan operation: short-term outcomes. J Cardiovasc Med Hagerstown Md 16:552\u2013555. https:\/\/doi.org\/10.2459\/JCM.0b013e328361390a","journal-title":"J Cardiovasc Med Hagerstown Md"},{"key":"3887_CR12","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1017\/S1047951119001513","volume":"29","author":"AD Molfetta","year":"2019","unstructured":"Molfetta AD, Iacobelli R, Rotella S et al (2019) Predicting the pressure of the total cavopulmonary connection: clinical testing of a mathematical equation. Cardiol Young 29:1066\u20131071. https:\/\/doi.org\/10.1017\/S1047951119001513","journal-title":"Cardiol Young"},{"key":"3887_CR13","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1097\/PCC.0b013e3181d10cce","volume":"11","author":"TM Giglia","year":"2010","unstructured":"Giglia TM, Humpl T (2010) Preoperative pulmonary hemodynamics and assessment of operability: Is there a pulmonary vascular resistance that precludes cardiac operation? Pediatr Crit Care Med 11:S57. https:\/\/doi.org\/10.1097\/PCC.0b013e3181d10cce","journal-title":"Pediatr Crit Care Med"},{"key":"3887_CR14","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s00246-010-9811-9","volume":"31","author":"HJ Stern","year":"2010","unstructured":"Stern HJ (2010) Fontan \u201cten commandments\u201d revisited and revised. Pediatr Cardiol 31:1131\u20131134. https:\/\/doi.org\/10.1007\/s00246-010-9811-9","journal-title":"Pediatr Cardiol"},{"key":"3887_CR15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/hc0202.102237","volume":"105","author":"MS Lemler","year":"2002","unstructured":"Lemler MS, Scott WA, Leonard SR et al (2002) Fenestration improves clinical outcome of the Fontan procedure: a prospective, randomized study. Circulation 105:207\u2013212. https:\/\/doi.org\/10.1161\/hc0202.102237","journal-title":"Circulation"},{"key":"3887_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.recesp.2012.05.010","volume":"66","author":"AM Naranjo-Ugalde","year":"2013","unstructured":"Naranjo-Ugalde AM, Rivera-Ladino KM, Consuegra-Chuarey MT et al (2013) Sildenafil before total cavopulmonary connection. Rev Espanola Cardiol Engl Ed 66:71. https:\/\/doi.org\/10.1016\/j.recesp.2012.05.010","journal-title":"Rev Espanola Cardiol Engl Ed"},{"key":"3887_CR17","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1093\/bja\/aei027","volume":"94","author":"DC T\u00f6rnberg","year":"2005","unstructured":"T\u00f6rnberg DC, Angdin M, Settergen G et al (2005) Exhaled nitric oxide before and after cardiac surgery with cardiopulmonary bypass\u2013response to acetylcholine and nitroglycerin. Br J Anaesth 94:174\u2013180. https:\/\/doi.org\/10.1093\/bja\/aei027","journal-title":"Br J Anaesth"},{"key":"3887_CR18","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1067\/mtc.2003.193","volume":"125","author":"M L\u00e9vy","year":"2003","unstructured":"L\u00e9vy M, Danel C, Laval A-M et al (2003) Nitric oxide synthase expression by pulmonary arteries: a predictive marker of Fontan procedure outcome? J Thorac Cardiovasc Surg 125:1083\u20131090. https:\/\/doi.org\/10.1067\/mtc.2003.193","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3887_CR19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0003-4975(99)00374-4","volume":"68","author":"T Hiramatsu","year":"1999","unstructured":"Hiramatsu T, Imai Y, Takanashi Y et al (1999) Time course of endothelin-1 and adrenomedullin after the Fontan procedure. Ann Thorac Surg 68:169\u2013172. https:\/\/doi.org\/10.1016\/s0003-4975(99)00374-4","journal-title":"Ann Thorac Surg"},{"key":"3887_CR20","doi-asserted-by":"publisher","first-page":"254","DOI":"10.4103\/apc.apc_76_23","volume":"16","author":"D Fakhri","year":"2023","unstructured":"Fakhri D, Busro PW, Rahmat B et al (2023) Retrospective study of preoperative sildenafil in prolonged pleural effusion after Fontan. Ann Pediatr Cardiol 16:254\u2013259. https:\/\/doi.org\/10.4103\/apc.apc_76_23","journal-title":"Ann Pediatr Cardiol"},{"key":"3887_CR21","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1007\/s00246-020-02424-w","volume":"41","author":"I Jeremiasen","year":"2020","unstructured":"Jeremiasen I, Tran-Lundmark K, Idris N et al (2020) Pulmonary vasodilator therapy in children with single ventricle physiology: effects on saturation and pulmonary arterial pressure. Pediatr Cardiol 41:1651\u20131659. https:\/\/doi.org\/10.1007\/s00246-020-02424-w","journal-title":"Pediatr Cardiol"},{"key":"3887_CR22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.94.1.44","volume":"94","author":"AP Goldman","year":"1996","unstructured":"Goldman AP, Delius RE, Deanfield JE et al (1996) Pharmacological control of pulmonary blood flow with inhaled nitric oxide after the fenestrated Fontan operation. Circulation 94:44\u201348","journal-title":"Circulation"},{"key":"3887_CR23","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0022-5223(97)70355-6","volume":"113","author":"A Gamillscheg","year":"1997","unstructured":"Gamillscheg A, Zobel G, Urlesberger B et al (1997) Inhaled nitric oxide in patients with critical pulmonary perfusion after Fontan-type procedures and bidirectional Glenn anastomosis. J Thorac Cardiovasc Surg 113:435\u2013442. https:\/\/doi.org\/10.1016\/S0022-5223(97)70355-6","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3887_CR24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00595-004-2887-1","volume":"35","author":"N Yoshimura","year":"2005","unstructured":"Yoshimura N, Yamaguchi M, Oka S et al (2005) Inhaled nitric oxide therapy after Fontan-type operations. Surg Today 35:31\u201335. https:\/\/doi.org\/10.1007\/s00595-004-2887-1","journal-title":"Surg Today"},{"key":"3887_CR25","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.athoracsur.2008.05.014","volume":"86","author":"J Cai","year":"2008","unstructured":"Cai J, Su Z, Shi Z et al (2008) Nitric oxide and milrinone: combined effect on pulmonary circulation after Fontan-type procedure: a prospective, randomized study. Ann Thorac Surg 86:882\u2013888. https:\/\/doi.org\/10.1016\/j.athoracsur.2008.05.014","journal-title":"Ann Thorac Surg"},{"key":"3887_CR26","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00246-009-9632-x","volume":"31","author":"JY Uhm","year":"2010","unstructured":"Uhm JY, Jhang W-K, Park J-J et al (2010) Postoperative use of oral sildenafil in pediatric patients with congenital heart disease. Pediatr Cardiol 31:515\u2013520. https:\/\/doi.org\/10.1007\/s00246-009-9632-x","journal-title":"Pediatr Cardiol"},{"key":"3887_CR27","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1007\/s00246-017-1716-4","volume":"38","author":"JLG Collins","year":"2017","unstructured":"Collins JLG, Law MA, Borasino S et al (2017) Routine sildenafil does not improve clinical outcomes after Fontan operation. Pediatr Cardiol 38:1703\u20131708. https:\/\/doi.org\/10.1007\/s00246-017-1716-4","journal-title":"Pediatr Cardiol"},{"key":"3887_CR28","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1111\/aas.13431","volume":"63","author":"TK Koski","year":"2019","unstructured":"Koski TK, Suominen PK, Raissadati A et al (2019) The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation. Acta Anaesthesiol Scand 63:1384\u20131389. https:\/\/doi.org\/10.1111\/aas.13431","journal-title":"Acta Anaesthesiol Scand"},{"key":"3887_CR29","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1017\/S1047951114001772","volume":"25","author":"A Mendoza","year":"2015","unstructured":"Mendoza A, Albert L, Belda S et al (2015) Pulmonary vasodilator therapy and early postoperative outcome after modified Fontan operation. Cardiol Young 25:1136\u20131140. https:\/\/doi.org\/10.1017\/S1047951114001772","journal-title":"Cardiol Young"},{"key":"3887_CR30","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.amjcard.2005.03.034","volume":"96","author":"JR Cava","year":"2005","unstructured":"Cava JR, Bevandic SM, Steltzer MM, Tweddell JS (2005) A medical strategy to reduce persistent chest tube drainage after the fontan operation. Am J Cardiol 96:130\u2013133. https:\/\/doi.org\/10.1016\/j.amjcard.2005.03.034","journal-title":"Am J Cardiol"},{"key":"3887_CR31","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.jtcvs.2015.06.042","volume":"150","author":"NA Pike","year":"2015","unstructured":"Pike NA, Okuhara CA, Toyama J et al (2015) Reduced pleural drainage, length of stay, and readmissions using a modified Fontan management protocol. J Thorac Cardiovasc Surg 150:481\u2013487. https:\/\/doi.org\/10.1016\/j.jtcvs.2015.06.042","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3887_CR32","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.athoracsur.2014.06.121","volume":"99","author":"RE Sunstrom","year":"2015","unstructured":"Sunstrom RE, Muralidaran A, Gerrah R et al (2015) A defined management strategy improves early outcomes after the Fontan procedure: the PORTLAND protocol. Ann Thorac Surg 99:148\u2013155. https:\/\/doi.org\/10.1016\/j.athoracsur.2014.06.121","journal-title":"Ann Thorac Surg"},{"key":"3887_CR33","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1510\/icvts.2009.218586","volume":"10","author":"M Gewillig","year":"2010","unstructured":"Gewillig M, Brown SC, Heying R et al (2010) Volume load paradox while preparing for the Fontan: not too much for the ventricle, not too little for the lungs. Interact Cardiovasc Thorac Surg 10:262\u2013265. https:\/\/doi.org\/10.1510\/icvts.2009.218586","journal-title":"Interact Cardiovasc Thorac Surg"}],"updated-by":[{"DOI":"10.1007\/s00246-025-03900-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000}}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-03887-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-025-03887-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-03887-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:02:01Z","timestamp":1770879721000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-025-03887-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["3887"],"URL":"https:\/\/doi.org\/10.1007\/s00246-025-03887-5","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,10]]},"assertion":[{"value":"13 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00246-025-03900-x","URL":"https:\/\/doi.org\/10.1007\/s00246-025-03900-x","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}