{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:51:49Z","timestamp":1789771909152,"version":"4.0.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Heart, Lung, And Blood Institute of the National Institutes of Health","award":["R01HL110957"],"award-info":[{"award-number":["R01HL110957"]}]},{"name":"National Institute of Diabetes, And Digestive, And Kidney Diseases (NIDDK) of the National Institutes of Health","award":["K23 DK125668"],"award-info":[{"award-number":["K23 DK125668"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Understanding relationships between specific measures of adiposity and heart rate variability (HRV) allows for better understanding obesity as a risk factor for cardiovascular and autonomic dysfunction. We sought to examine associations between specific adiposity depots and cardiovascular autonomic function assessed via HRV among children and adolescents. We performed a secondary cross-sectional analysis of a previously completed study of 8\u201317-year-olds (n\u2009=\u2009325; 12.4\u2009\u00b1\u20092.7\u00a0years). Adiposity was assessed via dual x-ray absorptiometry. Resting HRV measures included root mean square of successive differences (RMSSD), percentage of successive normal-to-normal intervals differing by more than 50\u00a0ms (pNN50), low frequency power (LF), high frequency power (HF), and low frequency-to-high frequency ratio (LF:HF). Associations between adiposity and HRV were evaluated using linear regression modeling, adjusting for sex and Tanner stage. RMSSD and pNN50 were both negatively associated with total fat (\u03b2\u2009=\u2009\u2212\u00a00.558,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004; \u03b2\u2009=\u2009\u2212\u00a00.178,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034), percent body fat (\u03b2\u2009=\u2009\u2212\u00a00.790,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007; \u03b2\u2009=\u2009\u2212\u00a00.296,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019), trunk fat (\u03b2\u2009=\u2009\u2212\u00a01.024,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004; \u03b2\u2009=\u2009\u2212\u00a00.344,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022), android fat (\u03b2\u2009=\u2009\u2212\u00a00.005,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006; \u03b2\u2009=\u2009\u2212\u00a00.002,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028), gynoid fat (\u03b2\u2009=\u2009\u2212\u00a00.003,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005; \u03b2\u2009=\u2009\u2212\u00a00.001,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034), visceral adipose tissue (\u03b2\u2009=\u2009\u2212\u00a00.013,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016; \u03b2\u2009=\u2009\u2212\u00a00.005,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038) and subcutaneous abdominal adipose tissue (\u03b2\u2009=\u2009\u2212\u00a00.007,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004; \u03b2\u2009=\u2009\u2212\u00a00.003,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017). RMSSD was negatively associated with appendicular fat (\u03b2\u2009=\u2009\u2212\u00a01.152,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). Visceral adipose tissue was associated positively with LF and LF: HF (\u03b2\u2009=\u20090.004,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028; \u03b2\u2009=\u20090.019,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033) and negatively with HF (\u03b2\u2009=\u2009\u2212\u00a00.004,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028). We found that excess total and regional adiposity may have negative effects on cardiovascular autonomic nervous system function in a large cohort of children and adolescents. Longitudinal studies are needed to confirm and determine how these relationships change over time\n                    <jats:bold>.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00246-025-03924-3","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:56:08Z","timestamp":1752141368000},"page":"1490-1500","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationships Between Adiposity Measures and Heart Rate Variability in Children and Adolescents"],"prefix":"10.1007","volume":"47","author":[{"given":"William T.","family":"Juckett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Evanoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron S.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Bomberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R.","family":"Dengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"3924_CR1","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1056\/nejmoa1502821","volume":"373","author":"AC Skinner","year":"2015","unstructured":"Skinner AC, Perrin EM, Moss LA, Skelton JA (2015) Cardiometabolic risks and severity of obesity in children and young adults. 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