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Concurrently, he developed a relapse of his B-cell ALL as demonstrated by the presence of lymphoblasts in his cerebrospinal fluid. The decision was made to proceed with surgical repair of the aneurysm prior to initiation of systemic chemotherapy. The patient underwent a successful repair of the aneurysm through repair of the mitral valve annular disruption. The aneurysm is likely to be due to partially treated endocarditis, weakening the mitral valve atrioventricular junction, resulting in dehiscence. Recovery post-operatively was uneventful and he was able to undergo CAR-T cell therapy several months later.<\/jats:p>","DOI":"10.1007\/s00246-025-03947-w","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T12:07:15Z","timestamp":1752235635000},"page":"1848-1851","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acquired Submitral Aneurysm in an Adolescent with Relapse of B-cell Acute Lymphoblastic Leukemia and History of Multiple Systemic Infections: A Case Report"],"prefix":"10.1007","volume":"47","author":[{"given":"Colin J.","family":"Crilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Winlaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cornicelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"issue":"8","key":"3947_CR1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/jocs.12789","volume":"31","author":"V Manuel","year":"2016","unstructured":"Manuel V, Sousa-Uva M, Miguel G et al (2016) Submitral aneurysm in children. 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