{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:25:12Z","timestamp":1790105112831,"version":"4.0.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00246-025-04004-2","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:41:54Z","timestamp":1756312914000},"page":"2121-2126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interrupted Inferior Caval Vein in the Era of High Prenatal Detection Highlighting Postnatal Computed Tomographic Findings in Those Without Complex Cardiac Malformations"],"prefix":"10.1007","volume":"47","author":[{"given":"William N.","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben J.","family":"Acherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"4004_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.genom.4.070802.110428","volume":"4","author":"BW Bisgrove","year":"2003","unstructured":"Bisgrove BW, Morelli SH, Yost HJ (2003) Genetics of human laterality disorders: insights from vertebrate model systems. Annu Rev Genomics Hum Genet 4:1\u201332. https:\/\/doi.org\/10.1146\/annurev.genom.4.070802.110428","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"4","key":"4004_CR2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrg1830","volume":"7","author":"A Raya","year":"2006","unstructured":"Raya A, Izpis\u00faa Belmonte JC (2006) Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nat Rev Genet 7(4):283\u2013293. https:\/\/doi.org\/10.1038\/nrg1830","journal-title":"Nat Rev Genet"},{"issue":"1","key":"4004_CR3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41588-021-00970-4","volume":"54","author":"E Szenker-Ravi","year":"2022","unstructured":"Szenker-Ravi E, Ott T, Khatoo M et al (2022) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nat Genet 54(1):62\u201372. https:\/\/doi.org\/10.1038\/s41588-021-00970-4","journal-title":"Nat Genet"},{"issue":"1","key":"4004_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd5010011","volume":"5","author":"RH Anderson","year":"2018","unstructured":"Anderson RH, Spicer DE, Loomba R (2018) Is an appreciation of isomerism the key to unlocking the mysteries of the cardiac findings in heterotaxy? J Cardiovasc Dev Dis 5(1):11. https:\/\/doi.org\/10.3390\/jcdd5010011","journal-title":"J Cardiovasc Dev Dis"},{"key":"4004_CR5","doi-asserted-by":"publisher","first-page":"101149","DOI":"10.1016\/j.ppedcard.2019.101149","volume":"55","author":"WN Evans","year":"2019","unstructured":"Evans WN, Acherman RJ, Restrepo H (2019) Determining situs by abdominal aorta and inferior vena caval findings: it is neither complicated nor ambiguus. Prog Pediatr Cardiol 55:101149. https:\/\/doi.org\/10.1016\/j.ppedcard.2019.101149","journal-title":"Prog Pediatr Cardiol"},{"issue":"2","key":"4004_CR6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4103\/apc.APC_171_16","volume":"10","author":"S Mori","year":"2017","unstructured":"Mori S, Anderson RH, Nishii T, Matsumoto K, Loomba RS (2017) Isomerism in the setting of the so-called \u201cheterotaxy\u201d: the usefulness of computed tomographic analysis. Ann Pediatr Cardiol 10(2):175\u2013186. https:\/\/doi.org\/10.4103\/apc.APC_171_16","journal-title":"Ann Pediatr Cardiol"},{"issue":"24","key":"4004_CR7","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1136\/hrt.2009.165514","volume":"95","author":"S Pepes","year":"2009","unstructured":"Pepes S, Zidere V, Allan LD (2009) Prenatal diagnosis of left atrial isomerism. Heart 95(24):1974\u20131977. https:\/\/doi.org\/10.1136\/hrt.2009.165514","journal-title":"Heart"},{"issue":"3","key":"4004_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1148\/101.3.511","volume":"101","author":"TJ Vaughan","year":"1971","unstructured":"Vaughan TJ, Hawkins IF Jr., Elliott LP (1971) Diagnosis of polysplenia syndrome. Radiology 101(3):511\u2013518. https:\/\/doi.org\/10.1148\/101.3.511","journal-title":"Radiology"},{"issue":"2","key":"4004_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1136\/hrt.48.2.97","volume":"48","author":"JC Huhta","year":"1982","unstructured":"Huhta JC, Smallhorn JF, Macartney FJ (1982) Two-dimensional echocardiographic diagnosis of situs. Br Heart J 48(2):97\u2013108. https:\/\/doi.org\/10.1136\/hrt.48.2.97","journal-title":"Br Heart J"},{"issue":"5","key":"4004_CR10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.7863\/jum.1995.14.5.381","volume":"14","author":"RC Sheley","year":"1995","unstructured":"Sheley RC, Nyberg DA, Kapur R (1995) Azygous continuation of the interrupted inferior vena cava: a clue to prenatal diagnosis of the cardiosplenic syndromes. J Ultrasound Med 14(5):381\u2013387. https:\/\/doi.org\/10.7863\/jum.1995.14.5.381","journal-title":"J Ultrasound Med"},{"issue":"12","key":"4004_CR11","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/s0002-9149(96)00137-3","volume":"77","author":"CK Phoon","year":"1996","unstructured":"Phoon CK, Villegas MD, Ursell PC, Silverman NH (1996) Left atrial isomerism detected in fetal life. Am J Cardiol 77(12):1083\u20131088. https:\/\/doi.org\/10.1016\/s0002-9149(96)00137-3","journal-title":"Am J Cardiol"},{"issue":"1","key":"4004_CR12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2214\/ajr.177.1.1770120","volume":"177","author":"F Slosman","year":"2001","unstructured":"Slosman F, Schmid MR, Pfammatter T (2001) Agenesis of the hepatic segment of the inferior vena cava with portal continuation. AJR Am J Roentgenol 177(1):120\u2013122. https:\/\/doi.org\/10.2214\/ajr.177.1.1770120","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"4004_CR13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/joa.12266","volume":"226","author":"JP Hikspoors","year":"2015","unstructured":"Hikspoors JP, Soffers JH, Mekonen HK, Cornillie P, K\u00f6hler SE, Lamers WH (2015) Development of the human infrahepatic inferior caval and azygos venous systems. J Anat 226(2):113\u2013125. https:\/\/doi.org\/10.1111\/joa.12266","journal-title":"J Anat"},{"issue":"3","key":"4004_CR14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/0002-9149(86)90074-3","volume":"58","author":"DW Sapire","year":"1986","unstructured":"Sapire DW, Ho SY, Anderson RH, Rigby ML (1986) Diagnosis and significance of atrial isomerism. Am J Cardiol 58(3):342\u2013346. https:\/\/doi.org\/10.1016\/0002-9149(86)90074-3","journal-title":"Am J Cardiol"},{"issue":"2","key":"4004_CR15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1136\/hrt.63.2.122","volume":"63","author":"C Anderson","year":"1990","unstructured":"Anderson C, Devine WA, Anderson RH, Debich DE, Zuberbuhler JR (1990) Abnormalities of the spleen in relation to congenital malformations of the heart: a survey of necropsy findings in children. Br Heart J 63(2):122\u2013128. https:\/\/doi.org\/10.1136\/hrt.63.2.122","journal-title":"Br Heart J"},{"issue":"6","key":"4004_CR16","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1017\/S1047951105001708","volume":"15","author":"RM Freedom","year":"2005","unstructured":"Freedom RM, Jaeggi ET, Lim JS, Anderson RH (2005) Hearts with isomerism of the right atrial appendages - one of the worst forms of disease in 2005. Cardiol Young 15(6):554\u2013567. https:\/\/doi.org\/10.1017\/S1047951105001708","journal-title":"Cardiol Young"},{"issue":"7","key":"4004_CR17","doi-asserted-by":"publisher","first-page":"921","DOI":"10.7863\/jum.2005.24.7.921","volume":"24","author":"C Berg","year":"2005","unstructured":"Berg C, Geipel A, Kamil D et al (2005) The syndrome of left isomerism: sonographic findings and outcome in prenatally diagnosed cases. J Ultrasound Med 24(7):921\u2013931. https:\/\/doi.org\/10.7863\/jum.2005.24.7.921","journal-title":"J Ultrasound Med"},{"issue":"4","key":"4004_CR18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/uog.14871","volume":"47","author":"I Gottschalk","year":"2016","unstructured":"Gottschalk I, Stressig R, Ritgen J et al (2016) Extracardiac anomalies in prenatally diagnosed heterotaxy syndrome. Ultrasound Obstet Gynecol 47(4):443\u2013449. https:\/\/doi.org\/10.1002\/uog.14871","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"4004_CR19","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/s0735-1097(00)00812-3","volume":"36","author":"T Gilljam","year":"2000","unstructured":"Gilljam T, McCrindle BW, Smallhorn JF, Williams WG, Freedom RM (2000) Outcomes of left atrial isomerism over a 28-year period at a single institution. J Am Coll Cardiol 36(3):908\u2013916. https:\/\/doi.org\/10.1016\/s0735-1097(00)00812-3","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"4004_CR20","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/jcu.23209","volume":"50","author":"K Babao\u011flu","year":"2022","unstructured":"Babao\u011flu K, Do\u011fan Y, Ba\u015far EZ, Usta E (2022) Prenatal diagnosis of hepatic interruption of the inferior vena cava with azygos\/hemiazygos continuation without structural heart defects: a case series. J Clin Ultrasound 50(6):795\u2013802. https:\/\/doi.org\/10.1002\/jcu.23209","journal-title":"J Clin Ultrasound"},{"issue":"2","key":"4004_CR21","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/pd.6739","volume":"45","author":"WN Evans","year":"2025","unstructured":"Evans WN, Acherman RJ, Kip KT et al (2025) Approaching universal prenatal detection of significant cardiovascular malformations in Nevada. Prenat Diagn 45(2):196\u2013203. https:\/\/doi.org\/10.1002\/pd.6739","journal-title":"Prenat Diagn"},{"key":"4004_CR22","unstructured":"https:\/\/search.cdc.gov\/search\/?query=NEVADA&siteLimit=NCHS&dpage=1, Accessed 15 Dec 2024"},{"issue":"Suppl 104","key":"4004_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1651-2227.1955.tb05346.x","volume":"44","author":"BI Ivemark","year":"1955","unstructured":"Ivemark BI (1955) Implications of agenesis of the spleen on the pathogenesis of conotruncus anomalies in childhood; an analysis of the heart malformations in the splenic agenesis syndrome, with fourteen new cases. Acta Paediatr Suppl (Upps) 44(Suppl 104):7\u2013110","journal-title":"Acta Paediatr Suppl (Upps)"},{"key":"4004_CR24","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/0002-9149(64)90159-6","volume":"13","author":"R Vanpraagh","year":"1964","unstructured":"Vanpraagh R, Vanpraagh S, Vlad P, Keith JD (1964) Anatomic types of congenital dextrocardia: diagnostic and embryologic implications. Am J Cardiol 13:510\u2013531. https:\/\/doi.org\/10.1016\/0002-9149(64)90159-6","journal-title":"Am J Cardiol"},{"issue":"5","key":"4004_CR25","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1148\/87.5.859","volume":"87","author":"LP Elliott","year":"1966","unstructured":"Elliott LP, Cramer GG, Amplatz K (1966) The anomalous relationship of the inferior vena cava and abdominal aorta as a specific angiocardiographic sign in asplenia. Radiology 87(5):859\u2013863. https:\/\/doi.org\/10.1148\/87.5.859","journal-title":"Radiology"},{"issue":"3","key":"4004_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/00125817-200005000-00002","volume":"2","author":"AE Lin","year":"2000","unstructured":"Lin AE, Ticho BS, Houde K, Westgate MN, Holmes LB (2000) Heterotaxy: associated conditions and hospital-based prevalence in newborns. Genet Med 2(3):157\u2013172. https:\/\/doi.org\/10.1097\/00125817-200005000-00002","journal-title":"Genet Med"},{"issue":"1","key":"4004_CR27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s13023-022-02515-2","volume":"17","author":"TG Saba","year":"2022","unstructured":"Saba TG, Geddes GC, Ware SM et al (2022) A multi-disciplinary, comprehensive approach to management of children with heterotaxy. Orphanet J Rare Dis 17(1):351. https:\/\/doi.org\/10.1186\/s13023-022-02515-2","journal-title":"Orphanet J Rare Dis"},{"issue":"3","key":"4004_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0002-9149(90)90090-n","volume":"65","author":"K Momma","year":"1990","unstructured":"Momma K, Takao A, Shibata T (1990) Characteristics and natural history of abnormal atrial rhythms in left isomerism. Am J Cardiol 65(3):231\u2013236. https:\/\/doi.org\/10.1016\/0002-9149(90)90090-n","journal-title":"Am J Cardiol"},{"issue":"6","key":"4004_CR29","doi-asserted-by":"publisher","first-page":"B2","DOI":"10.1016\/j.ajog.2020.02.040","volume":"222","author":"CA Combs","year":"2020","unstructured":"Combs CA, Hameed AB, Friedman AM, Hoskins IA (2020) Special statement: proposed quality metrics to assess accuracy of prenatal detection of congenital heart defects. Am J Obstet Gynecol 222(6):B2\u2013B9. https:\/\/doi.org\/10.1016\/j.ajog.2020.02.040","journal-title":"Am J Obstet Gynecol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-04004-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-025-04004-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-04004-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:16:52Z","timestamp":1777994212000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-025-04004-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["4004"],"URL":"https:\/\/doi.org\/10.1007\/s00246-025-04004-2","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]},"assertion":[{"value":"23 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national guidelines on human experimentation (Belmont Report) and with the Helsinki Declaration of 1975, as revised in 2008, and has been approved by the Institutional Committees of Sunrise Hospital and Medical Center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}