{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:00:31Z","timestamp":1790114431965,"version":"4.0.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00246-025-04071-5","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T16:10:22Z","timestamp":1760803822000},"page":"2910-2913","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between G6PD Deficiency and Congenital Heart Disease Incidence and Hospital Outcomes"],"prefix":"10.1007","volume":"47","author":[{"given":"Alana M.","family":"Hendrickson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie E.","family":"Caryl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Meziab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent J.","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-5723","authenticated-orcid":false,"given":"Michael D.","family":"Seckeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"4071_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.hoc.2015.11.006","volume":"30","author":"L Luzzatto","year":"2016","unstructured":"Luzzatto L, Nannelli C, Notaro R (2016) Glucose-6-Phosphate Dehydrogenase Deficiency. Hematol Oncol Clin North Am 30:373\u201393. https:\/\/doi.org\/10.1016\/j.hoc.2015.11.006","journal-title":"Hematol Oncol Clin North Am"},{"key":"4071_CR2","unstructured":"Richardson SR, O'Malley GF (2025) Glucose-6-Phosphate Dehydrogenase Deficiency. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing 2025 Jan.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470315\/"},{"key":"4071_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105904","volume":"173","author":"M Koromina","year":"2021","unstructured":"Koromina M, Pandi MT, van der Spek PJ, Patrinos GP, Lauschke VM (2021) The ethnogeographic variability of genetic factors underlying G6PD deficiency. Pharmacol Res 173:105904. https:\/\/doi.org\/10.1016\/j.phrs.2021.105904","journal-title":"Pharmacol Res"},{"key":"4071_CR4","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1182\/blood.2019000944","volume":"136","author":"L Luzzatto","year":"2020","unstructured":"Luzzatto L, Ally M, Notaro R (2020) Glucose-6-phosphate dehydrogenase deficiency. Blood 136:1225\u20131240. https:\/\/doi.org\/10.1182\/blood.2019000944","journal-title":"Blood"},{"key":"4071_CR5","first-page":"572","volume":"40","author":"J Bubp","year":"2015","unstructured":"Bubp J, Jen M, Matuszewski K (2015) Caring for glucose-6-phosphate dehydrogenase (G6PD)-deficient patients: implications for pharmacy. P T 40:572\u20134","journal-title":"P T"},{"key":"4071_CR6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1161\/CIRCHEARTFAILURE.112.969576","volume":"6","author":"PA Hecker","year":"2013","unstructured":"Hecker PA, Lionetti V, Ribeiro R et al (2013) Glucose 6-phosphate dehydrogenase deficiency increases redox stress and moderately accelerates the development of heart failure. Circ Heart Fail 6:118\u201326. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.112.969576","journal-title":"Circ Heart Fail"},{"key":"4071_CR7","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1161\/01.CIR.0000112605.43318.CA","volume":"109","author":"M Jain","year":"2004","unstructured":"Jain M, Cui L, Brenner DA et al (2004) Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation 109:898\u2013903. https:\/\/doi.org\/10.1161\/01.CIR.0000112605.43318.CA","journal-title":"Circulation"},{"key":"4071_CR8","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1096\/fj.00-0893fje","volume":"15","author":"JA Leopold","year":"2001","unstructured":"Leopold JA, Cap A, Scribner AW, Stanton RC, Loscalzo J (2001) Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. FASEB J 15:1771\u20133. https:\/\/doi.org\/10.1096\/fj.00-0893fje","journal-title":"FASEB J"},{"key":"4071_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.atherosclerosis.2019.01.027","volume":"282","author":"GM Pes","year":"2019","unstructured":"Pes GM, Parodi G, Dore MP (2019) Glucose-6-phosphate dehydrogenase deficiency and risk of cardiovascular disease: a propensity score-matched study. Atherosclerosis 282:148\u2013153. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2019.01.027","journal-title":"Atherosclerosis"},{"key":"4071_CR10","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1442-200X.2011.03478.x","volume":"54","author":"AG Pirinccioglu","year":"2012","unstructured":"Pirinccioglu AG, Alyan O, Kizil G, Kangin M, Beyazit N (2012) Evaluation of oxidative stress in children with congenital heart defects. Pediatr Int 54:94\u20138. https:\/\/doi.org\/10.1111\/j.1442-200X.2011.03478.x","journal-title":"Pediatr Int"},{"key":"4071_CR11","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1080\/10715762.2023.2284639","volume":"57","author":"I Vanreusel","year":"2023","unstructured":"Vanreusel I, Taeymans J, Van Craenenbroeck E et al (2023) Elevated oxidative stress in patients with congenital heart disease and the effect of cyanosis: a meta-analysis. Free Radic Res 57:470\u2013486. https:\/\/doi.org\/10.1080\/10715762.2023.2284639","journal-title":"Free Radic Res"},{"key":"4071_CR12","unstructured":"Vizient\u00ae Clinical Data Base. www.vizientinc.com. Accessed 8 May 2024"},{"key":"4071_CR13","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1016\/j.jacc.2018.08.1028","volume":"73","author":"KK Stout","year":"2018","unstructured":"Stout KK, Daniels CJ, Aboulhosn JA et al (2018) 2018 AHA\/ACC Guideline for the Management of Adults With Congenital Heart Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 73:1494\u20131563. https:\/\/doi.org\/10.1016\/j.jacc.2018.08.1028","journal-title":"J Am Coll Cardiol"},{"key":"4071_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijns4040034","volume":"4","author":"A Anderle","year":"2018","unstructured":"Anderle A, Bancone G, Domingo GJ, Gerth-Guyette E, Pal S, Satyagraha AW (2018) Point-of-care testing for G6PD deficiency: opportunities for screening. Int J Neonatal Screen 4:34. https:\/\/doi.org\/10.3390\/ijns4040034","journal-title":"Int J Neonatal Screen"},{"key":"4071_CR15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-065900","volume":"154","author":"S Milburn","year":"2024","unstructured":"Milburn S, Bhutani VK, Weintraub A, Guttmann K (2024) Implementation of universal screening for G6PD deficiency in newborns. Pediatrics 154:e2024065900. https:\/\/doi.org\/10.1542\/peds.2024-065900","journal-title":"Pediatrics"},{"key":"4071_CR16","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.athoracsur.2024.01.009","volume":"117","author":"M Hosseini","year":"2024","unstructured":"Hosseini M, Griffeth EM, Schaff HV et al (2024) Analysis of anemia, transfusions, and CABG outcomes in the Society of Thoracic Surgeons national database. Ann Thorac Surg 117:1053\u20131060. https:\/\/doi.org\/10.1016\/j.athoracsur.2024.01.009","journal-title":"Ann Thorac Surg"},{"key":"4071_CR17","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/labinvest.2014.144","volume":"95","author":"PA Kramer","year":"2015","unstructured":"Kramer PA, Chacko BK, Ravi S et al (2015) Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients. Lab Invest 95:132\u201341. https:\/\/doi.org\/10.1038\/labinvest.2014.144","journal-title":"Lab Invest"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-04071-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-025-04071-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-04071-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:04:41Z","timestamp":1790111081000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-025-04071-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,18]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["4071"],"URL":"https:\/\/doi.org\/10.1007\/s00246-025-04071-5","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,18]]},"assertion":[{"value":"23 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}