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This study investigated the prevalence and early impacts of aortic regurgitation in a newborn cohort.\u00a0Between April 2016 and October 2018, all newborns in the Copenhagen Area were offered systematic transthoracic echocardiography in a prospective, multicenter population-based study. Aortic valve function was categorized as no, trivial (glimpse of regurgitant flow and\/or vena contracta\u2009&lt;\u20090.1\u00a0cm), or non-trivial aortic regurgitation (vena contracta\u2009\u2265\u20090.1\u00a0cm). Newborns with non-trivial regurgitation were matched 1:4 with controls (no regurgitation).\u00a0Among 25,590 newborns, aortic regurgitation was detected in 329 newborns (52% male, median age 11 days), i.e. a prevalence of 1.3% (95% CI, 1.15%-1.43%), with 260 (79%) classified as trivial and 69 (21%) as non-trivial. Bicuspid aortic valve was more common in newborns with non-trivial regurgitation (13.0%) than controls (1.1%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Newborns with non-trivial regurgitation had larger aortic dimensions compared to controls (mean\u2009\u00b1\u2009SD): aortic valve annulus (7.3\u2009\u00b1\u20090.7\u00a0mm vs. 7.0\u2009\u00b1\u20090.6\u00a0mm), Sinuses of Valsalva (10.3\u2009\u00b1\u20091.0\u00a0mm vs. 9.7\u2009\u00b1\u20091.0\u00a0mm), sino-tubular junction (8.4\u2009\u00b1\u20090.8\u00a0mm vs. 8.0\u2009\u00b1\u20090.8\u00a0mm), and ascending aorta diameter (10.0\u2009\u00b1\u20090.9\u00a0mm vs. 9.4\u2009\u00b1\u20091.1\u00a0mm) (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.006). Left ventricular dimensions and function did not differ between groups.\u00a0Congenital aortic regurgitation was present in 1.3% of all newborns. Non-trivial regurgitation (0.3%) was associated with larger aortic dimensions and higher prevalence of bicuspid aortic valve (13%), but no early signs of left ventricular impairment. Follow-up will help identify those at risk of progression, potentially due to valvular and\/or aortic pathology, who may benefit from regular surveillance, and those who can be safely discontinued.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Trial registration<\/jats:italic>\n                    \u00a0ClinicalTrials.gov NCT02753348 (registered April 27th 2016).\n                  <\/jats:p>","DOI":"10.1007\/s00246-025-04149-0","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:21:05Z","timestamp":1768872065000},"page":"3484-3491","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Congenital Aortic Valve Regurgitation in a Newborn Cohort"],"prefix":"10.1007","volume":"47","clinical-trial-number":[{"clinical-trial-number":"nct02753348","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Aysha F.","family":"Farooqui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob B.","family":"Norsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Hjortdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian K.","family":"Bjerrekaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Reindahl","family":"Fagerlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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