{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:40:18Z","timestamp":1792600818821,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00246-025-04152-5","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:40:47Z","timestamp":1767969647000},"page":"3600-3603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rapid Regression of Myocardial Hypertrophy with First-Line Avalglucosidase Alfa in Infantile-Onset Pompe Disease: A Case Report"],"prefix":"10.1007","volume":"47","author":[{"given":"Natsumi","family":"Uemura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Ehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"4152_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36110","author":"PS Kishnani","year":"2013","unstructured":"Kishnani PS, Amartino HM, Lindberg C, Miller TM, Wilson A, Keutzer J (2013) Timing of diagnosis of patients with Pompe disease: data from the Pompe registry. Am J Med Genet A. https:\/\/doi.org\/10.1002\/ajmg.a.36110","journal-title":"Am J Med Genet A"},{"key":"4152_CR2","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1542\/peds.112.2.332","volume":"112","author":"HMP van den Hout","year":"2003","unstructured":"van den Hout HMP, Hop W, van Diggelen OP, Smeitink JAM, Smit GPA, Poll-The B-TT et al (2003) The natural course of infantile pompe\u2019s disease: 20 original cases compared with 133 cases from the literature. Pediatrics 112:332\u2013340. https:\/\/doi.org\/10.1542\/peds.112.2.332","journal-title":"Pediatrics"},{"key":"4152_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2025.114664","volume":"285","author":"D Kronn","year":"2025","unstructured":"Kronn D, Davison J, Broomfield A, Brassier A, Labarthe F, Hahn SH et al (2025) The mini-COMET clinical trial: safety and efficacy of avalglucosidase alfa after 97 weeks of treatment in children with infantile-onset Pompe disease previously treated with alglucosidase alfa. J Pediatr 285:114664","journal-title":"J Pediatr"},{"key":"4152_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13266-y","volume":"272","author":"PS Kishnani","year":"2025","unstructured":"Kishnani PS, D\u00edaz-Manera J, Illarioshkin S, van der Ploeg AT, Clemens PR, Day JW et al (2025) Efficacy and safety of avalglucosidase alfa in patients with late-onset Pompe disease after 145 weeks of treatment during the COMET trial. J Neurol 272:581","journal-title":"J Neurol"},{"key":"4152_CR5","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/mt.2009.37","volume":"17","author":"Y Zhu","year":"2009","unstructured":"Zhu Y, Jiang J-L, Gumlaw NK, Zhang J, Bercury SD, Ziegler RJ et al (2009) Glycoengineered acid \u03b1-glucosidase with improved efficacy at correcting the metabolic aberrations and motor function deficits in a mouse model of Pompe disease. Mol Ther 17:954\u2013963. https:\/\/doi.org\/10.1038\/mt.2009.37","journal-title":"Mol Ther"},{"key":"4152_CR6","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s00246-008-9267-3","volume":"29","author":"JC Levine","year":"2008","unstructured":"Levine JC, Kishnani PS, Chen YT, Herlong JR, Li JS (2008) Cardiac remodeling after enzyme replacement therapy with acid \u03b1-glucosidase for infants with Pompe disease. Pediatr Cardiol 29:1033\u20131042. https:\/\/doi.org\/10.1007\/s00246-008-9267-3","journal-title":"Pediatr Cardiol"},{"key":"4152_CR7","doi-asserted-by":"publisher","first-page":"e1116","DOI":"10.1542\/peds.2008-3667","volume":"124","author":"YH Chien","year":"2009","unstructured":"Chien YH, Lee NC, Thurberg BL, Chiang SC, Zhang XK, Keutzer J et al (2009) Pompe disease in infants: improving the prognosis by newborn screening and early treatment. Pediatrics 124:e1116\u2013e1125. https:\/\/doi.org\/10.1542\/peds.2008-3667","journal-title":"Pediatrics"},{"key":"4152_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.pedneo.2013.03.009","volume":"54","author":"YH Chien","year":"2013","unstructured":"Chien YH, Hwu WL, Lee NC (2013) Pompe disease: early diagnosis and early treatment make a difference. Pediatr Neonatol 54:219\u2013227. https:\/\/doi.org\/10.1016\/j.pedneo.2013.03.009","journal-title":"Pediatr Neonatol"},{"key":"4152_CR9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1212\/01.wnl.0000251268.41188.04","volume":"68","author":"PS Kishnani","year":"2007","unstructured":"Kishnani PS, Corzo D, Nicolino M, Byrne B, Mandel H et al (2007) Recombinant human acid \u03b1-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology 68:99\u2013109. https:\/\/doi.org\/10.1212\/01.wnl.0000251268.41188.04","journal-title":"Neurology"},{"key":"4152_CR10","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1399-0004.1988.tb03465.x","volume":"33","author":"Y Suzuki","year":"1988","unstructured":"Suzuki Y, Tsuji A, Omura K, Nakamura G, Awa S, Kroos M, Reuser AJJ (1988) Km mutant of acid \u03b1-glucosidase in a case of cardiomyopathy without signs of skeletal muscle involvement. Clin Genet 33:376\u2013385. https:\/\/doi.org\/10.1111\/j.1399-0004.1988.tb03465.x","journal-title":"Clin Genet"},{"key":"4152_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijns6030072","volume":"6","author":"EG Ames","year":"2020","unstructured":"Ames EG, Fisher R, Kleyn M, Ahmad A (2020) Current practices for U.S. newborn screening of Pompe disease and MPSI. Int J Neonatal Screen 6:72. https:\/\/doi.org\/10.3390\/ijns6030072","journal-title":"Int J Neonatal Screen"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-04152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-025-04152-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-025-04152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:53:10Z","timestamp":1792597990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-025-04152-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["4152"],"URL":"https:\/\/doi.org\/10.1007\/s00246-025-04152-5","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]},"assertion":[{"value":"9 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}