{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:05:52Z","timestamp":1772445952049,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"DOI":"10.1007\/s00246-026-04208-0","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T09:22:18Z","timestamp":1772443338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ebstein Anomaly Fetal Echocardiogram Parameters are Associated with Illness Severity on Admission to the Cardiac Intensive Care Unit"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-9764","authenticated-orcid":false,"given":"Jason S.","family":"Kerstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-7385","authenticated-orcid":false,"given":"Alyssa R.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-8218","authenticated-orcid":false,"given":"Diana L.","family":"Geisser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-7100","authenticated-orcid":false,"given":"Christina","family":"Ronai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-2158","authenticated-orcid":false,"given":"Wayne","family":"Tworetzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-1988","authenticated-orcid":false,"given":"Christopher W.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-1389","authenticated-orcid":false,"given":"Stuart","family":"Lipsitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6244-027X","authenticated-orcid":false,"given":"Yuanyuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1344-2354","authenticated-orcid":false,"given":"Elisabeth A.","family":"Kaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-0444","authenticated-orcid":false,"given":"Eleonore","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-7256","authenticated-orcid":false,"given":"Sarah A.","family":"Teele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"4208_CR1","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","volume":"39","author":"JI Hoffman","year":"2002","unstructured":"Hoffman JI, Kaplan S (2002) The incidence of congenital heart disease. J Am Coll Cardiol 39:1890\u20131900","journal-title":"J Am Coll Cardiol"},{"key":"4208_CR2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/tera.1420500208","volume":"50","author":"A Correa-Villasenor","year":"1994","unstructured":"Correa-Villasenor A, Ferencz C, Neill CA, Wilson PD, Boughman JA (1994) Ebstein\u2019s malformation of the tricuspid valve: genetic and environmental factors. The Baltimore-Washington Infant Study Group. Teratology 50:137\u2013147","journal-title":"Teratology"},{"key":"4208_CR3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1161\/CIRCULATIONAHA.106.619338","volume":"115","author":"CH Attenhofer Jost","year":"2007","unstructured":"Attenhofer Jost CH, Connolly HM, Dearani JA, Edwards WD, Danielson GK (2007) Ebstein\u2019s anomaly. Circulation 115:277\u2013285","journal-title":"Circulation"},{"key":"4208_CR4","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1161\/CIRCULATIONAHA.115.015839","volume":"132","author":"LR Freud","year":"2015","unstructured":"Freud LR, Escobar-Diaz MC, Kalish BT, Komarlu R, Puchalski MD, Jaeggi ET, Szwast AL, Freire G, Levasseur SM, Kavanaugh-McHugh A, Michelfelder EC, Moon-Grady AJ, Donofrio MT, Howley LW, Tierney ES, Cuneo BF, Morris SA, Pruetz JD, van der Velde ME, Kovalchin JP, Ikemba CM, Vernon MM, Samai C, Satou GM, Gotteiner NL, Phoon CK, Silverman NH, McElhinney DB, Tworetzky W (2015) Outcomes and predictors of perinatal mortality in fetuses with Ebstein anomaly or tricuspid valve dysplasia in the current era: a multicenter study. Circulation 132:481\u2013489","journal-title":"Circulation"},{"key":"4208_CR5","doi-asserted-by":"publisher","first-page":"e016684","DOI":"10.1161\/JAHA.120.016684","volume":"9","author":"LR Freud","year":"2020","unstructured":"Freud LR, McElhinney DB, Kalish BT, Escobar-Diaz MC, Komarlu R, Puchalski MD, Jaeggi ET, Szwast AL, Freire G, Levasseur SM, Kavanaugh-McHugh A, Michelfelder EC, Moon-Grady AJ, Donofrio MT, Howley LW, Selamet Tierney ES, Cuneo BF, Morris SA, Pruetz JD, van der Velde ME, Kovalchin JP, Ikemba CM, Vernon MM, Samai C, Satou GM, Gotteiner NL, Phoon CK, Silverman NH, Tworetzky W (2020) Risk factors for mortality and circulatory outcome among neonates prenatally diagnosed with Ebstein anomaly or tricuspid valve dysplasia: a multicenter study. J Am Heart Assoc 9:e016684","journal-title":"J Am Heart Assoc"},{"key":"4208_CR6","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1177\/2150135111416016","volume":"2","author":"SP Goldberg","year":"2011","unstructured":"Goldberg SP, Jones RC, Boston US, Haddad LM, Wetzel GT, Chin TK, Knott-Craig CJ (2011) Current trends in the management of neonates with Ebstein\u2019s anomaly. World J Pediatr Congenit Heart Surg 2:554\u2013557","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"4208_CR7","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.amjcard.2005.04.024","volume":"96","author":"DB McElhinney","year":"2005","unstructured":"McElhinney DB, Salvin JW, Colan SD, Thiagarajan R, Crawford EC, Marcus EN, del Nido PJ, Tworetzky W (2005) Improving outcomes in fetuses and neonates with congenital displacement (Ebstein\u2019s malformation) or dysplasia of the tricuspid valve. Am J Cardiol 96:582\u2013586","journal-title":"Am J Cardiol"},{"key":"4208_CR8","first-page":"1500","volume":"32","author":"D Wertaschnigg","year":"2016","unstructured":"Wertaschnigg D, Manlhiot C, Jaeggi M, Seed M, Dragulescu A, Schwartz SM, van Arsdell G, Jaeggi ET (2016) Contemporary outcomes and factors associated with mortality after a fetal or neonatal diagnosis of Ebstein anomaly and tricuspid valve disease. Can J Cardiol 32:1500\u20131506","journal-title":"Can J Cardiol"},{"key":"4208_CR9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1053\/j.semtcvs.2017.01.012","volume":"29","author":"JC Luxford","year":"2017","unstructured":"Luxford JC, Arora N, Ayer JG, Verrall CE, Cole AD, Orr Y, d\u2019Udekem Y, Sholler GF, Winlaw DS (2017) Neonatal Ebstein anomaly: a 30-year institutional review. Semin Thorac Cardiovasc Surg 29:206\u2013212","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"4208_CR10","doi-asserted-by":"publisher","first-page":"e172352","DOI":"10.1001\/jamapediatrics.2017.2352","volume":"171","author":"TJ Matics","year":"2017","unstructured":"Matics TJ, Sanchez-Pinto LN (2017) Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the sepsis-3 definitions in critically Ill children. JAMA Pediatr 171:e172352","journal-title":"JAMA Pediatr"},{"key":"4208_CR11","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.amjcard.2007.11.049","volume":"101","author":"RE Andrews","year":"2008","unstructured":"Andrews RE, Tibby SM, Sharland GK, Simpson JM (2008) Prediction of outcome of tricuspid valve malformations diagnosed during fetal life. Am J Cardiol 101:1046\u20131050","journal-title":"Am J Cardiol"},{"key":"4208_CR12","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/0735-1097(92)90291-T","volume":"19","author":"DS Celermajer","year":"1992","unstructured":"Celermajer DS, Cullen S, Sullivan ID, Spiegelhalter DJ, Wyse RK, Deanfield JE (1992) Outcome in neonates with Ebstein\u2019s anomaly. J Am Coll Cardiol 19:1041\u20131046","journal-title":"J Am Coll Cardiol"},{"key":"4208_CR13","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.amjcard.2016.09.022","volume":"119","author":"ES Selamet Tierney","year":"2017","unstructured":"Selamet Tierney ES, McElhinney DB, Freud LR, Tworetzky W, Cuneo BF, Escobar-Diaz MC, Ikemba C, Kalish BT, Komarlu R, Levasseur SM, Puchalski MD, Satou GM, Silverman NH, Moon-Grady AJ (2017) Assessment of progressive pathophysiology after early prenatal diagnosis of the Ebstein anomaly or tricuspid valve dysplasia. Am J Cardiol 119:106\u2013111","journal-title":"Am J Cardiol"},{"key":"4208_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0735-1097(91)90722-L","volume":"17","author":"LK Hornberger","year":"1991","unstructured":"Hornberger LK, Sahn DJ, Kleinman CS, Copel JA, Reed KL (1991) Tricuspid valve disease with significant tricuspid insufficiency in the fetus: diagnosis and outcome. J Am Coll Cardiol 17:167\u2013173","journal-title":"J Am Coll Cardiol"},{"key":"4208_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.amjcard.2020.11.013","volume":"141","author":"LR Freud","year":"2021","unstructured":"Freud LR, Wilkins-Haug LE, Beroukhim RS, LaFranchi T, Phoon CK, Glickstein JS, Cumbermack KM, Makhoul M, Morris SA, Sun HY, Ferrer Q, Pedra SR, Tworetzky W (2021) Effect of In utero non-steroidal anti-inflammatory drug therapy for severe Ebstein anomaly or tricuspid valve dysplasia (NSAID therapy for fetal Ebstein anomaly). Am J Cardiol 141:106\u2013112","journal-title":"Am J Cardiol"},{"key":"4208_CR16","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.amjcard.2005.05.035","volume":"96","author":"RM Wald","year":"2005","unstructured":"Wald RM, Adatia I, Van Arsdell GS, Hornberger LK (2005) Relation of limiting ductal patency to survival in neonatal Ebstein\u2019s anomaly. Am J Cardiol 96:851\u2013856","journal-title":"Am J Cardiol"},{"key":"4208_CR17","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3233\/NPM-200626","volume":"14","author":"N Sethi","year":"2021","unstructured":"Sethi N, Klugman D, Said M, Hom L, Bowers S, Berger JT, Wernovsky G, Donofrio MT (2021) Standardized delivery room management for neonates with a prenatal diagnosis of congenital heart disease: a model for improving interdisciplinary delivery room care. J Neonatal Perinat Med 14:317\u2013329","journal-title":"J Neonatal Perinat Med"},{"key":"4208_CR18","doi-asserted-by":"crossref","unstructured":"Thomas AR, Geisser D, Kaza E, Allan C, Abdulhayoglu E, Flanigan E, Dionne A, Kerstein J, Valencia E, Manning S, Goldberg S (2026) Importance of clinical practice guidelines for specialized delivery room resuscitation of newborns with prenatally diagnosed critical congenital heart disease. J Perinatol","DOI":"10.1038\/s41372-025-02552-2"},{"key":"4208_CR19","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/S0003-4975(00)01138-3","volume":"69","author":"CJ Knott-Craig","year":"2000","unstructured":"Knott-Craig CJ, Overholt ED, Ward KE, Razook JD (2000) Neonatal repair of Ebstein\u2019s anomaly: indications, surgical technique, and medium-term follow-up. Ann Thorac Surg 69:1505\u20131510","journal-title":"Ann Thorac Surg"},{"key":"4208_CR20","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1053\/j.optechstcvs.2008.03.002","volume":"13","author":"BL Reemtsen","year":"2008","unstructured":"Reemtsen BL, Starnes VA (2008) Fenestrated right ventricular exclusion (Starnes\u2019 Procedure) for severe neonatal Ebstein\u2019s anomaly. Operative Tech Thorac Cardiovasc Surg 13:91\u2013100","journal-title":"Operative Techn Thorac Cardiovasc Surg"},{"key":"4208_CR21","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.xjtc.2020.05.011","volume":"3","author":"JP Da Silva","year":"2020","unstructured":"Da Silva JP, Viegas M, Castro-Medina M, Da Fonseca Da Silva L (2020) The Da Silva cone operation after the Starnes procedure for Ebstein\u2019s anomaly: new surgical strategy and initial results. JTCVS Tech 3:281\u2013283","journal-title":"JTCVS Tech"},{"key":"4208_CR22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jtcvs.2024.04.018","volume":"168","author":"IE Konstantinov","year":"2024","unstructured":"Konstantinov IE, Chai P, Bacha E, Caldarone CA, Da Silva JP, Da Fonseca Da Silva L, Dearani J, Hornberger L, Knott-Craig C, Del Nido P, Qureshi M, Sarris G, Starnes V, Tsang V (2024) The American Association for Thoracic Surgery (AATS) 2024 expert consensus document: management of neonates and infants with Ebstein anomaly. J Thorac Cardiovasc Surg 168:311\u2013324","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-026-04208-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-026-04208-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-026-04208-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T09:22:20Z","timestamp":1772443340000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-026-04208-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":22,"alternative-id":["4208"],"URL":"https:\/\/doi.org\/10.1007\/s00246-026-04208-0","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"12 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Our study was approved by both the Boston Children\u2019s Hospital (BCH) IRB (P00046448) and Mass General Brigham (MGB) IRB (2023P003513). A waiver of informed consent was obtained. A data use agreement was obtained between the institutions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}