{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:41:46Z","timestamp":1773204106497,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100017304","name":"Glenrose Rehabilitation Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"DOI":"10.1007\/s00246-026-04220-4","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:17:16Z","timestamp":1773127036000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hand Grip Strength at 4.5 Years of Age After Complex Cardiac Surgery in Early Infancy"],"prefix":"10.1007","author":[{"given":"Fernanda","family":"de Marzio Pestana Martins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4583-707X","authenticated-orcid":false,"given":"Ari R.","family":"Joffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Calistrate-Petre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"River","family":"Bossert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Dinu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene M. T.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Complex Pediatric Therapies Follow-up Program","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"4220_CR1","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1017\/S1047951122003092","volume":"32","author":"CC Niedermeyer","year":"2022","unstructured":"Niedermeyer CC, Shizukuishi MLY, Schaan CW, Lukrafka JL (2022) Peripheral and respiratory muscle strength in children and adolescents with CHD: systematic review and meta-analysis. Cardiol Young 32:1728\u20131741. https:\/\/doi.org\/10.1017\/S1047951122003092","journal-title":"Cardiol Young"},{"key":"4220_CR2","doi-asserted-by":"publisher","unstructured":"Neidenbach RC, M\u00fcller J, Ewert P, Hager A (2016) Decreased hand-grip strength in adolescents and adults with congenital heart disease depending on cyanosis. Thorac Cardiovasc Surg 64(Suppl2). https:\/\/doi.org\/10.1055\/s-0036-1571911","DOI":"10.1055\/s-0036-1571911"},{"issue":"5","key":"4220_CR3","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.2106\/JBJS.G.00469","volume":"90","author":"HM Molenaar","year":"2008","unstructured":"Molenaar HM, Selles RW, Zuidam JM, Stam HJ, Hovius SER, Slijper HP (2008) Age-specific reliability of two grip-strength dynamometers when used by children. J Bone Joint Surg Am 90(5):1053\u20131059. https:\/\/doi.org\/10.2106\/JBJS.G.00469","journal-title":"J Bone Joint Surg Am"},{"issue":"Suppl 2","key":"4220_CR4","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.21037\/cdt.2019.09.16","volume":"9","author":"RC Neidenbach","year":"2019","unstructured":"Neidenbach RC, Oberhoffer R, Pieper L, Freilinger S, Ewert P, Kaemmerer H, Nagdyman N, Hager A, M\u00fcller J (2019) The value of hand grip strength (HGS) as a diagnostic and prognostic biomarker in congenital heart disease. Cardiovasc Diagn Ther 9(Suppl 2):S187\u2013S197. https:\/\/doi.org\/10.21037\/cdt.2019.09.16","journal-title":"Cardiovasc Diagn Ther"},{"key":"4220_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s41043-024-00500-y","volume":"43","author":"R Vaishya","year":"2024","unstructured":"Vaishya R, Misra A, Vaish A, Ursino N, D\u2019Ambrosi R (2024) Hand grip strength as a proposed new vital sign of health: A narrative review of evidences. J Health Popul Nutr 43:7. https:\/\/doi.org\/10.1186\/s41043-024-00500-y","journal-title":"J Health Popul Nutr"},{"issue":"Suppl 1","key":"4220_CR6","doi-asserted-by":"publisher","first-page":"S45MP1","DOI":"10.1017\/S1047951119000489","volume":"29","author":"M Meyer","year":"2019","unstructured":"Meyer M, H\u00e4cker A, Weberruss H, Oberhoffer R, Ewert P, M\u00fcller J (2019) Reduced handgrip strength is associated with lower health related physical fitness in children with congenital heart disease. Cardiol Young 29(Suppl 1):S45MP1\u2013S45M12. https:\/\/doi.org\/10.1017\/S1047951119000489","journal-title":"Cardiol Young"},{"key":"4220_CR7","doi-asserted-by":"publisher","first-page":"e0027937","DOI":"10.1161\/JAHA.122.027937","volume":"12","author":"G Eshuis","year":"2023","unstructured":"Eshuis G, van Duinen H, Lelieveld OTHM, Hegeman AK, Willems TP, du Marchie Sarvaas GJ, Hepping AM, Berger RMF (2023) Decreased muscle strength in children with repaired tetralogy of Fallot: Relation with exercise capacity. J Am Heart Assoc 12:e0027937. https:\/\/doi.org\/10.1161\/JAHA.122.027937","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"4220_CR8","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/children12040471","volume":"12","author":"F Z\u00e1rate-Osuna","year":"2025","unstructured":"Z\u00e1rate-Osuna F, Zapico AG, Gonz\u00e1lez-Gross M (2025) Handgrip strength in children and adolescents aged 3 to 16 years and residing in Spain: new reference values. Child (Basel) 12(4):471. https:\/\/doi.org\/10.3390\/children12040471","journal-title":"Child (Basel)"},{"issue":"2","key":"4220_CR9","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1136\/archdischild-2020-319955","volume":"106","author":"M Meyer","year":"2021","unstructured":"Meyer M, Wang Y, Brudy L, H\u00e4cker AL, Schulz T, Weberruss H, Oberhoffer R, Ewert P, M\u00fcller J (2021) Impaired grip strength in children with congenital heart disease. Arch Dis Child 106(2):168\u2013174. https:\/\/doi.org\/10.1136\/archdischild-2020-319955","journal-title":"Arch Dis Child"},{"issue":"4","key":"4220_CR10","doi-asserted-by":"publisher","first-page":"318","DOI":"10.5014\/ajot.49.4.318","volume":"49","author":"L Link","year":"1995","unstructured":"Link L, Lukens S, Bush MA (1995) Spherical grip strength in children 3 to 6 years of age. Am J Occup Ther 49(4):318\u2013326. https:\/\/doi.org\/10.5014\/ajot.49.4.318","journal-title":"Am J Occup Ther"},{"key":"4220_CR11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s11999-009-0881-z","volume":"468","author":"HM Molenaar","year":"2010","unstructured":"Molenaar HM, Selles RW, Zuidam JM, Willemsen SP, Stam HJ, Hovius SER (2010) Growth diagrams for grip strength in children. Clin Orthop Relat Res 468:217\u2013223. https:\/\/doi.org\/10.1007\/s11999-009-0881-z","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"4220_CR12","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s40279-014-0281-8","volume":"45","author":"FB Ortega","year":"2015","unstructured":"Ortega FB, Cadenas-S\u00e1nchez C, S\u00e1nchez-Delgado G, Mora-Gonzalez J, Martinez-Tellez B, Artero EG, Castro-Pinero J, Labayen I, Chillon P, Lof M, Ruiz JR (2015) Systematic review and proposal of a field-based physical fitness test battery in preschool children: The PREFIT battery. Sports Med 45(4):533\u2013555. https:\/\/doi.org\/10.1007\/s40279-014-0281-8","journal-title":"Sports Med"},{"key":"4220_CR13","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3389\/fped.2018.00247","volume":"6","author":"J M\u00fcller","year":"2018","unstructured":"M\u00fcller J, R\u00f6ttgers L, Neidenbach RC, Oberhoffer R, Ewert P, Hager A (2018) Reduced handgrip strength in congenital heart disease with regard to the shunt procedure in infancy. Front Pediatr 6:247. https:\/\/doi.org\/10.3389\/fped.2018.00247","journal-title":"Front Pediatr"},{"issue":"1","key":"4220_CR14","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/jpn3.12406","volume":"80","author":"L Verbrugghe","year":"2025","unstructured":"Verbrugghe L, Larue A, Delcourt H, Vandenplas Y, Huysentruyt K (2025) Handgrip strength and health outcomes in hospitalized children or children with chronic disease: A systematic review. J Pediatr Gastroenterol Nutr 80(1):218\u2013237. https:\/\/doi.org\/10.1002\/jpn3.12406","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"10","key":"4220_CR15","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/jir.13092","volume":"67","author":"T Siyah","year":"2023","unstructured":"Siyah T, Saglam M, Yagli NV, Ertugrul I, Aykan HH, Karagoz T (2023) Investigation of cardiopulmonary parameters, motor development and muscle strength in children with Down syndrome with and without congenital heart disease. J Intellect Disabil Res 67(10):875\u2013885. https:\/\/doi.org\/10.1111\/jir.13092","journal-title":"J Intellect Disabil Res"},{"key":"4220_CR16","doi-asserted-by":"publisher","first-page":"965740","DOI":"10.4061\/2011\/965740","volume":"2011","author":"CMT Robertson","year":"2011","unstructured":"Robertson CMT, Sauve RS, Joffe AR, Alton GY, Moddemann DM, Blakley PM, Synnes AR, Dinu IA, Harder JR, Soni R, Bodani JP, Kakadekar AP, Dyck JD, Human DG, Ross DB, Rebeyka IM (2011) Registry and Follow-Up of Complex Pediatric Therapies Program of Western Canada: A Mechanism for Service, Audit, and Research after Life-Saving Therapies for Young Children. Cardiol Res Pract 2011:965740. https:\/\/doi.org\/10.4061\/2011\/965740","journal-title":"Cardiol Res Pract"},{"issue":"5","key":"4220_CR17","doi-asserted-by":"publisher","first-page":"841","DOI":"10.21873\/invivo.11147","volume":"31","author":"S Neumann","year":"2017","unstructured":"Neumann S, Kwisda S, Klotz MCM, Spies C, Volk HD, Wernecke KD (2017) Comparison of the grip strength using the Martin-Vigorimeter and the JAMAR-Dynamometer. Vivo 31(5):841\u2013846. https:\/\/doi.org\/10.21873\/invivo.11147","journal-title":"Vivo"},{"issue":"4","key":"4220_CR18","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3390\/jfmk9040274","volume":"9","author":"P Gr\u00e4nicher","year":"2024","unstructured":"Gr\u00e4nicher P, Maurer Y, Sporri J, Haller B, Swanenburg J, de Bie RA, Lenssen TAF, Scherr J (2024) Accuracy and reliability of grip strength measurements: A comparative device analysis. J Funct Morphol Kinesiol 9(4):274. https:\/\/doi.org\/10.3390\/jfmk9040274","journal-title":"J Funct Morphol Kinesiol"},{"key":"4220_CR19","volume-title":"Manual for the Preschool and Primary Scale of Intelligence","author":"D Wechsler","year":"2002","unstructured":"Wechsler D (2002) Manual for the Preschool and Primary Scale of Intelligence, 3rd edn. Psychological Corporation, San Antonio, Texas","edition":"3"},{"key":"4220_CR20","volume-title":"Wechsler Preschool and Primary Scale of Intelligence","author":"D Wechsler","year":"2012","unstructured":"Wechsler D (2012) Wechsler Preschool and Primary Scale of Intelligence, 4th edn. Psychological Corporation, San Antonio, Texas","edition":"4"},{"key":"4220_CR21","volume-title":"Manual of the Adaptive Behaviour Assessment System II","author":"P Harrison","year":"2003","unstructured":"Harrison P, Oakland T (2003) Manual of the Adaptive Behaviour Assessment System II. Harcourt Assessment Inc, San Antonio, Texas"},{"key":"4220_CR22","volume-title":"Adaptive Behavior Assessment System. (ABAS-3)","author":"P Harrison","year":"2015","unstructured":"Harrison P, Oakland T (2015) Adaptive Behavior Assessment System. (ABAS-3), 3rd edn. Pearson, San Antonio, Texas","edition":"3"},{"key":"4220_CR23","doi-asserted-by":"crossref","unstructured":"Henderson SE, Sugden DA, Barnett A (2007) Movement Assessment Battery for Children, Second Edition. MABC-2. Pearson Assessments","DOI":"10.1037\/t55281-000"},{"key":"4220_CR24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1755-618X.1987.tb00639.x","volume":"24","author":"BR Blishen","year":"1987","unstructured":"Blishen BR, Carroll WK, Moore C (1987) 1981 socioeconomic index for occupations in Canada. Canad Rev Soc 24:465\u2013488","journal-title":"Canad Rev Soc"},{"key":"4220_CR25","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1017\/S1047951124000398","volume":"34","author":"A Kavgac\u0131","year":"2024","unstructured":"Kavgac\u0131 A, Kula S, Berber Mara\u015fl\u0131 E, Zinnuro\u011flu M, \u00c7elik B, Terlemez S, Tunao\u011flu S, O\u011fuz D (2024) Evaluation of handgrip strength in children with pulmonary hypertension. Cardiol Young 34:1482\u20131486. https:\/\/doi.org\/10.1017\/S1047951124000398","journal-title":"Cardiol Young"},{"issue":"8","key":"4220_CR26","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1519\/JSC.0000000000002515","volume":"33","author":"MH Kocher","year":"2019","unstructured":"Kocher MH, Oba Y, Kimura IF, Stickley CD, Morgan CF, Hetzler RK (2019) Allometric grip strength norms for American children. J Strength Cond Res 33(8):2251\u20132261. https:\/\/doi.org\/10.1519\/JSC.0000000000002515","journal-title":"J Strength Cond Res"},{"key":"4220_CR27","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/1471-2474-13-176","volume":"13","author":"JY Hogrel","year":"2012","unstructured":"Hogrel JY, Decostre V, Alberti C, Canal A, Ollivier G, Josserand E, Taouil I, Simon D (2012) Stature is an essential predictor of muscle strength in children. BMC Musculoskelet Disord 13:176. https:\/\/doi.org\/10.1186\/1471-2474-13-176","journal-title":"BMC Musculoskelet Disord"},{"issue":"4","key":"4220_CR28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1836-9553(13)70202-9","volume":"59","author":"JJW Ploegmakers","year":"2013","unstructured":"Ploegmakers JJW, Hepping AM, Geertzen JHB, Bulstra SK, Stevens M (2013) Grip strength is strongly associated with height, weight and gender in childhood: a cross-sectional study of 2241 children and adolescents providing reference values. J Physiother 59(4):255\u2013261. https:\/\/doi.org\/10.1016\/S1836-9553(13)70202-9","journal-title":"J Physiother"},{"issue":"9","key":"4220_CR29","doi-asserted-by":"publisher","first-page":"5189","DOI":"10.1016\/j.clnu.2021.08.005","volume":"40","author":"S McKirdy","year":"2021","unstructured":"McKirdy S, Nichols B, Williamson S, Gerasimidis K (2021) Handgrip strength as a surrogate marker of lean mass and risk of malnutrition in paediatric patients. Clin Nutr 40(9):5189\u20135195. https:\/\/doi.org\/10.1016\/j.clnu.2021.08.005","journal-title":"Clin Nutr"},{"issue":"1","key":"4220_CR30","doi-asserted-by":"publisher","first-page":"2298474","DOI":"10.1080\/03014460.2023.2298474","volume":"51","author":"CM Avitabile","year":"2024","unstructured":"Avitabile CM, Weber DR, Zemel BS (2024) Paediatric dominant and non-dominant handgrip reference curves and the association with body composition. Ann Hum Biol 51(1):2298474. https:\/\/doi.org\/10.1080\/03014460.2023.2298474","journal-title":"Ann Hum Biol"},{"issue":"2","key":"4220_CR31","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1017\/S204017441100081X","volume":"3","author":"R Dodds","year":"2012","unstructured":"Dodds R, Macdonald-Wallis C, Kapasi T, Sayer AA, Robinson S, Godfrey K, Cooper C, Harvey N, Inskip H (2012) Grip strength at 4 years in relation to birth weight. J Dev Orig Health Dis 3(2):111\u2013115. https:\/\/doi.org\/10.1017\/S204017441100081X","journal-title":"J Dev Orig Health Dis"},{"issue":"1 Suppl","key":"4220_CR32","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1016\/j.ajog.2021.11.129","volume":"226","author":"AT Tita","year":"2022","unstructured":"Tita AT, Chen C, Grantz K, Grobman WA, Sciscione A, Skupski D, Palomares K, Vena JE, Newman R (2022) Neurodevelopmental outcomes of children born small-for-gestation and large-for-gestation compared with appropriate-for-gestation. Am J Obstet Gynecol 226(1 Suppl):S62\u2013S63. https:\/\/doi.org\/10.1016\/j.ajog.2021.11.129","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"4220_CR33","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1017\/S2040174410000309","volume":"1","author":"JG Barr","year":"2010","unstructured":"Barr JG, Veena SR, Kiran KN, Wills AK, Winder NR, Kehoe S, Fall CHD, Sayer AAS, Krishnaveni GV (2010) The relationship of birthweight, muscle size at birth and post-natal growth to grip strength in 9-year-old Indian children: findings from the Mysore Parthenon study. J Dev Orig Health Dis 1(5):329\u2013337. https:\/\/doi.org\/10.1017\/S2040174410000309","journal-title":"J Dev Orig Health Dis"},{"issue":"12","key":"4220_CR34","doi-asserted-by":"publisher","first-page":"e33465","DOI":"10.1016\/j.heliyon.2024.e33465","volume":"10","author":"Y Wang","year":"2024","unstructured":"Wang Y, Zhang Y, Zhao W, Cai W, Zhao C (2024) Exploring the association between grip strength and adverse pregnancy and perinatal outcomes: a Mendelian randomization study. Heliyon 10(12):e33465. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e33465","journal-title":"Heliyon"},{"issue":"8","key":"4220_CR35","doi-asserted-by":"publisher","first-page":"e001954","DOI":"10.1161\/JAHA.115.001954","volume":"4","author":"N Sidhu","year":"2015","unstructured":"Sidhu N, Joffe AR, Doughty P, Vatanpour S, Dinu I, Alton G, Acton B, Robertson CMT (2015) Sepsis after cardiac surgery early in infancy and adverse 4.5-year neurocognitive outcomes. J Am Heart Assoc 4(8):e001954. https:\/\/doi.org\/10.1161\/JAHA.115.001954","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"4220_CR36","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1017\/S104795112200261X","volume":"33","author":"GK Khaira","year":"2023","unstructured":"Khaira GK, Joffe AR, Guerra GG, Matenchuk BA, Dinu I, Bond G, Alaklabi M, Robertson CMT, Sivarajan VB (2023) A complicated Glenn procedure: risk factors and association with adverse long-term neurodevelopmental and functional outcomes. Cardiol Young 33(9):1536\u20131543. https:\/\/doi.org\/10.1017\/S104795112200261X","journal-title":"Cardiol Young"},{"key":"4220_CR37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40560-018-0326-4","volume":"6","author":"GA Kuraim","year":"2018","unstructured":"Kuraim GA, Garros D, Ryerson L, Moradi F, Dinu IA, Garcia Guerra G, Moddemann D, Bond GY, Robertson CMT, Joffe AR (2018) Predictors and outcomes of early postoperative veno-arterial extracorporeal membrane oxygenation following infant cardiac surgery. J Intensive Care 6:56. https:\/\/doi.org\/10.1186\/s40560-018-0326-4","journal-title":"J Intensive Care"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-026-04220-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00246-026-04220-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-026-04220-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:17:19Z","timestamp":1773127039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00246-026-04220-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":37,"alternative-id":["4220"],"URL":"https:\/\/doi.org\/10.1007\/s00246-026-04220-4","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"assertion":[{"value":"14 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}