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Social determinants of health (SDOH) and environmental factors influence brain growth in other populations and likely play a neurodevelopmental role in CHD. This study evaluated the influence of SDOH and environmental factors on fetal and neonatal brain volume, growth, and risk of brain injury in CHD. This prospective single-center longitudinal cohort study enrolled fetuses with severe CHD to undergo third-trimester fetal and preoperative brain MRIs. Controls underwent third-trimester brain MRIs. Participants completed SDOH and environmental exposure surveys. Fetal and neonatal brain volumes, brain growth, and presence of white matter injury (WMI) were assessed. 57 CHD patients and 24 controls were enrolled, resulting in 33 fetal and 44 neonatal MRIs in the CHD group and 21 fetal control MRIs. Several SDOH and environmental factors, including maternal smoking, were associated with smaller brain volume and slower brain growth in CHD but not in controls. With CHD, repeated-measures analysis showed smaller fetal brain volume (coeff: \u2212 13.3, 95% CI \u2212 25.5, \u2212 1.1,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) and slower growth (coeff: \u2212 2.5, 95% CI \u2212 5.0, \u2212 0.07,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04) with exposure to any risk factor. Patients with moderate to severe WMI had significantly lower mean COI scores compared to those with no or minimal WMI (58.28 vs. 37.28,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), but lost significance when adjusted for GA. SDOH and environmental exposures influence fetal brain growth and preoperative brain injury risk in CHD. These results highlight additive environmental prenatal risks which may be amenable to early intervention.\n                  <\/jats:p>","DOI":"10.1007\/s00246-026-04308-x","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:20:59Z","timestamp":1779708059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2777-5836","authenticated-orcid":false,"given":"Lesje","family":"DeRose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3689-1453","authenticated-orcid":false,"given":"Megan","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3141-5738","authenticated-orcid":false,"given":"Elizabeth","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Luna","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9397-6198","authenticated-orcid":false,"given":"Flora Nu\u00f1ez","family":"Gallegos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-160X","authenticated-orcid":false,"given":"Martina","family":"Steurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-4235","authenticated-orcid":false,"given":"Duan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-364X","authenticated-orcid":false,"given":"Patrick","family":"McQuillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-544X","authenticated-orcid":false,"given":"Shabnam","family":"Peyvandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"4308_CR1","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1542\/peds.2014-3825","volume":"135","author":"JW Gaynor","year":"2015","unstructured":"Gaynor JW, Stopp C, Wypij D et al (2015) Neurodevelopmental outcomes after cardiac surgery in infancy. 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