{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:03:26Z","timestamp":1784106206211,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001774","name":"The University of Sydney","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"abstract":"Abstract<\/jats:title>\n \n The right atrium (RA) and atrialised RV (aRV) may be important in determining exercise capacity in Ebstein anomaly (EA). We performed exercise testing and resting\/exercise cardiac magnetic resonance imaging (CMRI) to examine associations between RA and aRV and left heart volumes, cardiac index and exercise capacity (%VO\n 2max<\/jats:sub>\n ).\u00a0In 13 un-operated EA patients (median age 13.5 years), indexed end-diastolic volumes were calculated from resting CMRI; right atrium (RAi), atrialised RV (aRVi), functional RV (fRVEDVi), left atrium (LAi) and left ventricle (LVEDVi). Systolic (SCR\n sys<\/jats:sub>\n ) and diastolic (SCR\n dias<\/jats:sub>\n ) septal curvature were measured. Pulmonary artery and aortic flow were measured at rest and peak exercise, and cardiac index (CI) calculated. CI\n ex<\/jats:sub>\n was strongly positively associated with %VO\n 2max<\/jats:sub>\n (\n r<\/jats:italic>\n \u2009=\u20090.74,\n p<\/jats:italic>\n \u2009=\u20090.01). RAi and aRVi, but not fRVEDVi, were negatively associated with %VO\n 2max<\/jats:sub>\n , CI\n rest<\/jats:sub>\n and CI\n ex<\/jats:sub>\n . fRVEF was positively associated with %VO\n 2max<\/jats:sub>\n , CI\n rest<\/jats:sub>\n and CI\n ex<\/jats:sub>\n . LAi, LVEDVi and LVEF were associated with %VO\n 2max<\/jats:sub>\n , CI\n rest<\/jats:sub>\n and CI\n ex<\/jats:sub>\n . SCR\n dias<\/jats:sub>\n was strongly negatively associated with aRV\n i<\/jats:sub>\n (\n r<\/jats:italic>\n =-0.89,\n p<\/jats:italic>\n \u2009<\u20090.01) and RA\n i<\/jats:sub>\n (\n r<\/jats:italic>\n =-0.73,\n p<\/jats:italic>\n \u2009<\u20090.01) but not with fRVEDV\n i<\/jats:sub>\n (\n r<\/jats:italic>\n =-0.34,\n p<\/jats:italic>\n \u2009=\u20090.28). In multivariable models LVEDVi had the most significant influence on %VO\n 2max<\/jats:sub>\n , CI\n rest<\/jats:sub>\n and CI\n ex<\/jats:sub>\n .\u00a0In EA, volumes of the true RA and aRV but not fRV are associated with exercise capacity and cardiac output at rest and on exercise. Maintaining LV diastolic volume is a key determinant of exercise capacity in EA.\n <\/jats:p>","DOI":"10.1007\/s00246-026-04371-4","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:04:23Z","timestamp":1784102663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Right Atrium and Atrialised Right Ventricle are Associated with Cardiac Output During Exercise in Patients with Ebstein Anomaly of the Tricuspid Valve"],"prefix":"10.1007","author":[{"given":"Ganesh Kumar","family":"Gnanappa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Luxford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dryburgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Celermajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Puranik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Laohachai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Ayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"4371_CR1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0002-9149(85)91175-0","volume":"56","author":"G Barber","year":"1985","unstructured":"Barber G, Danielson GK, Heise CT et al (1985) Cardiorespiratory response to exercise in Ebstein\u2019s anomaly. 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