{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:09:53Z","timestamp":1780358993761,"version":"3.54.1"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T00:00:00Z","timestamp":1187654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T00:00:00Z","timestamp":1187654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1007\/s00247-007-0567-1","type":"journal-article","created":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T07:15:19Z","timestamp":1187594119000},"page":"1191-1200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["MRI evaluation of tissue iron burden in patients with \u03b2-thalassaemia major"],"prefix":"10.1007","volume":"37","author":[{"given":"Maria I.","family":"Argyropoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loukas","family":"Astrakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,8,21]]},"reference":[{"key":"567_CR1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJMra050436","volume":"353","author":"D Rund","year":"2005","unstructured":"Rund D, Rachmilewitz E (2005) Beta-thalassemia. N Engl J Med 353:1135\u20131146","journal-title":"N Engl J Med"},{"key":"567_CR2","first-page":"95","volume":"60","author":"BG Forget","year":"1993","unstructured":"Forget BG (1993) The pathophysiology and molecular genetics of beta thalassemia. Mt Sinai J Med 60:95\u2013103","journal-title":"Mt Sinai J Med"},{"key":"567_CR3","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1182\/blood.V96.7.2606.h8002606_2606_2612","volume":"96","author":"P Pootrakul","year":"2000","unstructured":"Pootrakul P, Sirankapracha P, Hemsorach S et al (2000) A correlation of erythrokinetics, ineffective erythropoiesis, and erythroid precursor apoptosis in Thai patients with thalassemia. Blood 96:2606\u20132612","journal-title":"Blood"},{"key":"567_CR4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","volume":"117","author":"MW Hentze","year":"2004","unstructured":"Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285\u2013297","journal-title":"Cell"},{"key":"567_CR5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/nbm.903","volume":"17","author":"Y Gossuin","year":"2004","unstructured":"Gossuin Y, Muller RN, Gillis P (2004) Relaxation induced by ferritin: a better understanding for an improved MRI iron quantification. NMR Biomed 17:427\u2013432","journal-title":"NMR Biomed"},{"key":"567_CR6","first-page":"77","volume":"120","author":"GM Brittenham","year":"2005","unstructured":"Brittenham GM (2005) Iron balance in the red blood cell donor. Dev Biol (Basel) 120:77\u201382","journal-title":"Dev Biol (Basel)"},{"key":"567_CR7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1053\/beha.2002.0214","volume":"15","author":"JB Porter","year":"2002","unstructured":"Porter JB, Davis BA (2002) Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassaemia. Best Pract Res Clin Haematol 15:329\u2013368","journal-title":"Best Pract Res Clin Haematol"},{"key":"567_CR8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/01.moh.0000152631.63469.07","volume":"12","author":"MJ Cunningham","year":"2005","unstructured":"Cunningham MJ, Nathan DG (2005) New developments in iron chelators. Curr Opin Hematol 12:129\u2013134","journal-title":"Curr Opin Hematol"},{"key":"567_CR9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1196\/annals.1345.015","volume":"1054","author":"C Hershko","year":"2005","unstructured":"Hershko C, Link G, Konijn AM et al (2005) Objectives and mechanism of iron chelation therapy. Ann N Y Acad Sci 1054:124\u2013135","journal-title":"Ann N Y Acad Sci"},{"key":"567_CR10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ajh.10348","volume":"73","author":"TB Chaston","year":"2003","unstructured":"Chaston TB, Richardson DR (2003) Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity. Am J Hematol 73:200\u2013210","journal-title":"Am J Hematol"},{"key":"567_CR11","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","volume":"99","author":"FM Torti","year":"2002","unstructured":"Torti FM, Torti SV (2002) Regulation of ferritin genes and protein. Blood 99:3505\u20133516","journal-title":"Blood"},{"key":"567_CR12","first-page":"703","volume":"42","author":"RJ Rothman","year":"1992","unstructured":"Rothman RJ, Serroni A, Farber JL (1992) Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury. Mol Pharmacol 42:703\u2013710","journal-title":"Mol Pharmacol"},{"key":"567_CR13","first-page":"35","volume":"309","author":"V Gabutti","year":"1989","unstructured":"Gabutti V, Piga A, Sacchetti L et al (1989) Quality of life and life expectancy in thalassemic patients with complications. Prog Clin Biol Res 309:35\u201341","journal-title":"Prog Clin Biol Res"},{"key":"567_CR14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2141.1986.tb02930.x","volume":"62","author":"K Saito","year":"1986","unstructured":"Saito K, Nishisato T, Grasso JA et al (1986) Interaction of transferrin with iron-loaded rat peritoneal macrophages. Br J Haematol 62:275\u2013286","journal-title":"Br J Haematol"},{"key":"567_CR15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1196\/annals.1345.018","volume":"1054","author":"JB Porter","year":"2005","unstructured":"Porter JB, Rafique R, Srichairatanakool S et al (2005) Recent insights into interactions of deferoxamine with cellular and plasma iron pools: Implications for clinical use. Ann N Y Acad Sci 1054:155\u2013168","journal-title":"Ann N Y Acad Sci"},{"key":"567_CR16","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1182\/blood.V86.5.2008.bloodjournal8652008","volume":"86","author":"O Shalev","year":"1995","unstructured":"Shalev O, Repka T, Goldfarb A et al (1995) Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo. Blood 86:2008\u20132013","journal-title":"Blood"},{"key":"567_CR17","first-page":"398","volume":"80","author":"P Mazza","year":"1995","unstructured":"Mazza P, Giua R, De Marco S et al (1995) Iron overload in thalassemia: comparative analysis of magnetic resonance imaging, serum ferritin and iron content of the liver. Haematologica 80:398\u2013404","journal-title":"Haematologica"},{"key":"567_CR18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0730-725X(95)00041-E","volume":"13","author":"OG Papakonstantinou","year":"1995","unstructured":"Papakonstantinou OG, Maris TG, Kostaridou V et al (1995) Assessment of liver iron overload by T2-quantitative magnetic resonance imaging: correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosis. Magn Reson Imaging 13:967\u2013977","journal-title":"Magn Reson Imaging"},{"key":"567_CR19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0140-6736(04)15436-6","volume":"363","author":"Y Gandon","year":"2004","unstructured":"Gandon Y, Olivie D, Guyader D et al (2004) Non-invasive assessment of hepatic iron stores by MRI. Lancet 363:357\u2013362","journal-title":"Lancet"},{"issue":"Suppl 1","key":"567_CR20","first-page":"18","volume":"12","author":"A Locasciulli","year":"1993","unstructured":"Locasciulli A, Monguzzi W, Tornotti G et al (1993) Hepatitis C virus infection and liver disease in children with thalassemia. Bone Marrow Transplant 12 [Suppl 1]:18\u201320","journal-title":"Bone Marrow Transplant"},{"key":"567_CR21","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1056\/NEJM199506013322202","volume":"332","author":"MJ Tong","year":"1995","unstructured":"Tong MJ, el-Farra NS, Reikes AR et al (1995) Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 332:1463\u20131466","journal-title":"N Engl J Med"},{"key":"567_CR22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1196\/annals.1345.045","volume":"1054","author":"DJ Pennell","year":"2005","unstructured":"Pennell DJ (2005) T2* magnetic resonance and myocardial iron in thalassemia. Ann N Y Acad Sci 1054:373\u2013378","journal-title":"Ann N Y Acad Sci"},{"key":"567_CR23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2141.1990.tb02596.x","volume":"74","author":"JP Kaltwasser","year":"1990","unstructured":"Kaltwasser JP, Gottschalk R, Schalk KP et al (1990) Non-invasive quantitation of liver iron-overload by magnetic resonance imaging. Br J Haematol 74:360\u2013363","journal-title":"Br J Haematol"},{"key":"567_CR24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF01888728","volume":"15","author":"JL Chezmar","year":"1990","unstructured":"Chezmar JL, Nelson RC, Malko JA et al (1990) Hepatic iron overload: diagnosis and quantification by noninvasive imaging. Gastrointest Radiol 15:27\u201331","journal-title":"Gastrointest Radiol"},{"key":"567_CR25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0016-5085(90)90629-F","volume":"99","author":"HL Bonkovsky","year":"1990","unstructured":"Bonkovsky HL, Slaker DP, Bills EB et al (1990) Usefulness and limitations of laboratory and hepatic imaging studies in iron-storage disease. Gastroenterology 99:1079\u20131091","journal-title":"Gastroenterology"},{"key":"567_CR26","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0168-8278(92)90060-3","volume":"15","author":"D Guyader","year":"1992","unstructured":"Guyader D, Gandon Y, Robert JY et al (1992) Magnetic resonance imaging and assessment of liver iron content in genetic hemochromatosis. J Hepatol 15:304\u2013308","journal-title":"J Hepatol"},{"key":"567_CR27","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.2214\/ajr.168.5.9129412","volume":"168","author":"O Ernst","year":"1997","unstructured":"Ernst O, Sergent G, Bonvarlet P et al (1997) Hepatic iron overload: diagnosis and quantification with MR imaging. AJR 168:1205\u20131208","journal-title":"AJR"},{"key":"567_CR28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/01.mph.0000212915.22265.3b","volume":"28","author":"A Christoforidis","year":"2006","unstructured":"Christoforidis A, Haritandi A, Tsitouridis I et al (2006) Correlative study of iron accumulation in liver, myocardium, and pituitary assessed with MRI in young thalassemic patients. J Pediatr Hematol Oncol 28:311\u2013315","journal-title":"J Pediatr Hematol Oncol"},{"key":"567_CR29","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/00004728-200211000-00023","volume":"26","author":"MJ Kim","year":"2002","unstructured":"Kim MJ, Mitchell DG, Ito K et al (2002) Hepatic iron deposition on magnetic resonance imaging: correlation with inflammatory activity. J Comput Assist Tomogr 26:988\u2013993","journal-title":"J Comput Assist Tomogr"},{"key":"567_CR30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1148\/radiology.193.2.7972774","volume":"193","author":"Y Gandon","year":"1994","unstructured":"Gandon Y, Guyader D, Heautot JF et al (1994) Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging. Radiology 193:533\u2013538","journal-title":"Radiology"},{"key":"567_CR31","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/hep.1840170609","volume":"17","author":"E Rocchi","year":"1993","unstructured":"Rocchi E, Cassanelli M, Borghi A et al (1993) Magnetic resonance imaging and different levels of iron overload in chronic liver disease. Hepatology 17:997\u20131002","journal-title":"Hepatology"},{"key":"567_CR32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1148\/radiology.179.2.2014276","volume":"179","author":"JM Gomori","year":"1991","unstructured":"Gomori JM, Horev G, Tamary H et al (1991) Hepatic iron overload: quantitative MR imaging. Radiology 179:367\u2013369","journal-title":"Radiology"},{"key":"567_CR33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/mrm.1910290406","volume":"29","author":"G Bartzokis","year":"1993","unstructured":"Bartzokis G, Aravagiri M, Oldendorf WH et al (1993) Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores. Magn Reson Med 29:459\u2013464","journal-title":"Magn Reson Med"},{"key":"567_CR34","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1148\/radiology.210.3.r99fe41759","volume":"210","author":"N Gelman","year":"1999","unstructured":"Gelman N, Gorell JM, Barker PB et al (1999) MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. Radiology 210:759\u2013767","journal-title":"Radiology"},{"key":"567_CR35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jmri.20467","volume":"23","author":"NR Ghugre","year":"2006","unstructured":"Ghugre NR, Enriquez CM, Coates TD et al (2006) Improved R2* measurements in myocardial iron overload. J Magn Reson Imaging 23:9\u201316","journal-title":"J Magn Reson Imaging"},{"key":"567_CR36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0609.2005.00474.x","volume":"75","author":"SI Mavrogeni","year":"2005","unstructured":"Mavrogeni SI, Markussis V, Kaklamanis L et al (2005) A comparison of magnetic resonance imaging and cardiac biopsy in the evaluation of heart iron overload in patients with beta-thalassemia major. Eur J Haematol 75:241\u2013247","journal-title":"Eur J Haematol"},{"key":"567_CR37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1600-0609.2006.00770.x","volume":"78","author":"A Aessopos","year":"2007","unstructured":"Aessopos A, Giakoumis A, Fragodimitri C et al (2007) Correlation of echocardiography parameters with cardiac magnetic resonance imaging in transfusion-dependent thalassaemia major. Eur J Haematol 78:58\u201365","journal-title":"Eur J Haematol"},{"key":"567_CR38","doi-asserted-by":"crossref","first-page":"f43","DOI":"10.1161\/CIRCULATIONAHA.105.618942","volume":"113","author":"D Pennell","year":"2006","unstructured":"Pennell D (2006) MRI and iron-overload cardiomyopathy in thalassaemia. Circulation 113:f43\u201344","journal-title":"Circulation"},{"key":"567_CR39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jmri.20489","volume":"23","author":"E Alexopoulou","year":"2006","unstructured":"Alexopoulou E, Stripeli F, Baras P et al (2006) R2 relaxometry with MRI for the quantification of tissue iron overload in beta-thalassemic patients. J Magn Reson Imaging 23:163\u2013170","journal-title":"J Magn Reson Imaging"},{"key":"567_CR40","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-2141.2004.05104.x","volume":"126","author":"E Voskaridou","year":"2004","unstructured":"Voskaridou E, Douskou M, Terpos E et al (2004) Magnetic resonance imaging in the evaluation of iron overload in patients with beta thalassaemia and sickle cell disease. Br J Haematol 126:736\u2013742","journal-title":"Br J Haematol"},{"key":"567_CR41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/mrm.20510","volume":"54","author":"AA Carneiro","year":"2005","unstructured":"Carneiro AA, Fernandes JP, de Araujo DB et al (2005) Liver iron concentration evaluated by two magnetic methods: magnetic resonance imaging and magnetic susceptometry. Magn Reson Med 54:122\u2013128","journal-title":"Magn Reson Med"},{"key":"567_CR42","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jmri.20566","volume":"23","author":"A Pepe","year":"2006","unstructured":"Pepe A, Positano V, Santarelli MF et al (2006) Multislice multiecho T2* cardiovascular magnetic resonance for detection of the heterogeneous distribution of myocardial iron overload. J Magn Reson Imaging 23:662\u2013668","journal-title":"J Magn Reson Imaging"},{"key":"567_CR43","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2214\/ajr.175.6.1751567","volume":"175","author":"MI Argyropoulou","year":"2000","unstructured":"Argyropoulou MI, Metafratzi Z, Kiortsis DN et al (2000) T2 relaxation rate as an index of pituitary iron overload in patients with beta-thalassemia major. AJR 175:1567\u20131569","journal-title":"AJR"},{"key":"567_CR44","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1182\/blood-2004-01-0177","volume":"105","author":"TG St Pierre","year":"2005","unstructured":"St Pierre TG, Clark PR, Chua-anusorn W et al (2005) Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 105:855\u2013861","journal-title":"Blood"},{"key":"567_CR45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood-2002-06-1723","volume":"101","author":"GM Brittenham","year":"2003","unstructured":"Brittenham GM, Badman DG (2003) Noninvasive measurement of iron: report of an NIDDK workshop. Blood 101:15\u201319","journal-title":"Blood"},{"key":"567_CR46","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/jmri.10080","volume":"15","author":"ZJ Wang","year":"2002","unstructured":"Wang ZJ, Haselgrove JC, Martin MB et al (2002) Evaluation of iron overload by single voxel MRS measurement of liver T2. J Magn Reson Imaging 15:395\u2013400","journal-title":"J Magn Reson Imaging"},{"key":"567_CR47","first-page":"835","volume":"46","author":"J Vymazal","year":"2000","unstructured":"Vymazal J, Urgosik D, Bulte JW (2000) Differentiation between hemosiderin- and ferritin-bound brain iron using nuclear magnetic resonance and magnetic resonance imaging. Cell Mol Biol (Noisy-le-grand) 46:835\u2013842","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"567_CR48","first-page":"221","volume-title":"Hydration processes in biology","author":"B Halle","year":"1999","unstructured":"Halle B (1999) Water in biological systems: the NMR picture. In: Bellisent-Funel M-C (ed) Hydration processes in biology. IOS Press, Amsterdam, pp 221\u2013232"},{"key":"567_CR49","first-page":"85","volume":"412","author":"G Tian","year":"1997","unstructured":"Tian G, Shen J, Su S et al (1997) Evaluation of hydroxyethyl-starch-ferrioxamine as an intravascular MR contrast agent for assessment of myocardial perfusion. Acta Radiol Suppl 412:85\u201390","journal-title":"Acta Radiol Suppl"},{"key":"567_CR50","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1063\/1.1743771","volume":"25","author":"N Bloembergen","year":"1957","unstructured":"Bloembergen N (1957) Proton relaxation time in paramagnetic solutions. J Chem Phys 25:572\u2013573","journal-title":"J Chem Phys"},{"key":"567_CR51","first-page":"58","volume":"19","author":"M Gueron","year":"1975","unstructured":"Gueron M (1975) Nuclear relaxation in macromolecules by paramagnetic ions: a novel mechanism. J Magn Reson 19:58\u201366","journal-title":"J Magn Reson"},{"key":"567_CR52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/jmre.1998.1691","volume":"137","author":"P Gillis","year":"1999","unstructured":"Gillis P, Roch A, Brooks RA (1999) Corrected equations for susceptibility-induced T2-shortening. J Magn Reson 137:402\u2013407","journal-title":"J Magn Reson"},{"key":"567_CR53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/mrm.1910050404","volume":"5","author":"P Gillis","year":"1987","unstructured":"Gillis P, Koenig SH (1987) Transverse relaxation of solvent protons induced by magnetized spheres: application to ferritin, erythrocytes, and magnetite. Magn Reson Med 5:323\u2013345","journal-title":"Magn Reson Med"},{"key":"567_CR54","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/mrm.10059","volume":"47","author":"P Gillis","year":"2002","unstructured":"Gillis P, Moiny F, Brooks RA (2002) On T(2)-shortening by strongly magnetized spheres: a partial refocusing model. Magn Reson Med 47:257\u2013263","journal-title":"Magn Reson Med"},{"key":"567_CR55","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/mrm.10316","volume":"48","author":"Y Gossuin","year":"2002","unstructured":"Gossuin Y, Roch A, Muller RN et al (2002) Anomalous nuclear magnetic relaxation of aqueous solutions of ferritin: an unprecedented first-order mechanism. Magn Reson Med 48:959\u2013964","journal-title":"Magn Reson Med"},{"key":"567_CR56","doi-asserted-by":"crossref","first-page":"9380","DOI":"10.1021\/jp9712213","volume":"101","author":"V Denisov","year":"1997","unstructured":"Denisov V, Venu K, Peters J et al (1997) Orientational disorder and entropy of water in protein cavities. J Phys Chem B 101:9380\u20139389","journal-title":"J Phys Chem B"},{"key":"567_CR57","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/mrm.1216","volume":"46","author":"Y Gossuin","year":"2001","unstructured":"Gossuin Y, Roch A, Lo Bue F et al (2001) Nuclear magnetic relaxation dispersion of ferritin and ferritin-like magnetic particle solutions: a pH-effect study. Magn Reson Med 46:476\u2013481","journal-title":"Magn Reson Med"},{"key":"567_CR58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00330-002-1421-3","volume":"13","author":"MI Argyropoulou","year":"2003","unstructured":"Argyropoulou MI, Kiortsis DN, Efremidis SC (2003) MRI of the liver and the pituitary gland in patients with beta-thalassemia major: does hepatic siderosis predict pituitary iron deposition? Eur Radiol 13:12\u201316","journal-title":"Eur Radiol"},{"key":"567_CR59","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s00330-006-0504-y","volume":"17","author":"EE Drakonaki","year":"2007","unstructured":"Drakonaki EE, Maris TG, Papadakis A et al (2007) Bone marrow changes in beta-thalassemia major: quantitative MR imaging findings and correlation with iron stores. Eur Radiol 17:2079\u20132087","journal-title":"Eur Radiol"},{"key":"567_CR60","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2214\/ajr.185.1.01850219","volume":"185","author":"O Papakonstantinou","year":"2005","unstructured":"Papakonstantinou O, Maris TG, Kostaridou S et al (2005) Abdominal lymphadenopathy in beta-thalassemia: MRI features and correlation with liver iron overload and posttransfusion chronic hepatitis C. AJR 185:219\u2013224","journal-title":"AJR"},{"key":"567_CR61","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00330-006-0507-8","volume":"17","author":"O Papakonstantinou","year":"2006","unstructured":"Papakonstantinou O, Ladis V, Kostaridou S et al (2006) The pancreas in beta-thalassemia major: MR imaging features and correlation with iron stores and glucose disturbances. Eur Radiol 17:1535\u20131543","journal-title":"Eur Radiol"},{"key":"567_CR62","doi-asserted-by":"publisher","unstructured":"Papakonstantinou O, Drakonaki EE, Maris T et al (2006) MR imaging of spleen in beta-thalassemia major. Abdom Imaging. DOI 10.1007\/s00261-006-9138-4","DOI":"10.1007\/s00261-006-9138-4"},{"key":"567_CR63","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1196\/annals.1345.046","volume":"1054","author":"TG St Pierre","year":"2005","unstructured":"St Pierre TG, Clark PR, Chua-Anusorn W (2005) Measurement and mapping of liver iron concentrations using magnetic resonance imaging. Ann N Y Acad Sci 1054:379\u2013385","journal-title":"Ann N Y Acad Sci"},{"key":"567_CR64","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jmri.10306","volume":"17","author":"A Fenzi","year":"2003","unstructured":"Fenzi A, Bortolazzi M, Marzola P (2003) Comparison between signal-to-noise ratio, liver-to-muscle ratio, and 1\/T2 for the noninvasive assessment of liver iron content by MRI. J Magn Reson Imaging 17:589\u2013592","journal-title":"J Magn Reson Imaging"},{"key":"567_CR65","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1103\/PhysRev.94.630","volume":"94","author":"HY Carr","year":"1954","unstructured":"Carr HY, Purcell EM (1954) Effects of diffusion on free precession in nuclear magnetic resonance experiments. Phys Rev 94:630\u2013638","journal-title":"Phys Rev"},{"key":"567_CR66","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1063\/1.1716296","volume":"29","author":"S Meiboom","year":"1958","unstructured":"Meiboom S, Gill D (1958) Modified spin-echo method for measuring nuclear relaxation times. Rev Sci Instrum 29:688\u2013691","journal-title":"Rev Sci Instrum"},{"key":"567_CR67","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/mrm.1910050602","volume":"5","author":"JJ In den Kleef","year":"1987","unstructured":"In den Kleef JJ, Cuppen JJ (1987) RLSQ: T1, T2, and rho calculations, combining ratios and least squares. Magn Reson Med 5:513\u2013524","journal-title":"Magn Reson Med"},{"key":"567_CR68","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","volume":"22","author":"LJ Anderson","year":"2001","unstructured":"Anderson LJ, Holden S, Davis B et al (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171\u20132179","journal-title":"Eur Heart J"},{"key":"567_CR69","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1182\/blood-2003-06-1919","volume":"103","author":"JC Wood","year":"2004","unstructured":"Wood JC, Tyszka JM, Carson S et al (2004) Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood 103:1934\u20131936","journal-title":"Blood"},{"key":"567_CR70","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1182\/blood-2002-09-2754","volume":"101","author":"PD Jensen","year":"2003","unstructured":"Jensen PD, Jensen FT, Christensen T et al (2003) Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: indication of close relation between myocardial iron content and chelatable iron pool. Blood 101:4632\u20134639","journal-title":"Blood"},{"key":"567_CR71","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/jmri.10396","volume":"18","author":"MA Westwood","year":"2003","unstructured":"Westwood MA, Anderson LJ, Firmin DN et al (2003) Interscanner reproducibility of cardiovascular magnetic resonance T2* measurements of tissue iron in thalassemia. J Magn Reson Imaging 18:616\u2013620","journal-title":"J Magn Reson Imaging"},{"key":"567_CR72","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1212\/WNL.45.6.1138","volume":"45","author":"JM Gorell","year":"1995","unstructured":"Gorell JM, Ordidge RJ, Brown GG et al (1995) Increased iron-related MRI contrast in the substantia nigra in Parkinson\u2019s disease. Neurology 45:1138\u20131143","journal-title":"Neurology"},{"key":"567_CR73","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/mrm.1910320309","volume":"32","author":"RJ Ordidge","year":"1994","unstructured":"Ordidge RJ, Gorell JM, Deniau JC et al (1994) Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med 32:335\u2013341","journal-title":"Magn Reson Med"},{"key":"567_CR74","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/(SICI)1522-2594(199904)41:4<686::AID-MRM6>3.0.CO;2-9","volume":"41","author":"CM Wacker","year":"1999","unstructured":"Wacker CM, Bock M, Hartlep AW et al (1999) Changes in myocardial oxygenation and perfusion under pharmacological stress with dipyridamole: assessment using T*2 and T1 measurements. Magn Reson Med 41:686\u2013695","journal-title":"Magn Reson Med"},{"key":"567_CR75","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0140-6736(03)12221-0","volume":"361","author":"TG St Pierre","year":"2003","unstructured":"St Pierre TG (2003) Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Lancet 361:182; author reply 183\u2013184","journal-title":"Lancet"},{"key":"567_CR76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<51::AID-MRM9>3.0.CO;2-G","volume":"41","author":"WR Bauer","year":"1999","unstructured":"Bauer WR, Nadler W, Bock M et al (1999) Theory of the bold effect in the capillary region: an analytical approach for the determination of T2 in the capillary network of myocardium. Magn Reson Med 41:51\u201362","journal-title":"Magn Reson Med"},{"key":"567_CR77","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00043426-199903000-00011","volume":"21","author":"O Papakonstantinou","year":"1999","unstructured":"Papakonstantinou O, Kostaridou S, Maris T et al (1999) Quantification of liver iron overload by T2 quantitative magnetic resonance imaging in thalassemia: impact of chronic hepatitis C on measurements. J Pediatr Hematol Oncol 21:142\u2013148","journal-title":"J Pediatr Hematol Oncol"},{"key":"567_CR78","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF01141308","volume":"4","author":"TG St Pierre","year":"1991","unstructured":"St Pierre TG, Tran KC, Webb J et al (1991) Organ-specific crystalline structures of ferritin cores in beta-thalassemia\/hemoglobin E. Biol Met 4:162\u2013165","journal-title":"Biol Met"},{"key":"567_CR79","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1196\/annals.1345.067","volume":"1054","author":"V Ladis","year":"2005","unstructured":"Ladis V, Chouliaras G, Berdousi H et al (2005) Longitudinal study of survival and causes of death in patients with thalassemia major in Greece. Ann N Y Acad Sci 1054:445\u2013450","journal-title":"Ann N Y Acad Sci"},{"key":"567_CR80","first-page":"1423","volume":"88","author":"A Kattamis","year":"2003","unstructured":"Kattamis A, Kassou C, Berdousi H et al (2003) Combined therapy with desferrioxamine and deferiprone in thalassemic patients: effect on urinary iron excretion. Haematologica 88:1423\u20131425","journal-title":"Haematologica"},{"key":"567_CR81","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejrad.2006.11.016","volume":"62","author":"A Christoforidis","year":"2007","unstructured":"Christoforidis A, Haritandi A, Perifanis V et al (2007) MRI for the determination of pituitary iron overload in children and young adults with beta-thalassaemia major. Eur J Radiol 62:138\u2013142","journal-title":"Eur J Radiol"},{"key":"567_CR82","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.0902-4441.2006.t01-1-EJH3013.x","volume":"78","author":"A Christoforidis","year":"2007","unstructured":"Christoforidis A, Haritandi A, Tsatra I et al (2007) Four-year evaluation of myocardial and liver iron assessed prospectively with serial MRI scans in young patients with beta-thalassaemia major: comparison between different chelation regimens. Eur J Haematol 78:52\u201357","journal-title":"Eur J Haematol"},{"key":"567_CR83","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1148\/radiology.215.3.r00jn10818","volume":"215","author":"G Sparacia","year":"2000","unstructured":"Sparacia G, Iaia A, Banco A et al (2000) Transfusional hemochromatosis: quantitative relation of MR imaging pituitary signal intensity reduction to hypogonadotropic hypogonadism. Radiology 215:818\u2013823","journal-title":"Radiology"},{"key":"567_CR84","doi-asserted-by":"publisher","unstructured":"Argyropoulou MI, Kiortsis DN, Astrakas L et al (2007) Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: a T2 relaxometry study. Eur Radiol. DOI 10.1007\/s00330-007-0683-1","DOI":"10.1007\/s00330-007-0683-1"},{"key":"567_CR85","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood-2004-10-3982","volume":"106","author":"JC Wood","year":"2005","unstructured":"Wood JC, Enriquez C, Ghugre N et al (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106:1460\u20131465","journal-title":"Blood"},{"key":"567_CR86","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/jcp.40.11.1353","volume":"40","author":"MA Aldouri","year":"1987","unstructured":"Aldouri MA, Wonke B, Hoffbrand AV et al (1987) Iron state and hepatic disease in patients with thalassaemia major, treated with long term subcutaneous desferrioxamine. J Clin Pathol 40:1353\u20131359","journal-title":"J Clin Pathol"},{"key":"567_CR87","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1007\/s00330-005-2855-1","volume":"15","author":"E Drakonaki","year":"2005","unstructured":"Drakonaki E, Papakonstantinou O, Maris T et al (2005) Adrenal glands in beta-thalassemia major: magnetic resonance (MR) imaging features and correlation with iron stores. Eur Radiol 15:2462\u20132468","journal-title":"Eur Radiol"},{"key":"567_CR88","doi-asserted-by":"crossref","unstructured":"Kushner JP, Porter JP, Olivieri NF (2001) Secondary iron overload. Hematology Am Soc Hematol Educ Program 47\u201361","DOI":"10.1182\/asheducation-2001.1.47"},{"key":"567_CR89","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/jcp.36.5.539","volume":"36","author":"KC Gatter","year":"1983","unstructured":"Gatter KC, Brown G, Trowbridge IS et al (1983) Transferrin receptors in human tissues: their distribution and possible clinical relevance. J Clin Pathol 36:539\u2013545","journal-title":"J Clin Pathol"},{"key":"567_CR90","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2265.1996.696516.x","volume":"44","author":"SL Atkin","year":"1996","unstructured":"Atkin SL, Burnett HE, Green VL et al (1996) Expression of the transferrin receptor in human anterior pituitary adenomas is confined to gonadotrophinomas. Clin Endocrinol (Oxf) 44:467\u2013471","journal-title":"Clin Endocrinol (Oxf)"},{"key":"567_CR91","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1432-1033.1995.tb20790.x","volume":"232","author":"K Thorstensen","year":"1995","unstructured":"Thorstensen K, Trinder D, Zak O et al (1995) Uptake of iron from N-terminal half-transferrin by isolated rat hepatocytes. Evidence of transferrin-receptor-independent iron uptake. Eur J Biochem 232:129\u2013133","journal-title":"Eur J Biochem"},{"key":"567_CR92","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/bmj.2.5909.16","volume":"2","author":"M Barry","year":"1974","unstructured":"Barry M, Flynn DM, Letsky EA et al (1974) Long-term chelation therapy in thalassaemia major: effect on liver iron concentration, liver histology, and clinical progress. Br Med J 2:16\u201320","journal-title":"Br Med J"},{"key":"567_CR93","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0889-8588(18)30667-1","volume":"1","author":"A Cohen","year":"1987","unstructured":"Cohen A (1987) Management of iron overload in the pediatric patient. Hematol Oncol Clin North Am 1:521\u2013544","journal-title":"Hematol Oncol Clin North Am"},{"key":"567_CR94","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0140-6736(89)90264-X","volume":"2","author":"MG Zurlo","year":"1989","unstructured":"Zurlo MG, De Stefano P, Borgna-Pignatti C et al (1989) Survival and causes of death in thalassaemia major. Lancet 2:27\u201330","journal-title":"Lancet"},{"key":"567_CR95","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-3476(97)70304-4","volume":"130","author":"C Borgna-Pignatti","year":"1997","unstructured":"Borgna-Pignatti C, Rugolotto S, Nobili B et al (1997) A trial of high-dose dexamethasone therapy for chronic idiopathic thrombocytopenic purpura in childhood. J Pediatr 130:13\u201316","journal-title":"J Pediatr"},{"key":"567_CR96","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF02662506","volume":"6","author":"SI Mavrogeni","year":"1998","unstructured":"Mavrogeni SI, Gotsis ED, Markussis V et al (1998) T2 relaxation time study of iron overload in b-thalassemia. Magma 6:7\u201312","journal-title":"Magma"},{"key":"567_CR97","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF02668097","volume":"12","author":"PD Jensen","year":"2001","unstructured":"Jensen PD, Jensen FT, Christensen T et al (2001) Indirect evidence for the potential ability of magnetic resonance imaging to evaluate the myocardial iron content in patients with transfusional iron overload. Magma 12:153\u2013166","journal-title":"Magma"},{"key":"567_CR98","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jmri.20681","volume":"24","author":"T He","year":"2006","unstructured":"He T, Gatehouse PD, Anderson LJ et al (2006) Development of a novel optimized breathhold technique for myocardial T2 measurement in thalassemia. J Magn Reson Imaging 24:580\u2013585","journal-title":"J Magn Reson Imaging"},{"key":"567_CR99","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1182\/blood.V92.9.3455","volume":"92","author":"E Economou-Petersen","year":"1998","unstructured":"Economou-Petersen E, Aessopos A, Kladi A et al (1998) Apolipoprotein E epsilon4 allele as a genetic risk factor for left ventricular failure in homozygous beta-thalassemia. Blood 92:3455\u20133459","journal-title":"Blood"},{"key":"567_CR100","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1046\/j.1365-2141.2001.03006-6.x","volume":"114","author":"M Ferrara","year":"2001","unstructured":"Ferrara M, Matarese SM, Francese M et al (2001) Role of apolipoprotein E (APOE) polymorphism on left cardiac failure in homozygous beta thalassaemic patients. Br J Haematol 114:959\u2013960","journal-title":"Br J Haematol"},{"key":"567_CR101","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/S0735-1097(87)80124-9","volume":"10","author":"LJ Olson","year":"1987","unstructured":"Olson LJ, Edwards WD, McCall JT et al (1987) Cardiac iron deposition in idiopathic hemochromatosis: histologic and analytic assessment of 14 hearts from autopsy. J Am Coll Cardiol 10:1239\u20131243","journal-title":"J Am Coll Cardiol"},{"key":"567_CR102","first-page":"295","volume":"93","author":"C Bergeron","year":"1978","unstructured":"Bergeron C, Kovacs K (1978) Pituitary siderosis. A histologic, immunocytologic, and ultrastructural study. Am J Pathol 93:295\u2013309","journal-title":"Am J Pathol"},{"key":"567_CR103","first-page":"357","volume":"76","author":"KE Oerter","year":"1993","unstructured":"Oerter KE, Kamp GA, Munson PJ et al (1993) Multiple hormone deficiencies in children with hemochromatosis. J Clin Endocrinol Metab 76:357\u2013361","journal-title":"J Clin Endocrinol Metab"},{"key":"567_CR104","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s002340100634","volume":"43","author":"MI Argyropoulou","year":"2001","unstructured":"Argyropoulou MI, Kiortsis DN, Metafratzi Z et al (2001) Pituitary gland height evaluated by MR in patients with beta-thalassemia major: a marker of pituitary gland function. Neuroradiology 43:1056\u20131058","journal-title":"Neuroradiology"},{"key":"567_CR105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02590524","volume":"8","author":"G Sparacia","year":"1999","unstructured":"Sparacia G, Midiri M, D\u2019Angelo P et al (1999) Magnetic resonance imaging of the pituitary gland in patients with secondary hypogonadism due to transfusional hemochromatosis. Magma 8:87\u201390","journal-title":"Magma"},{"key":"567_CR106","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1259\/bjr.74.881.740407","volume":"74","author":"Z Metafratzi","year":"2001","unstructured":"Metafratzi Z, Argyropoulou MI, Kiortsis DN et al (2001) T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major. Br J Radiol 74:407\u2013410","journal-title":"Br J Radiol"},{"issue":"Suppl 2","key":"567_CR107","first-page":"267","volume":"2","author":"C Kattamis","year":"2004","unstructured":"Kattamis C, Ladis V, Tsoussis D et al (2004) Evolution of glucose intolerance and diabetes in transfused patients with thalassemia. Pediatr Endocrinol Rev 2 [Suppl 2]:267\u2013271","journal-title":"Pediatr Endocrinol Rev"},{"key":"567_CR108","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00006676-199303000-00007","volume":"8","author":"L Gullo","year":"1993","unstructured":"Gullo L, Corcioni E, Brancati C et al (1993) Morphologic and functional evaluation of the exocrine pancreas in beta-thalassemia major. Pancreas 8:176\u2013180","journal-title":"Pancreas"},{"key":"567_CR109","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2214\/ajr.173.1.10397124","volume":"173","author":"M Midiri","year":"1999","unstructured":"Midiri M, Lo Casto A, Sparacia G et al (1999) MR imaging of pancreatic changes in patients with transfusion-dependent beta-thalassemia major. AJR 173:187\u2013192","journal-title":"AJR"},{"key":"567_CR110","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10038-004-0202-z","volume":"49","author":"R Martins","year":"2004","unstructured":"Martins R, Picanco I, Fonseca A et al (2004) The role of HFE mutations on iron metabolism in beta-thalassemia carriers. J Hum Genet 49:651\u2013655","journal-title":"J Hum Genet"},{"key":"567_CR111","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2214\/ajr.173.6.10584831","volume":"173","author":"DS Katz","year":"1999","unstructured":"Katz DS (1999) Splenic extramedullary hematopoiesis: large focal lesion in a patient with thalassemia. AJR 173:1715\u20131716","journal-title":"AJR"},{"key":"567_CR112","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF02018614","volume":"21","author":"M Argyropoulou","year":"1991","unstructured":"Argyropoulou M, Perignon F, Brunelle F et al (1991) Height of normal pituitary gland as a function of age evaluated by magnetic resonance imaging in children. Pediatr Radiol 21:247\u2013249","journal-title":"Pediatr Radiol"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-007-0567-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-007-0567-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-007-0567-1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-007-0567-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T19:07:36Z","timestamp":1630436856000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00247-007-0567-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,21]]},"references-count":112,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["567"],"URL":"https:\/\/doi.org\/10.1007\/s00247-007-0567-1","relation":{},"ISSN":["0301-0449","1432-1998"],"issn-type":[{"value":"0301-0449","type":"print"},{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,21]]},"assertion":[{"value":"13 February 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}