{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:27:48Z","timestamp":1788553668384,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Evangelina \u201cEvie\u201d Whitlock Foundation"},{"name":"NIH R21","award":["NS085634"],"award-info":[{"award-number":["NS085634"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00247-018-4283-9","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T23:56:54Z","timestamp":1541462214000},"page":"224-233","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cerebral oxygen metabolism during and after therapeutic hypothermia in neonatal hypoxic\u2013ischemic encephalopathy: a feasibility study using magnetic resonance imaging"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-7441","authenticated-orcid":false,"given":"Anil N.","family":"Shetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Lucke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Sanz Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Hagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili D.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill V.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"4283_CR1","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran S, Laptook AR, Ehrenkranz RA et al (2005) Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353:1574\u20131584","journal-title":"N Engl J Med"},{"key":"4283_CR2","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","volume":"365","author":"PD Gluckman","year":"2005","unstructured":"Gluckman PD, Wyatt JS, Azzopardi D et al (2005) Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet 365:663\u2013670","journal-title":"Lancet"},{"key":"4283_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2431-8-17","volume":"8","author":"D Azzopardi","year":"2008","unstructured":"Azzopardi D, Brocklehurst P, Edwards D et al (2008) The TOBY study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomized controlled trial. BMC Pediatr 8:17","journal-title":"BMC Pediatr"},{"key":"4283_CR4","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jpeds.2010.09.003","volume":"158","author":"SL Bonifacio","year":"2011","unstructured":"Bonifacio SL, Glass HC, VanderPluym J et al (2011) Perinatal events and early MRI in therapeutic hypothermia. J Pediatr 158:360\u2013365","journal-title":"J Pediatr"},{"key":"4283_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/pr.2013.69","volume":"74","author":"D Gano","year":"2013","unstructured":"Gano D, Chau V, Poskitt KJ et al (2013) Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy. Pediatr Res 74:82\u201387","journal-title":"Pediatr Res"},{"key":"4283_CR6","doi-asserted-by":"publisher","first-page":"F238","DOI":"10.1136\/archdischild-2014-306550","volume":"100","author":"E Boudes","year":"2015","unstructured":"Boudes E, Tan X, Saint-Martin C et al (2015) MRI obtained during versus after hypothermia in asphyxiated newborns. Arch Dis Child Fetal Neonatal Ed 100:F238\u2013F242","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"4283_CR7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/1471-2431-14-177","volume":"14","author":"T Agut","year":"2014","unstructured":"Agut T, Leon M, Rebollo M et al (2014) Early identification of brain injury in infants with hypoxic-ischemic encephalopathy at high risk for severe impairments: accuracy of MRI performed in the first days of life. BMC Pediatr 14:177\u2013183","journal-title":"BMC Pediatr"},{"key":"4283_CR8","doi-asserted-by":"publisher","first-page":"F36","DOI":"10.1136\/adc.2010.184291","volume":"96","author":"P Wintermark","year":"2011","unstructured":"Wintermark P, Hansen A, Soul J et al (2011) Early versus late MRI in asphyxiated newborns treated with hypothermia. Arch Dis Child Fetal Neonatal Ed 96:F36\u2013F44","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"4283_CR9","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuroimage.2013.04.072","volume":"85","author":"P Wintermark","year":"2014","unstructured":"Wintermark P, Hansen A, Warfield SK et al (2014) Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in neonates with hypoxic-ischemic encephalopathy treated with hypothermia. Neuroimage 85:287\u2013293","journal-title":"Neuroimage"},{"key":"4283_CR10","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/nbm.3067","volume":"27","author":"P Liu","year":"2014","unstructured":"Liu P, Huang H, Rollins N et al (2014) Quantitative assessment of the global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. NMR Biomed 27:332\u2013340","journal-title":"NMR Biomed"},{"key":"4283_CR11","unstructured":"Adams JA, Fernandes CJ (eds) (2017) Guidelines for acute care of the neonate, 25th edn. Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston"},{"key":"4283_CR12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1089\/ther.2016.0022","volume":"7","author":"TD Stafford","year":"2017","unstructured":"Stafford TD, Hagan JL, Sitler CG et al (2017) Therapeutic hypothermia during neonatal transport: active cooling helps reach the target. Ther Hypothermia Temp Manag 7:88\u201394","journal-title":"Ther Hypothermia Temp Manag"},{"key":"4283_CR13","doi-asserted-by":"publisher","unstructured":"Liu P, Qi Y, Lin Z et al (2018) Assessment of cerebral blood flow in neonates and infants: a phase-contrast MRI study. Neuroimage. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2018.03.020","DOI":"10.1016\/j.neuroimage.2018.03.020"},{"key":"4283_CR14","first-page":"55","volume":"143","author":"SS Kety","year":"1945","unstructured":"Kety SS, Schmidt CF (1945) The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Phys 143:55\u201363","journal-title":"Am J Phys"},{"key":"4283_CR15","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/mrm.21994","volume":"62","author":"F Xu","year":"2009","unstructured":"Xu F, Ge Y, Lu H (2009) Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI. Magn Reson Med 62:141\u2013148","journal-title":"Magn Reson Med"},{"key":"4283_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/mrm.21627","volume":"60","author":"H Lu","year":"2008","unstructured":"Lu H, Ge Y (2008) Quantitative evaluation of oxygenation in venous vessels using T2-relaxation-under-spin-tagging MRI. Magn Reson Med 60:357\u2013363","journal-title":"Magn Reson Med"},{"key":"4283_CR17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/mrm.1189","volume":"46","author":"X Golay","year":"2001","unstructured":"Golay X, Silvennoinen MJ, Zhou J et al (2001) Measurement of tissue oxygen extraction ratios from venous blood T2: increased precision and validation of principle. Magn Reson Med 46:282\u2013291","journal-title":"Magn Reson Med"},{"key":"4283_CR18","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","volume":"30","author":"A Federov","year":"2012","unstructured":"Federov A, Beichel R, Kalpathy-Cramer J et al (2012) 3D slicer as an image computing platform for the quantitative imaging network. Magn Reson Imaging 30:1323\u20131341","journal-title":"Magn Reson Imaging"},{"key":"4283_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/jcbfm.1985.9","volume":"5","author":"P Herscovitch","year":"1985","unstructured":"Herscovitch P, Raichle ME (1985) What is the correct value for the brain-blood partition-coefficient for water? J Cereb Blood Flow Metab 5:65\u201369","journal-title":"J Cereb Blood Flow Metab"},{"key":"4283_CR20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.neuroimage.2014.03.060","volume":"95","author":"JB Vis De","year":"2014","unstructured":"De Vis JB, Petersen ET, Alderliesten T et al (2014) Non-invasive MRI measurements of venous oxygen, oxygen extraction fraction and oxygen consumption in neonates. Neuroimage 95:185\u2013192","journal-title":"Neuroimage"},{"key":"4283_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/jcbfm.2013.165","volume":"34","author":"M Dehaes","year":"2014","unstructured":"Dehaes M, Aggarwal A, Lin PY et al (2014) Cerebral oxygen metabolism in neonatal hypoxic-ischemic encephalopathy during and after therapeutic hypothermia. J Cereb Blood Flow Metab 34:87\u201394","journal-title":"J Cereb Blood Flow Metab"},{"key":"4283_CR22","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1111\/j.1651-2227.1998.tb01530.x","volume":"87","author":"P Ilves","year":"1998","unstructured":"Ilves P, Talvik R, Talvik T (1998) Changes in Doppler ultrasonography in asphyxiated term infants with hypoxic-ischaemic encephalopathy. Acta Paediatr 87:680\u2013684","journal-title":"Acta Paediatr"},{"key":"4283_CR23","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1177\/0271678X15607881","volume":"36","author":"JL Wisnowski","year":"2015","unstructured":"Wisnowski JL, Wu TW, Reitman AJ et al (2015) The effects of therapeutic hypothermia on cerebral metabolism in neonates with hypoxic-ischemic encephalopathy: an in vivo 1H-MR spectroscopy study. J Cereb Blood Flow Metab 36:1075\u20131086","journal-title":"J Cereb Blood Flow Metab"},{"key":"4283_CR24","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3389\/fneur.2018.00293","volume":"9","author":"T-W Wu","year":"2018","unstructured":"Wu T-W, Tamrazi B, Hsu K-H et al (2018) Cerebral lactate concentration in neonatal hypoxic-ischemic encephalopathy: in relation to time, characteristic of injury, and serum lactate concentration. Front Neurol 9:293","journal-title":"Front Neurol"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00247-018-4283-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-018-4283-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-018-4283-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T19:07:29Z","timestamp":1572980849000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00247-018-4283-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["4283"],"URL":"https:\/\/doi.org\/10.1007\/s00247-018-4283-9","relation":{},"ISSN":["0301-0449","1432-1998"],"issn-type":[{"value":"0301-0449","type":"print"},{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,6]]},"assertion":[{"value":"17 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}