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High-resolution peripheral quantitative CT can non-invasively derive bone microarchitectural data. Children with severe osteogenesis imperfecta have fragile deformed bones, and positioning for this scan can be difficult. We assessed the feasibility of high-resolution peripheral quantitative CT in nine children aged 9\u201315\u00a0years with osteogenesis imperfecta and compared results with dual-energy X-ray absorptiometry and with healthy controls. All nine recruited children were successfully scanned and showed no preference for either modality. It therefore appears feasible to perform high-resolution peripheral quantitative CT in children with osteogenesis imperfecta aged 9\u00a0years and older. Future studies should focus on understanding the clinical implications of the technology in this patient cohort.<\/jats:p>","DOI":"10.1007\/s00247-020-04736-8","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T10:39:48Z","timestamp":1593599988000},"page":"1781-1787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High-resolution peripheral quantitative computed tomography in children with osteogenesis imperfecta"],"prefix":"10.1007","volume":"50","author":[{"given":"David J.","family":"Fennimore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Digby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Paggiosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Arundel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dimitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-5036","authenticated-orcid":false,"given":"Amaka C.","family":"Offiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"4736_CR1","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1007\/s11999-010-1702-0","volume":"469","author":"E Donnelly","year":"2011","unstructured":"Donnelly E (2011) Methods for assessing bone quality: a review. 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