{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:12:11Z","timestamp":1791328331039,"version":"4.3.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD081123-01A1"],"award-info":[{"award-number":["R01 HD081123-01A1"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003341","name":"Sarcoma Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00247-021-05156-y","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T06:03:30Z","timestamp":1629353010000},"page":"2521-2529","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ferumoxytol magnetic resonance imaging detects joint and pleural infiltration of bone sarcomas in pediatric and young adult patients"],"prefix":"10.1007","volume":"51","author":[{"given":"Ashok J.","family":"Theruvath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya R.","family":"Nyalakonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffi S.","family":"Avedian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Steffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri L.","family":"Spunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-819X","authenticated-orcid":false,"given":"Heike E.","family":"Daldrup-Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"5156_CR1","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.ejso.2006.10.007","volume":"33","author":"I-W Sim","year":"2007","unstructured":"Sim I-W, Tse LF, Ek ET et al (2007) Salvaging the limb salvage: management of complications following endoprosthetic reconstruction for tumours around the knee. Eur J Surg Oncol 33:796\u2013802","journal-title":"Eur J Surg Oncol"},{"key":"5156_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejso.2016.05.018","volume":"43","author":"M Shahid","year":"2017","unstructured":"Shahid M, Albergo N, Purvis T et al (2017) Management of sarcomas possibly involving the knee joint when to perform extra-articular resection of the knee joint and is it safe? Eur J Surg Oncol 43:175\u2013180","journal-title":"Eur J Surg Oncol"},{"key":"5156_CR3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.2214\/ajr.163.5.7976895","volume":"163","author":"W Schima","year":"1994","unstructured":"Schima W, Amann G, Stiglbauer R et al (1994) Preoperative staging of osteosarcoma: efficacy of MR imaging in detecting joint involvement. AJR Am J Roentgenol 163:1171\u20131175","journal-title":"AJR Am J Roentgenol"},{"key":"5156_CR4","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1080\/000164702753671849","volume":"73","author":"T Ozaki","year":"2002","unstructured":"Ozaki T, Putzke M, Burger H et al (2002) Infiltration of sarcomas into the hip joint: comparison of CT, MRI and histologic findings in 67 cases. Acta Orthop Scand 73:220\u2013226","journal-title":"Acta Orthop Scand"},{"key":"5156_CR5","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/neuros\/nyy578","volume":"85","author":"SL Zuckerman","year":"2019","unstructured":"Zuckerman SL, Amini B, Lee S-H et al (2019) Predictive value of preoperative magnetic resonance imaging findings for survival and local recurrence in patients undergoing en bloc resection of sacral chordomas. Neurosurgery 85:834\u2013842","journal-title":"Neurosurgery"},{"key":"5156_CR6","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1023\/A:1012504904713","volume":"12","author":"JT Tamsma","year":"2001","unstructured":"Tamsma JT, Keizer HJ, Meinders AE (2001) Pathogenesis of malignant ascites: Starling's law of capillary hemodynamics revisited. Ann Oncol 12:1353\u20131357","journal-title":"Ann Oncol"},{"key":"5156_CR7","doi-asserted-by":"crossref","unstructured":"Stein-Werblowsky R (1980) A permeability-enhancing factor produced by tumor. The genesis of malignant effusions. J Cancer Res Clin Oncol 97:315\u2013320","DOI":"10.1007\/BF00405784"},{"key":"5156_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/jso.20268","volume":"91","author":"GMY Quan","year":"2005","unstructured":"Quan GMY, Slavin JL, Schlicht SM et al (2005) Osteosarcoma near joints: assessment and implications. J Surg Oncol 91:159\u2013166","journal-title":"J Surg Oncol"},{"key":"5156_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.kint.2016.12.037","volume":"92","author":"GB Toth","year":"2017","unstructured":"Toth GB, Varallyay CG, Horvath A et al (2017) Current and potential imaging applications of ferumoxytol for magnetic resonance imaging. Kidney Int 92:47\u201366","journal-title":"Kidney Int"},{"key":"5156_CR10","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1148\/radiol.14140510","volume":"275","author":"K Holzapfel","year":"2015","unstructured":"Holzapfel K, Regler J, Baum T et al (2015) Local staging of soft-tissue sarcoma: emphasis on assessment of neurovascular encasement-value of MR imaging in 174 confirmed cases. Radiology 275:501\u2013509","journal-title":"Radiology"},{"key":"5156_CR11","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00247-014-2944-x","volume":"45","author":"M Zidan","year":"2015","unstructured":"Zidan M, Thomas RL, Slovis TL (2015) What you need to know about statistics, part II: reliability of diagnostic and screening tests. Pediatr Radiol 45:317\u2013328","journal-title":"Pediatr Radiol"},{"key":"5156_CR12","doi-asserted-by":"crossref","unstructured":"Runge VM (2017) Critical questions regarding gadolinium deposition in the brain and body after injections of the gadolinium-based contrast agents, safety, and clinical recommendations in consideration of the EMA's Pharmacovigilance and Risk Assessment Committee recommendation for suspension of the marketing authorizations for 4 linear agents. Investig Radiol 52:317\u2013323","DOI":"10.1097\/RLI.0000000000000374"},{"key":"5156_CR13","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1002\/jmri.21969","volume":"30","author":"S Aime","year":"2009","unstructured":"Aime S, Caravan P (2009) Biodistribution of gadolinium-based contrast agents, including gadolinium deposition. J Magn Reson Imaging 30:1259\u20131267","journal-title":"J Magn Reson Imaging"},{"key":"5156_CR14","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.2214\/ajr.172.5.10227514","volume":"172","author":"MG Harisinghani","year":"1999","unstructured":"Harisinghani MG, Saini S, Weissleder R et al (1999) MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation. AJR Am J Roentgenol 172:1347\u20131351","journal-title":"AJR Am J Roentgenol"},{"key":"5156_CR15","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1148\/radiol.2293021045","volume":"229","author":"HE Daldrup-Link","year":"2003","unstructured":"Daldrup-Link HE, Rydland J, Helbich TH et al (2003) Quantification of breast tumor microvascular permeability with feruglose-enhanced MR imaging: initial phase II multicenter trial. Radiology 229:885\u2013892","journal-title":"Radiology"},{"key":"5156_CR16","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1183\/09031936.97.10030714","volume":"10","author":"GT Kinasewitz","year":"1997","unstructured":"Kinasewitz GT (1997) Transudative effusions. Eur Respir J 10:714\u2013718","journal-title":"Eur Respir J"},{"key":"5156_CR17","unstructured":"D'Agostino HP, Edens MA (2020) Physiology, pleural fluid. StatPearls, Treasure Island"},{"key":"5156_CR18","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1002\/jmri.24691","volume":"41","author":"MR Bashir","year":"2015","unstructured":"Bashir MR, Bhatti L, Marin D, Nelson RC (2015) Emerging applications for ferumoxytol as a contrast agent in MRI. J Magn Reson Imaging 41:884\u2013898","journal-title":"J Magn Reson Imaging"},{"key":"5156_CR19","doi-asserted-by":"publisher","first-page":"e0142665","DOI":"10.1371\/journal.pone.0142665","volume":"10","author":"M Aghighi","year":"2015","unstructured":"Aghighi M, Golovko D, Ansari C et al (2015) Imaging tumor necrosis with ferumoxytol. PLoS One 10:e0142665","journal-title":"PLoS One"},{"key":"5156_CR20","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1007\/s00330-019-06569-y","volume":"30","author":"F Siedek","year":"2020","unstructured":"Siedek F, Muehe AM, Theruvath AJ et al (2020) Comparison of ferumoxytol- and gadolinium chelate-enhanced MRI for assessment of sarcomas in children and adolescents. Eur Radiol 30:1790\u20131803","journal-title":"Eur Radiol"},{"key":"5156_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/01.rli.0000191367.61306.83","volume":"41","author":"GH Simon","year":"2006","unstructured":"Simon GH, von Vopelius-Feldt J, Fu Y et al (2006) Ultrasmall supraparamagnetic iron oxide-enhanced magnetic resonance imaging of antigen-induced arthritis: a comparative study between SHU 555 C, ferumoxtran-10, and ferumoxytol. Investig Radiol 41:45\u201351","journal-title":"Investig Radiol"},{"key":"5156_CR22","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1148\/radiol.10101272","volume":"258","author":"S Lefevre","year":"2011","unstructured":"Lefevre S, Ruimy D, Jehl F et al (2011) Septic arthritis: monitoring with USPIO-enhanced macrophage MR imaging. Radiology 258:722\u2013728","journal-title":"Radiology"},{"key":"5156_CR23","doi-asserted-by":"crossref","unstructured":"Simon GH, von Vopelius-Feldt J, Wendland MF et al (2006) MRI of arthritis: comparison of ultrasmall superparamagnetic iron oxide vs. Gd-DTPA. J Magn Reson Imaging 23:720\u2013727","DOI":"10.1002\/jmri.20556"},{"key":"5156_CR24","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ocl.2006.04.002","volume":"37","author":"T Osinski","year":"2006","unstructured":"Osinski T, Malfair D, Steinbach L (2006) Magnetic resonance arthrography. Orthop Clin North Am 37:299\u2013319","journal-title":"Orthop Clin North Am"},{"key":"5156_CR25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1055\/s-2005-872338","volume":"9","author":"WB Morrison","year":"2005","unstructured":"Morrison WB (2005) Indirect MR arthrography: concepts and controversies. Semin Musculoskelet Radiol 9:125\u2013134","journal-title":"Semin Musculoskelet Radiol"},{"key":"5156_CR26","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00247-007-0645-4","volume":"38","author":"D Jaramillo","year":"2008","unstructured":"Jaramillo D, Laor T (2008) Pediatric musculoskeletal MRI: basic principles to optimize success. Pediatr Radiol 38:379\u2013391","journal-title":"Pediatr Radiol"},{"key":"5156_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1148\/radiology.187.1.8451409","volume":"187","author":"CS Winalski","year":"1993","unstructured":"Winalski CS, Aliabadi P, Wright RJ et al (1993) Enhancement of joint fluid with intravenously administered gadopentetate dimeglumine: technique, rationale, and implications. Radiology 187:179\u2013185","journal-title":"Radiology"},{"key":"5156_CR28","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1097\/00004728-199309000-00022","volume":"17","author":"M Yamato","year":"1993","unstructured":"Yamato M, Tamai K, Yamaguchi T, Ohno W (1993) MRI of the knee in rheumatoid arthritis: Gd-DTPA perfusion dynamics. J Comput Assist Tomogr 17:781\u2013785","journal-title":"J Comput Assist Tomogr"},{"key":"5156_CR29","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1002\/1097-0142(19821015)50:8<1649::AID-CNCR2820500832>3.0.CO;2-G","volume":"50","author":"MA Simon","year":"1982","unstructured":"Simon MA, Hecht JD (1982) Invasion of joints by primary bone sarcomas in adults. Cancer 50:1649\u20131655","journal-title":"Cancer"},{"key":"5156_CR30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00247-004-1192-x","volume":"34","author":"H Brisse","year":"2004","unstructured":"Brisse H, Ollivier L, Edeline V et al (2004) Imaging of malignant tumours of the long bones in children: monitoring response to neoadjuvant chemotherapy and preoperative assessment. Pediatr Radiol 34:595\u2013605","journal-title":"Pediatr Radiol"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-021-05156-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-021-05156-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-021-05156-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T16:22:16Z","timestamp":1673108536000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00247-021-05156-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,19]]},"references-count":30,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5156"],"URL":"https:\/\/doi.org\/10.1007\/s00247-021-05156-y","relation":{},"ISSN":["0301-0449","1432-1998"],"issn-type":[{"value":"0301-0449","type":"print"},{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,19]]},"assertion":[{"value":"15 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}