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Coronal water-only Dixon T2-weighted images were used to score the left lower extremity\/pelvis for high signal intensity areas, intensity (0\u20132 scale), extension (0\u20134 scale) and shape and contour in a blinded fashion by two pairs of radiologists.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>For the pelvis, grading of bone marrow signal showed moderate to good intra- and interobserver agreement with kappa values of 0.51\u20130.94 and 0.41\u20130.87, respectively. Corresponding figures for the femur were 0.61\u20130.68 within and 0.32\u20130.61 between observers, and for the tibia 0.60\u20130.72 and 0.51\u20130.73. Agreement for assessing extension was moderate to good both within and between observers for the pelvis (k\u2009=\u20090.52\u20130.85 and 0.35\u20130.80), for the femur (0.52\u20130.67 and 0.51\u20130.60) and for the tibia (k\u2009=\u20090.59\u20130.69 and 0.47\u20130.63) except for the femur metaphysis\/diaphysis, with interobserver kappa values of 0.29\u20130.30. Scoring of shape was moderate to good within observers, but in general poorer between observers, with kappa values of 0.40\u20130.73 and 0.18\u20130.69, respectively. For contour, the corresponding figures were 0.35\u20130.62 and 0.09\u20130.54, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>MRI grading of intensity and extension of high signal intensity areas within the bone marrow of pelvis and lower limb performs well and thus can be used interchangeably by different observers, while assessment of shape and contour is reliable for the same observer but is less reliable between observers. This should be considered when performing clinical trials.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00247-022-05312-y","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T14:03:12Z","timestamp":1650549792000},"page":"1272-1282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Whole-body MRI in children aged 6\u201318\u00a0years. Reliability of identifying and grading high signal intensity changes within bone marrow"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-7843","authenticated-orcid":false,"given":"Pia","family":"Zadig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-3835","authenticated-orcid":false,"given":"Elisabeth","family":"von Brandis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-5571","authenticated-orcid":false,"given":"Paola","family":"d\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-5418","authenticated-orcid":false,"given":"Laura Tanturri","family":"de Horatio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-4984","authenticated-orcid":false,"given":"Lil-Sofie","family":"Ording-M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0135-2169","authenticated-orcid":false,"given":"Karen","family":"Rosendahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4279-7540","authenticated-orcid":false,"given":"Derk","family":"Avenarius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"5312_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00247-020-04735-9","volume":"51","author":"P Zadig","year":"2020","unstructured":"Zadig P, von Brandis E, Lein RK et al (2020) Whole-body magnetic resonance imaging in children - how and why? 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