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Recently, shear wave elastography (SWE) emerged as a tool for assessing pancreatic stiffness in chronic pancreatitis and pancreatic cancer with a few studies assessing it in diabetes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To compare pancreatic SWE in children with recent-onset and long-standing type 1 diabetes to healthy controls and to correlate it with diabetes duration, glycated hemoglobin (HbA1C), functional B cell reserve (fasting C-peptide) and diabetic complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Fifty children with type 1 diabetes (25 with recent-onset and 25 with long-standing type 1 diabetes) and 50 controls were enrolled. Diabetes duration, insulin therapy, fundoscopic examination of the eyes and the neuropathy disability score were assessed. Fasting C-peptide, lipids, HbA1C and urinary albumin-creatinine ratio were measured. Pancreatic SWE was measured using the General Electric Logiq P9 ultrasound system.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean SWE of the studied children with recent-onset type 1 diabetes was 4.81\u00b10.62 kilopascals (Kpa), those with long-standing type 1 diabetes was 7.10\u00b11.56Kpa and for controls was 5.57\u00b10.27 Kpa (<jats:italic>P<\/jats:italic>&lt;0.001). SWE was positively correlated to diabetes duration (<jats:italic>P<\/jats:italic>&lt;0.001) and negatively correlated to fasting C-peptide (<jats:italic>P<\/jats:italic>&lt;0.001). Regarding diabetes complications, SWE was positively correlated to frequency of severe hypoglycemia (<jats:italic>P<\/jats:italic>=0.005), HbA1C (<jats:italic>P<\/jats:italic>=0.03), low-density lipoproteins (<jats:italic>P<\/jats:italic>&lt;0.001) and cholesterol (<jats:italic>P<\/jats:italic>&lt;0.001) and significantly related to diabetic neuropathy (<jats:italic>P<\/jats:italic>=0.04) and nephropathy (<jats:italic>P<\/jats:italic>=0.05). Diabetes duration, fasting C-peptide, HbA1C and frequency of severe hypoglycemia were the significant independent variables related to SWE increase by multivariable regression analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Pancreatic SWE changes significantly with duration of type 1 diabetes, being lowest in those with recent-onset type 1 diabetes and highest in those with long-standing type 1 diabetes, particularly those with diabetic nephropathy and neuropathy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00247-022-05363-1","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T04:03:27Z","timestamp":1650686607000},"page":"2348-2358","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pancreatic shear wave elastography in children with type 1 diabetes: relation to diabetes duration, glycemic indices, fasting C-peptide and diabetic complications"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-8835","authenticated-orcid":false,"given":"Nouran Yousef","family":"Salah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-6539","authenticated-orcid":false,"given":"Sherihane Said","family":"Madkour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4437-6432","authenticated-orcid":false,"given":"Khaled Sayed","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"5363_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12880-018-0295-z","volume":"18","author":"S P\u00fcttmann","year":"2018","unstructured":"P\u00fcttmann S, Koch J, Steinacker J et al (2018) Ultrasound point shear wave elastography of the pancreas: comparison of patients with type 1 diabetes and healthy volunteers \u2013 results from a pilot study. 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