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However, there is a poor understanding of which patients will experience Fontan failure and when. 4D flow MRI has identified several metrics of clinical interest, but longitudinal studies investigating hemodynamics in Fontan patients are lacking.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>We aimed to investigate the relationship between flow distribution to the pulmonary arteries and regional hemodynamic metrics in a unique cohort with follow-up 4D flow MRI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Patients with\u2009&gt;\u20096\u00a0months of 4D flow MRI follow-up were included. Flow distribution from the caval veins to pulmonary arteries was measured in addition to regional measures of peak velocity, viscous energy loss (EL<jats:sub>mean<\/jats:sub> and EL<jats:sub>tot<\/jats:sub>), and kinetic energy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ten patients with total cavopulmonary connection (17.7\u2009\u00b1\u20098.8\u00a0years at baseline, follow-up: 4.4\u2009\u00b1\u20092.6\u00a0years) were included. Five subjects had unequal flow distribution from the IVC to the pulmonary arteries at baseline. Over time, these subjects tended to have larger increases in peak velocity (39.2% vs 6.6%), EL<jats:sub>mean<\/jats:sub> (11.6% vs -38.3%), EL<jats:sub>tot<\/jats:sub> (9.5% vs -36.2%), and kinetic energy (96.1% vs 36.3%) in the IVC. However, these differences were statistically insignificant. We found that changes in EL<jats:sub>mean<\/jats:sub> and EL<jats:sub>tot<\/jats:sub> were significantly associated with changes in peak velocity in the caval veins (R<jats:sup>2<\/jats:sup>\u2009&gt;\u20090.5, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Unequal flow distribution from the IVC may drive increasing peak velocities and viscous energy losses, which have been associated with worse clinical outcomes. Changes in peak velocity may serve as a surrogate measure for changes in viscous energy loss.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00247-023-05591-z","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T02:02:31Z","timestamp":1678154551000},"page":"900-909","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of pulmonary artery flow distribution on Fontan hemodynamics and flow energetics"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-7267","authenticated-orcid":false,"given":"Elizabeth K.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Sodhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-2333","authenticated-orcid":false,"given":"Cynthia K.","family":"Rigsby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"5591_CR1","doi-asserted-by":"publisher","first-page":"e004809","DOI":"10.1161\/JAHA.116.004809","volume":"6","author":"DJ Goldberg","year":"2017","unstructured":"Goldberg DJ, Surrey LF, Glatz AC et al (2017) Hepatic fibrosis is universal following Fontan operation, and severity is associated with time from surgery: a liver biopsy and hemodynamic study. 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