{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:28:30Z","timestamp":1793521710022,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100015038","name":"Society for Pediatric Radiology","doi-asserted-by":"publisher","award":["2017-multi institutional"],"award-info":[{"award-number":["2017-multi institutional"]}],"id":[{"id":"10.13039\/100015038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Splenic stiffness is a potential imaging marker of portal hypertension. Normative spleen stiffness values are needed to define diagnostic thresholds.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To report stiffness measurements of the spleen in healthy children undergoing liver magnetic resonance (MR) elastography across MRI vendors and field strengths.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods<\/jats:title>\n            <jats:p>This was a post-hoc analysis of data collected under a prospective multicenter cross-sectional study. Volunteers aged 7\u201317.9\u00a0years without a known history of liver or spleen disease were recruited for a research MRI between February 2018 and October 2019. Gradient recalled echo (GRE) or spin-echo\u2013echo-planar imaging (SE-EPI) MR elastography was performed on a total of three vendor platforms and at two field strengths (1.5\u00a0T (T) and 3\u00a0T) with standard right upper quadrant passive driver placement (frequency of 60\u00a0Hz). Two independent reviewers measured spleen stiffness, length, and volume. Descriptive statistics, independent sample <jats:italic>t<\/jats:italic>-tests or Mann\u2013Whitney test, and Pearson\u2019s or Spearman\u2019s correlation were used.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>From 101 study volunteers, 72 (34 female) had measurable splenic stiffness. Median age was 12\u00a0years (interquartile range [IQR], 9.9\u201314.9\u00a0years). Mean (\u00b1\u2009SD) spleen stiffness was 4.7\u2009\u00b1\u20090.9\u00a0kPa (IQR, 3.8\u20135.4\u00a0kPa) with 6.1\u00a0kPa reflecting the 95th percentile. Strong correlation was observed between reviewers (ICC\u2009=\u20090.89 [95%CI, 0.71\u20130.93; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001]). Male volunteers had slightly higher splenic stiffness compared to females: 4.9\u2009\u00b1\u20090.9 vs. 4.3\u2009\u00b1\u20090.8\u00a0kPa (<jats:italic>P<\/jats:italic>\u2009=\u20090.014). There was significant correlation between spleen stiffness and body mass index (<jats:italic>r<\/jats:italic>\u2009=\u20090.33 [95%CI, 0.06\u20130.56; <jats:italic>P<\/jats:italic>\u2009=\u20090.024]) but no other measure of patient size (<jats:italic>r<\/jats:italic>\u2009=\u20090.15\u20130.29). No significant difference in spleen stiffness was observed across vendors (<jats:italic>P<\/jats:italic>\u2009=\u20090.089) or field strengths (<jats:italic>P<\/jats:italic>\u2009=\u20090.236).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>MR elastography\u2013based spleen stiffness, measured as part of a liver MR elastography acquisition, is\u2009&lt;\u20096.1\u00a0kPa in a healthy pediatric population and does not vary with MRI vendor or field strength.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00247-024-06107-z","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T07:14:36Z","timestamp":1737530076000},"page":"846-856","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spleen stiffness in a healthy pediatric population undergoing liver magnetic resonance elastography"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8821-0971","authenticated-orcid":false,"given":"Suraj D.","family":"Serai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Glenn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-4054","authenticated-orcid":false,"given":"Andrew T.","family":"Trout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-5227","authenticated-orcid":false,"given":"Wondwossen T.","family":"Lerebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-5168","authenticated-orcid":false,"given":"Michael S.","family":"Gee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-2638","authenticated-orcid":false,"given":"Geetika","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7784-3108","authenticated-orcid":false,"given":"Sudha A.","family":"Anupindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"6107_CR1","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1148\/radiol.2018172099","volume":"287","author":"AT Trout","year":"2018","unstructured":"Trout AT, Sheridan RM, Serai SD et al (2018) Diagnostic performance of MR elastography for liver fibrosis in children and young adults with a spectrum of liver diseases. 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