{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:08:41Z","timestamp":1767996521511,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["PP-1905-34002."],"award-info":[{"award-number":["PP-1905-34002."]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS121657, R01 NS133228, R01 EB019483, S10OD025111"],"award-info":[{"award-number":["R01 NS121657, R01 NS133228, R01 EB019483, S10OD025111"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"DOI":"10.1007\/s00247-025-06213-6","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T10:02:57Z","timestamp":1742205777000},"page":"1138-1147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimizing T2* imaging for adolescent and young adult patients at 7\u00a0T"],"prefix":"10.1007","volume":"55","author":[{"given":"Sergio","family":"Valencia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fedel","family":"Machado-Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Avesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil J.","family":"Barkovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel C. D.","family":"Cartmell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon K.","family":"Warfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Jaimes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Afacan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"6213_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s41747-021-00225-x","volume":"5","author":"M Cosottini","year":"2021","unstructured":"Cosottini M, Roccatagliata L (2021) Neuroimaging at 7 T: are we ready for clinical transition? Eur Radiol Exp 5:37. https:\/\/doi.org\/10.1186\/s41747-021-00225-x","journal-title":"Eur Radiol Exp"},{"key":"6213_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s41747-021-00222-0","volume":"5","author":"B Vachha","year":"2021","unstructured":"Vachha B, Huang SY (2021) MRI with ultrahigh field strength and high-performance gradients: challenges and opportunities for clinical neuroimaging at 7 T and beyond. Eur Radiol Exp 5:35. https:\/\/doi.org\/10.1186\/s41747-021-00222-0","journal-title":"Eur Radiol Exp"},{"key":"6213_CR3","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1007\/s00330-020-06847-5","volume":"30","author":"S Cocozza","year":"2020","unstructured":"Cocozza S, Cosottini M, Signori A et al (2020) A clinically feasible 7-tesla protocol for the identification of cortical lesions in multiple sclerosis. Eur Radiol 30:4586\u20134594. https:\/\/doi.org\/10.1007\/s00330-020-06847-5","journal-title":"Eur Radiol"},{"key":"6213_CR4","doi-asserted-by":"publisher","first-page":"fcae359","DOI":"10.1093\/braincomms\/fcae359","volume":"6","author":"DM Harrison","year":"2024","unstructured":"Harrison DM, Sati P, Klawiter EC et al (2024) The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Brain Commun 6:fcae359. https:\/\/doi.org\/10.1093\/braincomms\/fcae359","journal-title":"Brain Commun"},{"key":"6213_CR5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.mric.2021.07.005","volume":"29","author":"DK Deelchand","year":"2021","unstructured":"Deelchand DK, Ho M-L, Nestrasil I (2021) Ultra-high-field imaging of the pediatric brain and spinal cord. Magn Reson Imaging Clin N Am 29:643\u2013653. https:\/\/doi.org\/10.1016\/j.mric.2021.07.005","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"6213_CR6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2463\/mrms.mp.2021-0152","volume":"21","author":"T Okada","year":"2022","unstructured":"Okada T, Akasaka T, Thuy DH, Isa T (2022) Safety for human MR scanners at 7T. Magn Reson Med Sci 21:531\u2013537. https:\/\/doi.org\/10.2463\/mrms.mp.2021-0152","journal-title":"Magn Reson Med Sci"},{"key":"6213_CR7","unstructured":"U.S. Food and Drug Administration (2017) FDA clears first 7T magnetic resonance imaging device. U.S. Food and Drug Administration.\u00a0https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-clears-first-7t-magnetic-resonance-imaging-device. Accessed 18 Dec 2024"},{"key":"6213_CR8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/jmri.27412","volume":"53","author":"AJ Fagan","year":"2021","unstructured":"Fagan AJ, Bitz AK, Bj\u00f6rkman-Burtscher IM et al (2021) 7T MR safety. J Magn Reson Imaging 53:333\u2013346. https:\/\/doi.org\/10.1002\/jmri.27412","journal-title":"J Magn Reson Imaging"},{"key":"6213_CR9","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.3174\/ajnr.A6695","volume":"41","author":"KV Annink","year":"2020","unstructured":"Annink KV, van der Aa NE, Dudink J et al (2020) Introduction of ultra-high-field MR imaging in infants: preparations and feasibility. AJNR Am J Neuroradiol 41:1532\u20131537. https:\/\/doi.org\/10.3174\/ajnr.A6695","journal-title":"AJNR Am J Neuroradiol"},{"key":"6213_CR10","doi-asserted-by":"publisher","first-page":"e0219705","DOI":"10.1371\/journal.pone.0219705","volume":"14","author":"W Bian","year":"2019","unstructured":"Bian W, Kerr AB, Tranvinh E et al (2019) MR susceptibility contrast imaging using a 2D simultaneous multi-slice gradient-echo sequence at 7T. PLoS ONE 14:e0219705. https:\/\/doi.org\/10.1371\/journal.pone.0219705","journal-title":"PLoS ONE"},{"key":"6213_CR11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuroimage.2017.02.068","volume":"168","author":"JH Duyn","year":"2018","unstructured":"Duyn JH (2018) Studying brain microstructure with magnetic susceptibility contrast at high-field. Neuroimage 168:152\u2013161. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.02.068","journal-title":"Neuroimage"},{"key":"6213_CR12","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1007\/s00415-023-11947-1","volume":"271","author":"G Hangel","year":"2024","unstructured":"Hangel G, Kasprian G, Chambers S et al (2024) Implementation of a 7T epilepsy task force consensus imaging protocol for routine presurgical epilepsy work-up: effect on diagnostic yield and lesion delineation. J Neurol 271:804\u2013818. https:\/\/doi.org\/10.1007\/s00415-023-11947-1","journal-title":"J Neurol"},{"key":"6213_CR13","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.neuroimage.2017.03.060","volume":"168","author":"S Trattnig","year":"2018","unstructured":"Trattnig S, Springer E, Bogner W et al (2018) Key clinical benefits of neuroimaging at 7T. Neuroimage 168:477\u2013489. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.03.060","journal-title":"Neuroimage"},{"key":"6213_CR14","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/jon.12419","volume":"27","author":"R Datta","year":"2017","unstructured":"Datta R, Sethi V, Ly S et al (2017) 7T MRI visualization of cortical lesions in adolescents and young adults with pediatric-onset multiple sclerosis. J Neuroimaging 27:447\u2013452. https:\/\/doi.org\/10.1111\/jon.12419","journal-title":"J Neuroimaging"},{"key":"6213_CR15","doi-asserted-by":"publisher","first-page":"S88","DOI":"10.1212\/WNL.0000000000002826","volume":"87","author":"B Banwell","year":"2016","unstructured":"Banwell B, Arnold DL, Tillema J-M et al (2016) MRI in the evaluation of pediatric multiple sclerosis. Neurology 87:S88\u2013S96. https:\/\/doi.org\/10.1212\/WNL.0000000000002826","journal-title":"Neurology"},{"key":"6213_CR16","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.neuroimage.2017.03.026","volume":"168","author":"R Sclocco","year":"2018","unstructured":"Sclocco R, Beissner F, Bianciardi M et al (2018) Challenges and opportunities for brainstem neuroimaging with ultrahigh field MRI. Neuroimage 168:412\u2013426. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.03.026","journal-title":"Neuroimage"},{"key":"6213_CR17","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.neuroimage.2006.04.229","volume":"32","author":"T-Q Li","year":"2006","unstructured":"Li T-Q, van Gelderen P, Merkle H et al (2006) Extensive heterogeneity in white matter intensity in high-resolution T2*-weighted MRI of the human brain at 7.0 T. Neuroimage 32:1032\u20131040. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.04.229","journal-title":"Neuroimage"},{"key":"6213_CR18","doi-asserted-by":"publisher","first-page":"991","DOI":"10.2174\/1573405615666191219102044","volume":"16","author":"W Fan","year":"2020","unstructured":"Fan W, Wang X, Zhang X et al (2020) Investigating optimal echo times for quantitative susceptibility mapping of basal ganglia nuclei in the healthy brain. Curr Med Imaging 16:991\u2013996. https:\/\/doi.org\/10.2174\/1573405615666191219102044","journal-title":"Curr Med Imaging"},{"key":"6213_CR19","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/s41598-023-28293-6","volume":"13","author":"S Shin","year":"2023","unstructured":"Shin S, Yun SD, Shah NJ (2023) T2* quantification using multi-echo gradient echo sequences: a comparative study of different readout gradients. Sci Rep 13:1138. https:\/\/doi.org\/10.1038\/s41598-023-28293-6","journal-title":"Sci Rep"},{"key":"6213_CR20","doi-asserted-by":"publisher","first-page":"103303","DOI":"10.1016\/j.nicl.2022.103303","volume":"37","author":"D Putcha","year":"2023","unstructured":"Putcha D, Katsumi Y, Brickhouse M et al (2023) Gray to white matter signal ratio as a novel biomarker of neurodegeneration in Alzheimer\u2019s disease. Neuroimage Clin 37:103303. https:\/\/doi.org\/10.1016\/j.nicl.2022.103303","journal-title":"Neuroimage Clin"},{"key":"6213_CR21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159\u2013174. https:\/\/doi.org\/10.2307\/2529310","journal-title":"Biometrics"},{"key":"6213_CR22","doi-asserted-by":"publisher","first-page":"950650","DOI":"10.3389\/fnana.2022.950650","volume":"16","author":"J-M Shim","year":"2022","unstructured":"Shim J-M, Cho S-E, Kang S-G, Kang C-K (2022) Quantitative myelin-related maps from R1 and T2* ratio images using a single ME-MP2RAGE sequence in 7T MRI. Front Neuroanat 16:950650. https:\/\/doi.org\/10.3389\/fnana.2022.950650","journal-title":"Front Neuroanat"},{"key":"6213_CR23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3174\/ajnr.A4142","volume":"36","author":"A De Ciantis","year":"2015","unstructured":"De Ciantis A, Barkovich AJ, Cosottini M et al (2015) Ultra-high-field MR imaging in polymicrogyria and epilepsy. AJNR Am J Neuroradiol 36:309\u2013316. https:\/\/doi.org\/10.3174\/ajnr.A4142","journal-title":"AJNR Am J Neuroradiol"},{"key":"6213_CR24","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3174\/ajnr.A6307","volume":"41","author":"JW Rutland","year":"2020","unstructured":"Rutland JW, Delman BN, Gill CM et al (2020) Emerging use of ultra-high-field 7T MRI in the study of intracranial vascularity: state of the field and future directions. AJNR Am J Neuroradiol 41:2\u20139. https:\/\/doi.org\/10.3174\/ajnr.A6307","journal-title":"AJNR Am J Neuroradiol"},{"key":"6213_CR25","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1148\/rg.295095186","volume":"29","author":"GB Chavhan","year":"2009","unstructured":"Chavhan GB, Babyn PS, Thomas B et al (2009) Principles, techniques, and applications of T2*-based MR imaging and its special applications. Radiographics 29:1433\u20131449. https:\/\/doi.org\/10.1148\/rg.295095186","journal-title":"Radiographics"},{"key":"6213_CR26","doi-asserted-by":"publisher","first-page":"W440","DOI":"10.2214\/AJR.11.7488","volume":"198","author":"S Verschuuren","year":"2012","unstructured":"Verschuuren S, Poretti A, Buerki S et al (2012) Susceptibility-weighted imaging of the pediatric brain. AJR Am J Roentgenol 198:W440\u2013W449. https:\/\/doi.org\/10.2214\/AJR.11.7488","journal-title":"AJR Am J Roentgenol"},{"key":"6213_CR27","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1001\/jamaneurol.2013.217","volume":"70","author":"N Mistry","year":"2013","unstructured":"Mistry N, Dixon J, Tallantyre E et al (2013) Central veins in brain lesions visualized with high-field magnetic resonance imaging: a pathologically specific diagnostic biomarker for inflammatory demyelination in the brain. JAMA Neurol 70:623\u2013628. https:\/\/doi.org\/10.1001\/jamaneurol.2013.217","journal-title":"JAMA Neurol"},{"key":"6213_CR28","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1177\/1352458515616207","volume":"22","author":"N Mistry","year":"2016","unstructured":"Mistry N, Abdel-Fahim R, Samaraweera A et al (2016) Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions. Mult Scler 22:1289\u20131296. https:\/\/doi.org\/10.1177\/1352458515616207","journal-title":"Mult Scler"},{"key":"6213_CR29","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1212\/WNL.0b013e31820af878","volume":"76","author":"EC Tallantyre","year":"2011","unstructured":"Tallantyre EC, Dixon JE, Donaldson I et al (2011) Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions. Neurology 76:534\u2013539. https:\/\/doi.org\/10.1212\/WNL.0b013e31820af878","journal-title":"Neurology"},{"key":"6213_CR30","doi-asserted-by":"publisher","first-page":"e35241","DOI":"10.1371\/journal.pone.0035241","volume":"7","author":"JY Kwan","year":"2012","unstructured":"Kwan JY, Jeong SY, Van Gelderen P et al (2012) Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology. PLoS ONE 7:e35241. https:\/\/doi.org\/10.1371\/journal.pone.0035241","journal-title":"PLoS ONE"},{"key":"6213_CR31","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1148\/rg.295095034","volume":"29","author":"GB Chavhan","year":"2009","unstructured":"Chavhan GB, Babyn PS, Thomas B, Shroff MM, Haacke EM (2009) Principles, techniques, and applications of T2*-based MR imaging and its special applications. Radiographics 29:1433\u20131449. https:\/\/doi.org\/10.1148\/rg.295095034","journal-title":"Radiographics"},{"key":"6213_CR32","first-page":"83","volume":"1","author":"Y Ge","year":"2010","unstructured":"Ge Y, Zohrabian VM, Grossman RI (2010) Three-dimensional high resolution venography using susceptibility weighted imaging at 7T. Chin J Magn Reson Imaging 1:83\u201393","journal-title":"Chin J Magn Reson Imaging"},{"key":"6213_CR33","first-page":"291","volume":"18","author":"N Girard","year":"1991","unstructured":"Girard N, Raybaud C, du Lac P (1991) MRI study of brain myelination. J Neuroradiol 18:291\u2013307","journal-title":"J Neuroradiol"}],"updated-by":[{"DOI":"10.1007\/s00247-025-06229-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000}}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-025-06213-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-025-06213-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-025-06213-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T09:51:32Z","timestamp":1748425892000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00247-025-06213-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["6213"],"URL":"https:\/\/doi.org\/10.1007\/s00247-025-06213-6","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00247-025-06229-y","asserted-by":"object"}]},"ISSN":["1432-1998"],"issn-type":[{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"5 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: In this article, 'Camilo Jaimes' should have been denoted as an equal co-senior author role instead of 'Simon K. Warfield'.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00247-025-06229-y","URL":"https:\/\/doi.org\/10.1007\/s00247-025-06229-y","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}