{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:11:51Z","timestamp":1784945511686,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Wuhan Municipal Health Commission","award":["WX21Z64"],"award-info":[{"award-number":["WX21Z64"]}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2021CFB177"],"award-info":[{"award-number":["2021CFB177"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wuhan Children\u2019s Hospital","award":["2022FEYJS002"],"award-info":[{"award-number":["2022FEYJS002"]}]},{"name":"Wuhan Clinical Research Center for Children\u2019s Medical Imaging","award":["WSTB2022-38"],"award-info":[{"award-number":["WSTB2022-38"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"DOI":"10.1007\/s00247-025-06248-9","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:36:39Z","timestamp":1746185799000},"page":"1335-1341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Value of amide proton transfer imaging in neonatal hypoxic-ischemic encephalopathy"],"prefix":"10.1007","volume":"55","author":[{"given":"Yu","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"6248_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/AOG.0000000000005392","volume":"143","author":"T Arnautovic","year":"2024","unstructured":"Arnautovic T, Sinha S, Laptook AR (2024) Neonatal hypoxic-ischemic encephalopathy and hypothermia treatment. Obstet Gynecol 143:67\u201381","journal-title":"Obstet Gynecol"},{"key":"6248_CR2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s12519-023-00698-7","volume":"19","author":"I Caramelo","year":"2023","unstructured":"Caramelo I, Coelho M, Rosado M et al (2023) Biomarkers of hypoxic-ischemic encephalopathy: a systematic review. World J Pediatr 19:505\u2013548","journal-title":"World J Pediatr"},{"key":"6248_CR3","doi-asserted-by":"publisher","first-page":"A2","DOI":"10.1016\/j.jpeds.2012.02.022","volume":"160","author":"RI Clyman","year":"2012","unstructured":"Clyman RI (2012) Late outcome following neonatal hypoxic-ischemic encephalopathy. J Pediatr 160:A2\u2013A3","journal-title":"J Pediatr"},{"key":"6248_CR4","doi-asserted-by":"publisher","first-page":"151639","DOI":"10.1016\/j.semperi.2022.151639","volume":"46","author":"SL Bonifacio","year":"2022","unstructured":"Bonifacio SL, Chalak LF, Van Meurs KP et al (2022) Neuroprotection for hypoxic-ischemic encephalopathy: contributions from the neonatal research network. Semin Perinatol 46:151639","journal-title":"Semin Perinatol"},{"key":"6248_CR5","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1053\/j.semperi.2016.09.007","volume":"40","author":"G Natarajan","year":"2016","unstructured":"Natarajan G, Pappas A, Shankaran S (2016) Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE). Semin Perinatol 40:549\u2013555","journal-title":"Semin Perinatol"},{"key":"6248_CR6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jpeds.2013.10.067","volume":"164","author":"LF Chalak","year":"2014","unstructured":"Chalak LF, Sanchez PJ, Adams-Huet B et al (2014) Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy. J Pediatr 164:468\u201374 e1","journal-title":"J Pediatr"},{"key":"6248_CR7","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/s41390-023-02510-8","volume":"94","author":"YW Wu","year":"2023","unstructured":"Wu YW, Monsell SE, Glass HC et al (2023) How well does neonatal neuroimaging correlate with neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy? Pediatr Res 94:1018\u20131025","journal-title":"Pediatr Res"},{"key":"6248_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/1817-1745.205646","volume":"12","author":"S Bano","year":"2017","unstructured":"Bano S, Chaudhary V, Garga UC (2017) Neonatal hypoxic-ischemic encephalopathy: a radiological review. J Pediatr Neurosci 12:1\u20136","journal-title":"J Pediatr Neurosci"},{"key":"6248_CR9","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1001\/archpediatrics.2012.284","volume":"166","author":"JL Cheong","year":"2012","unstructured":"Cheong JL, Coleman L, Hunt RW et al (2012) Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial. Arch Pediatr Adolesc Med 166:634\u2013640","journal-title":"Arch Pediatr Adolesc Med"},{"key":"6248_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2174\/1874440001812010055","volume":"12","author":"KA Jisa","year":"2018","unstructured":"Jisa KA, Clarey DD, Peeples ES (2018) Magnetic resonance imaging findings of term and preterm hypoxic-ischemic encephalopathy: a review of relevant animal models and correlation to human imaging. Open Neuroimag J 12:55\u201365","journal-title":"Open Neuroimag J"},{"key":"6248_CR11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.pediatrneurol.2012.05.009","volume":"47","author":"SB Mulkey","year":"2012","unstructured":"Mulkey SB, Yap VL, Swearingen CJ et al (2012) Quantitative cranial magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy. Pediatr Neurol 47:101\u2013108","journal-title":"Pediatr Neurol"},{"key":"6248_CR12","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s00247-014-2945-9","volume":"44","author":"F Cavalleri","year":"2014","unstructured":"Cavalleri F, Lugli L, Pugliese M et al (2014) Prognostic value of diffusion-weighted imaging summation scores or apparent diffusion coefficient maps in newborns with hypoxic-ischemic encephalopathy. Pediatr Radiol 44:1141\u20131154","journal-title":"Pediatr Radiol"},{"key":"6248_CR13","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1007\/s00247-013-2864-1","volume":"44","author":"KA Cauley","year":"2014","unstructured":"Cauley KA, Filippi CG (2014) Apparent diffusion coefficient histogram analysis of neonatal hypoxic-ischemic encephalopathy. Pediatr Radiol 44:738\u2013746","journal-title":"Pediatr Radiol"},{"key":"6248_CR14","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1136\/pgmj.2004.030114","volume":"81","author":"Y Cheng","year":"2005","unstructured":"Cheng Y, Liu GR, Guan JT et al (2005) Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy. Postgrad Med J 81:589\u2013593","journal-title":"Postgrad Med J"},{"key":"6248_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000472709","volume":"39","author":"HR Berger","year":"2017","unstructured":"Berger HR, Brekke E, Wider\u00f8e M, Morken TS (2017) Neuroprotective treatments after perinatal hypoxic-ischemic brain injury evaluated with magnetic resonance spectroscopy. Dev Neurosci 39:36\u201348","journal-title":"Dev Neurosci"},{"key":"6248_CR16","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00234-013-1202-5","volume":"55","author":"G Ancora","year":"2013","unstructured":"Ancora G, Testa C, Grandi S et al (2013) Prognostic value of brain proton MR spectroscopy and diffusion tensor imaging in newborns with hypoxic-ischemic encephalopathy treated by brain cooling. Neuroradiology 55:1017\u20131025","journal-title":"Neuroradiology"},{"key":"6248_CR17","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41390-021-01626-z","volume":"91","author":"H Barta","year":"2022","unstructured":"Barta H, Jermendy A, Kovacs L et al (2022) Predictive performance and metabolite dynamics of proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy. Pediatr Res 91:581\u2013589","journal-title":"Pediatr Res"},{"key":"6248_CR18","doi-asserted-by":"publisher","first-page":"1234049","DOI":"10.3389\/fnins.2023.1234049","volume":"17","author":"J Bao","year":"2023","unstructured":"Bao J, Zhang X, Zhao X (2023) MR imaging and outcome in neonatal HIBD models are correlated with sex: the value of diffusion tensor MR imaging and diffusion kurtosis MR imaging. Front Neurosci-switz 17:1234049","journal-title":"Front Neurosci-switz"},{"key":"6248_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s40001-023-01090-x","volume":"28","author":"Y Han","year":"2023","unstructured":"Han Y, Wu P, Tian J et al (2023) Diffusion kurtosis imaging and diffusion weighted imaging comparison in diagnosis of early hypoxic-ischemic brain edema. Eur J Med Res 28:159","journal-title":"Eur J Med Res"},{"key":"6248_CR20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00330-014-3352-1","volume":"25","author":"JB De Vis","year":"2015","unstructured":"De Vis JB, Hendrikse J, Petersen ET et al (2015) Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy. Eur Radiol 25:113\u2013121","journal-title":"Eur Radiol"},{"key":"6248_CR21","doi-asserted-by":"publisher","first-page":"985","DOI":"10.31083\/j.jin2004099","volume":"20","author":"L Meng","year":"2021","unstructured":"Meng L, Wang Q, Li Y et al (2021) Diagnostic performance of arterial spin-labeled perfusion imaging and diffusion-weighted imaging in full-term neonatal hypoxic-ischemic encephalopathy. JIN 20:985\u2013991","journal-title":"JIN"},{"key":"6248_CR22","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/nm907","volume":"9","author":"J Zhou","year":"2003","unstructured":"Zhou J, Payen J-F, Wilson DA et al (2003) Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 9:1085\u20131090","journal-title":"Nat Med"},{"key":"6248_CR23","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/jmri.26645","volume":"50","author":"J Zhou","year":"2019","unstructured":"Zhou J, Heo H-Y, Knutsson L et al (2019) APT-weighted MRI: techniques, current neuro applications, and challenging issues. J Magn Reson Imaging 50:347\u2013364","journal-title":"J Magn Reson Imaging"},{"key":"6248_CR24","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.neuroimage.2016.07.025","volume":"141","author":"Y Guo","year":"2016","unstructured":"Guo Y, Zhou IY, Chan S-T et al (2016) pH-sensitive MRI demarcates graded tissue acidification during acute stroke - pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI. Neuroimage 141:242\u2013249","journal-title":"Neuroimage"},{"key":"6248_CR25","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/mrm.26131","volume":"77","author":"D-H Lee","year":"2017","unstructured":"Lee D-H, Heo H-Y, Zhang K et al (2017) Quantitative assessment of the effects of water proton concentration and water T1 changes on amide proton transfer (APT) and nuclear overhauser enhancement (NOE) MRI: the origin of the APT imaging signal in brain tumor. Magn Reson Med 77:855\u2013863","journal-title":"Magn Reson Med"},{"key":"6248_CR26","doi-asserted-by":"publisher","first-page":"4408","DOI":"10.21037\/qims-21-250","volume":"11","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Wang X (2021) Amide proton transfer (APT) imaging-based study on the correlation between brain pH and voltage-gated proton channels in piglets after hypoxic-ischemic brain injury. Quant Imag Med Surg 11:4408\u20134417","journal-title":"Quant Imag Med Surg"},{"key":"6248_CR27","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1002\/mrm.20048","volume":"51","author":"J Zhou","year":"2004","unstructured":"Zhou J, Wilson DA, Sun PZ et al (2004) Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments. Magn Reson Med 51:945\u2013952","journal-title":"Magn Reson Med"},{"key":"6248_CR28","first-page":"929","volume":"35","author":"L Yang","year":"2020","unstructured":"Yang L, Zhao H, Cui H (2020) Treatment and new progress of neonatal hypoxic-ischemic brain damage. Histol Histopathol 35:929\u2013936","journal-title":"Histol Histopathol"},{"key":"6248_CR29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s13760-020-01308-3","volume":"120","author":"P Greco","year":"2020","unstructured":"Greco P, Nencini G, Piva I et al (2020) Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future. Acta Neurol Belg 120:277\u2013288","journal-title":"Acta Neurol Belg"},{"key":"6248_CR30","doi-asserted-by":"publisher","first-page":"996949","DOI":"10.3389\/fped.2022.996949","volume":"10","author":"S Chen","year":"2022","unstructured":"Chen S, Liu X, Lin J et al (2022) Application of amide proton transfer imaging for the diagnosis of neonatal hypoxic-ischemic encephalopathy. Front Pediatr 10:996949","journal-title":"Front Pediatr"},{"key":"6248_CR31","doi-asserted-by":"publisher","first-page":"108620","DOI":"10.1016\/j.ejrad.2019.07.021","volume":"119","author":"S Chen","year":"2019","unstructured":"Chen S, Liu X, Mei Y et al (2019) Early identification of neonatal mild hypoxic-ischemic encephalopathy by amide proton transfer magnetic resonance imaging: a pilot study. Eur J Radiol 119:108620","journal-title":"Eur J Radiol"},{"key":"6248_CR32","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3174\/ajnr.A5066","volume":"38","author":"Y Zheng","year":"2017","unstructured":"Zheng Y, Wang X-M (2017) Measurement of lactate content and amide proton transfer values in the basal ganglia of a neonatal piglet hypoxic-ischemic brain injury model using MRI. AJNR Am J Neuroradiol 38:827\u2013834","journal-title":"AJNR Am J Neuroradiol"},{"key":"6248_CR33","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s10571-017-0552-7","volume":"38","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Wang X (2018) The applicability of amide proton transfer imaging in the nervous system: focus on hypoxic-ischemic encephalopathy in the neonate. Cell Mol Neurobiol 38:797\u2013807","journal-title":"Cell Mol Neurobiol"},{"key":"6248_CR34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.pediatrneurol.2007.06.005","volume":"37","author":"JD Winter","year":"2007","unstructured":"Winter JD, Lee DS, Hung RM et al (2007) Apparent diffusion coefficient pseudonormalization time in neonatal hypoxic-ischemic encephalopathy. Pediatr Neurol 37:255\u2013262","journal-title":"Pediatr Neurol"},{"key":"6248_CR35","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000454856","volume":"39","author":"ME Lemmon","year":"2017","unstructured":"Lemmon ME, Wagner MW, Bosemani T et al (2017) Diffusion tensor imaging detects occult cerebellar injury in severe neonatal hypoxic-ischemic encephalopathy. Dev Neurosci 39:207\u2013214","journal-title":"Dev Neurosci"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-025-06248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-025-06248-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-025-06248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T13:40:08Z","timestamp":1751636408000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00247-025-06248-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":35,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["6248"],"URL":"https:\/\/doi.org\/10.1007\/s00247-025-06248-9","relation":{},"ISSN":["1432-1998"],"issn-type":[{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]},"assertion":[{"value":"8 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}