{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:47:47Z","timestamp":1782841667048,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Selcuk University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The standard method for diagnosing Meckel diverticulum and identifying ectopic gastric mucosa is <jats:sup>99 m<\/jats:sup>Tc-pertechnetate imaging. Premedication with H<jats:sub>2<\/jats:sub> receptor antagonists enhances the scan\u2019s sensitivity by reducing the washout of <jats:sup>99 m<\/jats:sup>Tc-pertechnetate activity from the intestinal lumen.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>After the withdrawal of ranitidine, we compared the efficacy of the proton pump inhibitor pantoprazole as an alternative premedication agent for <jats:sup>99 m<\/jats:sup>Tc-pertechnetate Meckel diverticulum imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods<\/jats:title>\n            <jats:p>This study assessed the scan quality of 141 children (aged 1\u00a0month to 204\u00a0months (median\u2009=\u200984\u00a0months)) who underwent Meckel scintigraphy over 10\u00a0years at a single institution. Before its withdrawal in December 2020, ranitidine was utilized for premedication, while pantoprazole was used thereafter. Therefore, patients were divided into two premedication groups: ranitidine (<jats:italic>n<\/jats:italic>\u2009=\u200988) and pantoprazole (<jats:italic>n<\/jats:italic>\u2009=\u200953). A high-quality scan was defined as having no <jats:sup>99 m<\/jats:sup>Tc-pertechnetate activity in the duodenal and other intestinal lumens. The effectiveness of pantoprazole in reducing <jats:sup>99 m<\/jats:sup>Tc-pertechnetate release in the duodenum and other intestinal lumens was compared to that of ranitidine. Differences in scan quality between the groups were analyzed using the two-proportion <jats:italic>Z<\/jats:italic>-test. In patients with positive scans, the lesion-to-background activity ratio of the Meckel diverticulum was measured and compared between the premedication groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Premedication with pantoprazole resulted in 47.2% of scans showing no <jats:sup>99 m<\/jats:sup>Tc-pertechnetate release, 37.7% with activity localized either in the duodenum or other intestine, and 15.1% exhibiting activity in both regions. In comparison, ranitidine resulted in 45.5% of scans with no <jats:sup>99 m<\/jats:sup>Tc-pertechnetate release, 40.9% with activity localized either in the duodenum or other intestine, and 13.6% showing activity in both regions. <jats:italic>P<\/jats:italic>-values were not found to be significant in all comparisons. Twelve scans were positive; all patients had Meckel diverticulum confirmed at surgery. For positive scans, the lesion-to-background activity ratio for the Meckel diverticulum was similar between the ranitidine and pantoprazole groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study demonstrates that pantoprazole is statistically non-inferior to ranitidine regarding scan quality and lesion-to-background activity ratios for Meckel diverticulum detection. Pantoprazole offers a reliable alternative for clinical protocols in the absence of ranitidine.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00247-025-06284-5","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T01:57:19Z","timestamp":1749866239000},"page":"1713-1718","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Premedication in pediatric Meckel scintigraphy: pantoprazole versus ranitidine for optimizing scan quality"],"prefix":"10.1007","volume":"55","author":[{"given":"Hasan","family":"\u00d6nner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve Ni\u0307da","family":"Calderon Tobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sar\u0131kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"\u00d6zcan S\u0131k\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fari\u0307se","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muslu Kazim","family":"K\u00f6rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonca","family":"Kara Gedi\u0307k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"6284_CR1","first-page":"421","volume":"9","author":"JF Meckel","year":"1809","unstructured":"Meckel JF (1809) Ueber die Divertikel am Darmkanal. 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