{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:40:54Z","timestamp":1792827654027,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"DOI":"10.1007\/s00247-026-06548-8","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:47:20Z","timestamp":1770886040000},"page":"843-855","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Contrast enema in Hirschsprung disease: radiological signs and clinical symptoms as predictors in a logistic regression model"],"prefix":"10.1007","volume":"56","author":[{"given":"Paulina","family":"Vargova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Izquierdo-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gutierrez-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diasol","family":"Villa-Vi\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Santinno-Tenorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Mayordomo-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Corona-Bellostas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"6548_CR1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13023-020-01362-3","volume":"15","author":"K Kyrklund","year":"2020","unstructured":"Kyrklund K, Sloots CEJ, de Blaauw I, Bj\u00f8rnland K, Rolle U, Cavalieri D et al (2020) ERNICA guidelines for the management of rectosigmoid Hirschsprung\u2019s disease. Orphanet J Rare Dis 15:164","journal-title":"Orphanet J Rare Dis"},{"key":"6548_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1590\/0102-6720201600030007","volume":"29","author":"M Peyvasteh","year":"2016","unstructured":"Peyvasteh M, Askarpour S, Ostadian N, Moghimi MR, Javaherizadeh H (2016) Diagnostic accuracy of barium enema findings in Hirschsprung\u2019s disease. ABCD Arq Bras Cir Dig (S\u00e3o Paulo) 29:155\u2013158","journal-title":"ABCD Arq Bras Cir Dig (S\u00e3o Paulo)"},{"key":"6548_CR3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1007\/s12098-017-2371-8","volume":"84","author":"K Das","year":"2017","unstructured":"Das K, Mohanty S (2017) Hirschsprung disease\u2014current diagnosis and management. Indian J Pediatr 84:618\u2013623","journal-title":"Indian J Pediatr"},{"key":"6548_CR4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1055\/s-0036-1593991","volume":"27","author":"A Zani","year":"2017","unstructured":"Zani A, Eaton S, Morini F, Puri P, Rintala R, van Heurn E et al (2017) European Paediatric Surgeons\u2019 Association survey on the management of Hirschsprung disease. Eur J Pediatr Surg 27:96\u2013101","journal-title":"Eur J Pediatr Surg"},{"key":"6548_CR5","doi-asserted-by":"publisher","first-page":"519.e11","DOI":"10.1016\/j.crad.2017.01.007","volume":"72","author":"TJ Hwang","year":"2017","unstructured":"Hwang TJ, Servaes S, Mattei P, Anupindi SA (2017) Radiologist performance in the interpretation of contrast enemas performed for Hirschsprung\u2019s disease in children >1 year of age. Clin Radiol 72:519.e11-519.e19","journal-title":"Clin Radiol"},{"key":"6548_CR6","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.jpedsurg.2015.03.019","volume":"50","author":"LR Putnam","year":"2015","unstructured":"Putnam LR, John SD, Greenfield SA, Kellagher CM, Austin MT, Lally KP et al (2015) The utility of the contrast enema in neonates with suspected Hirschsprung disease. J Pediatr Surg 50:963\u2013966","journal-title":"J Pediatr Surg"},{"key":"6548_CR7","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.jpedsurg.2006.12.031","volume":"42","author":"IR Diamond","year":"2007","unstructured":"Diamond IR, Casadiego G, Traubici J, Langer JC, Wales PW (2007) The contrast enema for Hirschsprung disease: predictors of a false-positive result. J Pediatr Surg 42:792\u2013795","journal-title":"J Pediatr Surg"},{"key":"6548_CR8","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1007\/s00247-020-04631-2","volume":"50","author":"SSC Vlok","year":"2020","unstructured":"Vlok SSC, Moore SW, Schubert PT, Pitcher RD (2020) Accuracy of colonic mucosal patterns at contrast enema for diagnosis of Hirschsprung disease. Pediatr Radiol 50:810\u2013816","journal-title":"Pediatr Radiol"},{"key":"6548_CR9","first-page":"e6339","volume":"11","author":"N Sajjad","year":"2019","unstructured":"Sajjad N, Hilal K, Khandwala K, Arshad M, Uddin N (2019) Usefulness of delayed films of contrast enema for detecting Hirschsprung\u2019s disease. Cureus 11:e6339","journal-title":"Cureus"},{"key":"6548_CR10","doi-asserted-by":"publisher","DOI":"10.5812\/iranjradiol.12451","volume":"12","author":"M Alehossein","year":"2015","unstructured":"Alehossein M, Roohi A, Pourgholami M, Mollaeian M, Salamati P (2015) Diagnostic accuracy of radiologic scoring system for evaluation of suspicious Hirschsprung disease in children. Iran J Radiol 12:e12451","journal-title":"Iran J Radiol"},{"key":"6548_CR11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/ajcp\/aqac141","volume":"159","author":"K Matsukuma","year":"2023","unstructured":"Matsukuma K, Gui D, Saadai P (2023) Hirschsprung disease for the practicing surgical pathologist. Am J Clin Pathol 159:228\u2013241","journal-title":"Am J Clin Pathol"},{"key":"6548_CR12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12519-015-0068-5","volume":"12","author":"ED Muise","year":"2016","unstructured":"Muise ED, Cowles RA (2016) Rectal biopsy for Hirschsprung\u2019s disease: a review of techniques, pathology, and complications. World J Pediatr 12:135\u2013141","journal-title":"World J Pediatr"},{"key":"6548_CR13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2214\/ajr.167.2.8686640","volume":"167","author":"AN O\u2019Donovan","year":"1996","unstructured":"O\u2019Donovan AN, Haberman S, Hunter TB (1996) Diagnosis of Hirschsprung disease. AJR Am J Roentgenol 167:517\u2013520","journal-title":"AJR Am J Roentgenol"},{"key":"6548_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9060678","volume":"9","author":"J Khorana","year":"2021","unstructured":"Khorana J, Phiromkanchanasak P, Kumsattra J, Klinoun S, Aksorn S, Chantakhow S et al (2021) Development of clinical referral score model for early diagnosis of Hirschsprung\u2019s disease in suspected pediatric patients. Healthcare 9:678","journal-title":"Healthcare"},{"key":"6548_CR15","volume":"14","author":"A Manzoor","year":"2022","unstructured":"Manzoor A, Talat N, Adnan HM, Zia MW, Aziz MA, Ahmed E (2022) Contrast enema: solving diagnostic dilemmas in neonates with lower intestinal obstruction. Cureus 14:e23458","journal-title":"Cureus"},{"key":"6548_CR16","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00247-004-1292-7","volume":"34","author":"DH Jamieson","year":"2004","unstructured":"Jamieson DH, Dundas SE, Al Belushi S, Cooper M, Blair GK (2004) Does the transition zone reliably delineate aganglionic bowel in Hirschsprung\u2019s disease? Pediatr Radiol 34:811\u2013815","journal-title":"Pediatr Radiol"},{"key":"6548_CR17","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1007\/s00247-008-0952-4","volume":"38","author":"E Stranzinger","year":"2008","unstructured":"Stranzinger E, DiPietro MA, Teitelbaum DH, Strouse PJ (2008) Imaging of total colonic Hirschsprung disease. Pediatr Radiol 38:1162\u20131170","journal-title":"Pediatr Radiol"},{"key":"6548_CR18","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00383-009-2408-9","volume":"25","author":"SW Moore","year":"2009","unstructured":"Moore SW (2009) Total colonic aganglionosis and Hirschsprung\u2019s disease: shades of the same or different? Pediatr Surg Int 25:659\u2013666","journal-title":"Pediatr Surg Int"},{"key":"6548_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2013.03.001","volume":"162","author":"NE Butler Tjaden","year":"2013","unstructured":"Butler Tjaden NE, Trainor PA (2013) The developmental etiology and pathogenesis of Hirschsprung disease. Transl Res 162:1\u201315","journal-title":"Transl Res"},{"key":"6548_CR20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1177\/1093526619892351","volume":"23","author":"L Ambartsumyan","year":"2020","unstructured":"Ambartsumyan L, Smith C, Kapur RP (2020) Diagnosis of Hirschsprung disease. Pediatr Dev Pathol 23:8\u201322","journal-title":"Pediatr Dev Pathol"},{"key":"6548_CR21","doi-asserted-by":"publisher","first-page":"212","DOI":"10.21037\/tp-23-497","volume":"13","author":"YH Huang","year":"2024","unstructured":"Huang YH, Wan R, Yang Y, Jin Y, Lin Q, Liu Z et al (2024) Artificial intelligence-powered early identification of refractory constipation in children. Transl Pediatr 13:212\u2013223","journal-title":"Transl Pediatr"},{"key":"6548_CR22","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1055\/s-0030-1262842","volume":"20","author":"JZ Chen","year":"2010","unstructured":"Chen JZ, Jamieson DH, Skarsgard ED (2010) Does pre-biopsy contrast enema delay the diagnosis of long-segment Hirschsprung\u2019s disease? Eur J Pediatr Surg 20:375\u2013378","journal-title":"Eur J Pediatr Surg"},{"key":"6548_CR23","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/bdra.23016","volume":"94","author":"KE Best","year":"2012","unstructured":"Best KE, Glinianaia SV, Bythell M, Rankin J (2012) Hirschsprung\u2019s disease in the North of England: prevalence, associated anomalies, and survival. Birth Defects Res A Clin Mol Teratol 94:477\u2013480","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"6548_CR24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00383-002-0842-z","volume":"19","author":"SJ Singh","year":"2003","unstructured":"Singh SJ, Croaker GDH, Manglick P, Wong CL, Athanasakos H, Elliott E et al (2003) Hirschsprung\u2019s disease: the Australian paediatric surveillance unit\u2019s experience. Pediatr Surg Int 19:247\u2013250","journal-title":"Pediatr Surg Int"},{"key":"6548_CR25","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/jpsu.2003.50165","volume":"38","author":"BM Proctor","year":"2003","unstructured":"Proctor BM, Traubici J, Langer JC, Gibbs DL, Ein SH, Daneman A et al (2003) Correlation between radiographic transition zone and level of aganglionosis in Hirschsprung\u2019s disease: implications for surgical approach. J Pediatr Surg 38:775\u2013778","journal-title":"J Pediatr Surg"},{"key":"6548_CR26","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00383-012-3094-6","volume":"28","author":"CO Muller","year":"2012","unstructured":"Muller CO, Mignot C, Belarbi N, Berrebi D, Bonnard A (2012) Does the radiographic transition zone correlate with the level of aganglionosis on the specimen in Hirschsprung\u2019s disease? Pediatr Surg Int 28:597\u2013601","journal-title":"Pediatr Surg Int"},{"key":"6548_CR27","first-page":"207","volume":"26","author":"G Frongia","year":"2016","unstructured":"Frongia G, G\u00fcnther P, Schenk JP, Strube K, Kessler M, Mehrabi A et al (2016) Contrast enema for Hirschsprung disease investigation: diagnostic accuracy and validity for subsequent diagnostic and surgical planning. Eur J Pediatr Surg 26:207\u2013214","journal-title":"Eur J Pediatr Surg"},{"key":"6548_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/BF01042242","volume":"14","author":"JF De Campo","year":"1984","unstructured":"De Campo JF, Mayne V, Boldt DW, De Campo M (1984) Radiological findings in total aganglionosis coli. Pediatr Radiol 14:205\u2013209","journal-title":"Pediatr Radiol"},{"key":"6548_CR29","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s00247-016-3746-0","volume":"47","author":"IJN Koppen","year":"2017","unstructured":"Koppen IJN, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN et al (2017) Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol 47:306\u2013312","journal-title":"Pediatr Radiol"},{"key":"6548_CR30","doi-asserted-by":"crossref","unstructured":"Vargova P, Varga M, Izquierdo-Hern\u00e1ndez B, Gutierrez-Alonso C, Gonzalez-Esgueda A, Cobos-Hern\u00e1ndez MV et al (2026) Artificial intelligence enhances diagnostic accuracy of contrast enemas in Hirschsprung disease compared to clinical experts. Eur J Pediatr Surg 36(1):3\u201312","DOI":"10.1055\/a-2646-2052"},{"key":"6548_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00383-014-3632-5","volume":"31","author":"CWY Wong","year":"2015","unstructured":"Wong CWY, Lau CT, Chung PHY, Lam WMW, Wong KKY, Tam PKH (2015) The value of the 24-h delayed abdominal radiograph of barium enema in the diagnosis of Hirschsprung\u2019s disease. Pediatr Surg Int 31:11\u201315","journal-title":"Pediatr Surg Int"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-026-06548-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-026-06548-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-026-06548-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:19:02Z","timestamp":1779358742000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00247-026-06548-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["6548"],"URL":"https:\/\/doi.org\/10.1007\/s00247-026-06548-8","relation":{},"ISSN":["1432-1998"],"issn-type":[{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"26 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"\u00a0None","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}