{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:52:22Z","timestamp":1792702342833,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"DOI":"10.1007\/s00247-026-06706-y","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:54:07Z","timestamp":1783428847000},"page":"2431-2442","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ferumoxytol dose optimization for three-dimensional whole-heart magnetic resonance imaging in patients with congenital heart disease"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5861-1026","authenticated-orcid":false,"given":"Sukran","family":"Erdem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"El Jerbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Thai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasya","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F.","family":"Greil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Alsaied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Dzelebdzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"6706_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fped.2017.00036","volume":"5","author":"G Greil","year":"2017","unstructured":"Greil G, Tandon AA, Silva Vieira M, Hussain T (2017) 3D Whole heart imaging for congenital heart disease. Front Pediatr 5:36","journal-title":"Front Pediatr"},{"key":"6706_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1161\/01.CIR.0000134282.35183.AD","volume":"110","author":"TS S\u00f8rensen","year":"2004","unstructured":"S\u00f8rensen TS, K\u00f6rperich H, Greil GF et al (2004) Operator-independent isotropic three-dimensional magnetic resonance imaging for morphology in congenital heart disease: a validation study. Circulation 110:163\u2013169","journal-title":"Circulation"},{"key":"6706_CR3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1532-429X-15-51","volume":"15","author":"S Fratz","year":"2013","unstructured":"Fratz S, Chung T, Greil GF et al (2013) Guidelines and protocols for cardiovascular magnetic resonance in children and adults with congenital heart disease: SCMR expert consensus group on congenital heart disease. J Cardiovasc Magn Reson 15:51","journal-title":"J Cardiovasc Magn Reson"},{"key":"6706_CR4","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1016\/j.ejrad.2015.06.030","volume":"84","author":"JA Febbo","year":"2015","unstructured":"Febbo JA, Galizia MS, Murphy IG et al (2015) Congenital heart disease in adults: quantitative and qualitative evaluation of IR FLASH and IR SSFP MRA techniques using a blood pool contrast agent in the steady state and comparison to first pass MRA. Eur J Radiol 84:1921\u20131929","journal-title":"Eur J Radiol"},{"key":"6706_CR5","doi-asserted-by":"publisher","first-page":"5714","DOI":"10.1039\/C7TB01241A","volume":"5","author":"MM Meloni","year":"2017","unstructured":"Meloni MM, Barton S, Xu L et al (2017) Contrast agents for cardiovascular magnetic resonance imaging: an overview. J Mater Chem B 5:5714\u20135725","journal-title":"J Mater Chem B"},{"key":"6706_CR6","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s00247-021-05098-5","volume":"52","author":"HE Daldrup-Link","year":"2022","unstructured":"Daldrup-Link HE, Theruvath AJ, Rashidi A et al (2022) How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol. Pediatr Radiol 52:354\u2013366","journal-title":"Pediatr Radiol"},{"key":"6706_CR7","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1002\/mrm.26151","volume":"75","author":"SS Vasanawala","year":"2016","unstructured":"Vasanawala SS, Nguyen K-L, Hope MD et al (2016) Safety and technique of ferumoxytol administration for MRI. Magn Reson Med 75:2107\u20132111","journal-title":"Magn Reson Med"},{"key":"6706_CR8","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1007\/s00247-023-05778-4","volume":"53","author":"A Dasi","year":"2023","unstructured":"Dasi A, Kring DN, Selvaraj B et al (2023) Brand ferumoxytol vs. generic ferumoxytol comparison across two dosing regimens: a cardiac MRI image quality study. Pediatr Radiol 53:2622\u20132632","journal-title":"Pediatr Radiol"},{"key":"6706_CR9","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2214\/ajr.182.3.1820609","volume":"182","author":"J Bogaert","year":"2004","unstructured":"Bogaert J, Taylor AM, Van Kerkhove F et al (2004) Use of inversion recovery contrast-enhanced MRI for cardiac imaging: spectrum of applications. Am J Roentgenol 182:609\u2013615","journal-title":"Am J Roentgenol"},{"key":"6706_CR10","doi-asserted-by":"publisher","first-page":"P22","DOI":"10.1186\/1532-429X-18-S1-P22","volume":"18","author":"VM Ferreira","year":"2016","unstructured":"Ferreira VM, Liu A, Marini C et al (2016) Post-contrast T1-mapping provides a novel approach to optimal myocardial nulling for late gadolinium enhancement imaging: a quantitative prescription for the correct TI without the guesswork. J Cardiovasc Magn Reson 18:P22","journal-title":"J Cardiovasc Magn Reson"},{"key":"6706_CR11","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.2214\/ajr.168.5.9129447","volume":"168","author":"MV McConnell","year":"1997","unstructured":"McConnell MV, Khasgiwala VC, Savord BJ et al (1997) Comparison of respiratory suppression methods and navigator locations for MR coronary angiography. Am J Roentgenol 168:1369\u20131375","journal-title":"Am J Roentgenol"},{"key":"6706_CR12","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1148\/radiol.11102327","volume":"260","author":"MR Makowski","year":"2011","unstructured":"Makowski MR, Wiethoff AJ, Uribe S et al (2011) Congenital heart disease: cardiovascular MR imaging by using an intravascular blood pool contrast agent. Radiology 260:680\u2013688","journal-title":"Radiology"},{"key":"6706_CR13","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1148\/radiol.12111700","volume":"263","author":"T Hussain","year":"2012","unstructured":"Hussain T, Lossnitzer D, Bellsham-Revell H et al (2012) Three-dimensional dual-phase whole-heart Mr imaging: clinical implications for congenital heart disease 1. Radiology 263:547\u2013554","journal-title":"Radiology"},{"key":"6706_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1532-429X-13-51","volume":"13","author":"HN Ntsinjana","year":"2011","unstructured":"Ntsinjana HN, Hughes ML, Taylor AM (2011) The role of cardiovascular magnetic resonance in pediatric congenital heart disease. J Cardiovasc Magn Reson 13:51","journal-title":"J Cardiovasc Magn Reson"},{"key":"6706_CR15","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.3390\/children9121810","volume":"9","author":"P Renella","year":"2022","unstructured":"Renella P, Li J, Prosper AE, Finn JP, Nguyen K-L (2022) Ferumoxytol-enhanced cardiac magnetic resonance angiography and 4D flow: safety and utility in pediatric and adult congenital heart disease. Children 9:1810","journal-title":"Children"},{"key":"6706_CR16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/jmri.20235","volume":"21","author":"W Li","year":"2005","unstructured":"Li W, Tutton S, Vu AT et al (2005) First-pass contrast-enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)-based blood pool agent. J Magn Reson Imaging 21:46\u201352","journal-title":"J Magn Reson Imaging"},{"key":"6706_CR17","doi-asserted-by":"publisher","first-page":"3543","DOI":"10.1007\/s00330-019-06137-4","volume":"29","author":"S Stoumpos","year":"2019","unstructured":"Stoumpos S, Hennessy M, Vesey AT et al (2019) Ferumoxytol magnetic resonance angiography: a dose-finding study in patients with chronic kidney disease. Eur Radiol 29:3543\u20133552","journal-title":"Eur Radiol"},{"key":"6706_CR18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/RLI.0000000000000434","volume":"53","author":"G Knobloch","year":"2018","unstructured":"Knobloch G, Colgan T, Wiens CN et al (2018) Relaxivity of ferumoxytol at 1.5 T and 3.0 T. Invest Radiol 53:257\u2013263","journal-title":"Invest Radiol"},{"key":"6706_CR19","doi-asserted-by":"publisher","first-page":"e12667","DOI":"10.5812\/iranjradiol.12667","volume":"11","author":"H Saharkhiz","year":"2014","unstructured":"Saharkhiz H, Gharehaghaji N, Nazarpoor M et al (2014) The Effect of Inversion Time on the Relationship Between Iron Oxide Nanoparticle Concentration and Signal Intensity in T1-Weighted MR Images. Iranian J Radiol 11:e12667","journal-title":"Iranian J Radiol"},{"key":"6706_CR20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1148\/radiol.10100828","volume":"259","author":"T Tangcharoen","year":"2011","unstructured":"Tangcharoen T, Bell A, Hegde S et al (2011) Detection of coronary artery anomalies in infants and young children with congenital heart disease by using MR imaging. Radiology 259:240\u2013247","journal-title":"Radiology"},{"key":"6706_CR21","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/jmri.10078","volume":"15","author":"P B\u00f6rnert","year":"2002","unstructured":"B\u00f6rnert P, Stuber M, Botnar RM et al (2002) Comparison of fat suppression strategies in 3D spiral coronary magnetic resonance angiography. J Magn Reson Imaging 15:462\u2013466","journal-title":"J Magn Reson Imaging"},{"key":"6706_CR22","doi-asserted-by":"publisher","first-page":"395","DOI":"10.4236\/jbise.2013.63A050","volume":"06","author":"MM Ribeiro","year":"2013","unstructured":"Ribeiro MM, Rumor L, Oliveira M et al (2013) STIR, SPIR and SPAIR techniques in magnetic resonance of the breast: a comparative study. J Biomed Sci Eng 06:395\u2013402","journal-title":"J Biomed Sci Eng"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-026-06706-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-026-06706-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-026-06706-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:10:49Z","timestamp":1792023049000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-026-06706-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":22,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["6706"],"URL":"https:\/\/doi.org\/10.1007\/s00247-026-06706-y","relation":{},"ISSN":["1432-1998"],"issn-type":[{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"6 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}