{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:09:52Z","timestamp":1788844192577,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Radiol"],"DOI":"10.1007\/s00247-026-06766-0","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:22:36Z","timestamp":1788841356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between protocol-related operational factors, MRI duration, and propofol exposure in pediatric MRI"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-411X","authenticated-orcid":false,"given":"Sergio","family":"Valencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5687-4186","authenticated-orcid":false,"given":"Suely","family":"Fazio Ferracioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-4244","authenticated-orcid":false,"given":"Camilo","family":"Jaimes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Gee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"6766_CR1","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1007\/s00247-016-3613-z","volume":"46","author":"C Jaimes","year":"2016","unstructured":"Jaimes C, Gee MS (2016) Strategies to minimize sedation in pediatric body magnetic resonance imaging. Pediatr Radiol 46:916\u2013927","journal-title":"Pediatr Radiol"},{"key":"6766_CR2","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1542\/peds.2006-0313","volume":"118","author":"JP Cravero","year":"2006","unstructured":"Cravero JP, Blike GT, Beach M et al (2006) Incidence and nature of adverse events during pediatric sedation\/anesthesia for procedures outside the operating room: report from the Pediatric Sedation Research Consortium. Pediatrics 118:1087\u20131096","journal-title":"Pediatrics"},{"key":"6766_CR3","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1007\/s00247-021-05044-5","volume":"51","author":"M Artunduaga","year":"2021","unstructured":"Artunduaga M, Liu CA, Morin CE et al (2021) Safety challenges related to the use of sedation and general anesthesia in pediatric patients undergoing magnetic resonance imaging examinations. Pediatr Radiol 51:724\u2013735","journal-title":"Pediatr Radiol"},{"key":"6766_CR4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.jpeds.2011.11.003","volume":"160","author":"M Srinivasan","year":"2012","unstructured":"Srinivasan M, Turmelle M, DePalma LM et al (2012) Procedural sedation for diagnostic imaging in children by pediatric hospitalists using propofol: analysis of the nature, frequency, and predictors of adverse events and interventions. J Pediatr 160:801-806.e1","journal-title":"J Pediatr"},{"key":"6766_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-025-03376-5","volume":"25","author":"P Armeni","year":"2025","unstructured":"Armeni P, Costa F, Fornaro G et al (2025) The economic burden of anesthetic-related adverse events: a systematic review and empirical analysis. BMC Anesthesiol 25:547","journal-title":"BMC Anesthesiol"},{"key":"6766_CR6","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s00247-011-2115-2","volume":"41","author":"TL Slovis","year":"2011","unstructured":"Slovis TL (2011) Sedation and anesthesia issues in pediatric imaging. Pediatr Radiol 41:514\u2013516","journal-title":"Pediatr Radiol"},{"key":"6766_CR7","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/jmri.28392","volume":"57","author":"MD Mallory","year":"2023","unstructured":"Mallory MD, Travers C, Cravero JP et al (2023) Pediatric sedation\/anesthesia for MRI: results from the Pediatric Sedation Research Consortium. Magn Reson Imaging 57:1106\u20131113","journal-title":"Magn Reson Imaging"},{"key":"6766_CR8","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.jacr.2017.01.025","volume":"14","author":"JC Uffman","year":"2017","unstructured":"Uffman JC, Tumin D, Raman V et al (2017) MRI utilization and the associated use of sedation and anesthesia in a pediatric ACO. J Am Coll Radiol 14:924\u2013930","journal-title":"J Am Coll Radiol"},{"key":"6766_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48724-x","volume":"9","author":"S Kim","year":"2019","unstructured":"Kim S, Hahn S, Jang M et al (2019) Evaluation of the safety of using propofol for paediatric procedural sedation: a systematic review and meta-analysis. Sci Rep 9:12245","journal-title":"Sci Rep"},{"key":"6766_CR10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/bja\/aen153","volume":"101","author":"A-M Machata","year":"2008","unstructured":"Machata A-M, Willschke H, Kabon B et al (2008) Propofol-based sedation regimen for infants and children undergoing ambulatory magnetic resonance imaging. Br J Anaesth 101:239\u2013243","journal-title":"Br J Anaesth"},{"key":"6766_CR11","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s40263-015-0259-6","volume":"29","author":"V Chidambaran","year":"2015","unstructured":"Chidambaran V, Costandi A, D\u2019Mello A (2015) Propofol: a review of its role in pediatric anesthesia and sedation. CNS Drugs 29:543\u2013563","journal-title":"CNS Drugs"},{"key":"6766_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00247-017-3987-6","volume":"48","author":"R Ahmad","year":"2018","unstructured":"Ahmad R, Hu HH, Krishnamurthy R, Krishnamurthy R (2018) Reducing sedation for pediatric body MRI using accelerated and abbreviated imaging protocols. Pediatr Radiol 48:37\u201349","journal-title":"Pediatr Radiol"},{"key":"6766_CR13","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1148\/rg.2020190112","volume":"40","author":"BM Kozak","year":"2020","unstructured":"Kozak BM, Jaimes C, Kirsch J, Gee MS (2020) MRI techniques to decrease imaging times in children. Radiographics 40:485\u2013502","journal-title":"Radiographics"},{"key":"6766_CR14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s00247-017-3785-1","volume":"48","author":"MJ Barkovich","year":"2018","unstructured":"Barkovich MJ, Xu D, Desikan RS et al (2018) Pediatric neuro MRI: tricks to minimize sedation. Pediatr Radiol 48:50\u201355","journal-title":"Pediatr Radiol"},{"key":"6766_CR15","doi-asserted-by":"publisher","first-page":"799","DOI":"10.2214\/AJR.20.23601","volume":"216","author":"F Machado-Rivas","year":"2021","unstructured":"Machado-Rivas F, Leitman E, Jaimes C et al (2021) Predictors of anesthetic exposure in pediatric MRI. AJR Am J Roentgenol 216:799\u2013805","journal-title":"AJR Am J Roentgenol"},{"key":"6766_CR16","doi-asserted-by":"publisher","DOI":"10.1177\/0300060521990992","volume":"49","author":"JY Min","year":"2021","unstructured":"Min JY, Lee J-R, Kang YS et al (2021) Pediatric characteristics and the dose of propofol for sedation during radiological examinations: a retrospective analysis. J Int Med Res 49:0300060521990992","journal-title":"J Int Med Res"},{"key":"6766_CR17","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1213\/ANE.0000000000006196","volume":"136","author":"H Van Dijk","year":"2023","unstructured":"Van Dijk H, Hendriks MP, Van Eck-Smaling MM et al (2023) Age-stratified propofol dosage for pediatric procedural sedation and analgesia. Anesth Analg 136:551\u2013558","journal-title":"Anesth Analg"},{"key":"6766_CR18","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1007\/s00330-012-2500-8","volume":"22","author":"JM Wardlaw","year":"2012","unstructured":"The SINAPSE Collaborative Group, Wardlaw JM, Brindle W et al (2012) A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research. Eur Radiol 22:2295\u20132303","journal-title":"Eur Radiol"},{"key":"6766_CR19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00247-017-3871-4","volume":"48","author":"K Barton","year":"2018","unstructured":"Barton K, Nickerson JP, Higgins T, Williams RK (2018) Pediatric anesthesia and neurotoxicity: what the radiologist needs to know. Pediatr Radiol 48:31\u201336","journal-title":"Pediatr Radiol"},{"key":"6766_CR20","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/S0140-6736(18)32485-1","volume":"393","author":"ME McCann","year":"2019","unstructured":"McCann ME, De Graaff JC, Dorris L et al (2019) Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet 393:664\u2013677","journal-title":"Lancet"},{"key":"6766_CR21","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1001\/jama.2016.6967","volume":"315","author":"LS Sun","year":"2016","unstructured":"Sun LS, Li G, Miller TLK et al (2016) Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood. JAMA 315:2312","journal-title":"JAMA"},{"key":"6766_CR22","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s00247-017-3989-4","volume":"48","author":"C Jaimes","year":"2018","unstructured":"Jaimes C, Murcia DJ, Miguel K et al (2018) Identification of quality improvement areas in pediatric MRI from analysis of patient safety reports. Pediatr Radiol 48:66\u201373","journal-title":"Pediatr Radiol"},{"key":"6766_CR23","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1200\/JCO.23.01989","volume":"42","author":"S Alexander","year":"2024","unstructured":"Alexander S, Kairalla JA, Gupta S et al (2024) Impact of propofol exposure on neurocognitive outcomes in children with high-risk B ALL: a Children\u2019s Oncology Group study. JCO 42:2671\u20132679","journal-title":"JCO"},{"key":"6766_CR24","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/pan.14225","volume":"31","author":"AE Vinson","year":"2021","unstructured":"Vinson AE, Peyton J, Kordun A et al (2021) Trends in pediatric MRI sedation\/anesthesia at a tertiary medical center over time. Paediatr Anaesth 31:953\u2013961","journal-title":"Paediatr Anaesth"}],"container-title":["Pediatric Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-026-06766-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00247-026-06766-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00247-026-06766-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:22:37Z","timestamp":1788841357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00247-026-06766-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":24,"alternative-id":["6766"],"URL":"https:\/\/doi.org\/10.1007\/s00247-026-06766-0","relation":{},"ISSN":["1432-1998"],"issn-type":[{"value":"1432-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"4 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This retrospective study was approved by the Massachusetts General Hospital Institutional Review Board and was conducted in accordance with the principles of the Declaration of Helsinki and applicable institutional regulations. The requirement for informed consent was waived by the Massachusetts General Hospital Institutional Review Board because of the retrospective nature of the study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}