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The analysis involved 58 strains of <jats:italic>Escherichia coli<\/jats:italic> and 61 strains of enterococci. Antibiotic resistance profiles were prepared in accordance with the recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). The results indicated a correlation between the location of a sampling site and the concentration of faecal bacteria. The highest average concentrations were recorded at the site located in the city centre, where the river is used mainly for recreation. Antibiotic resistance profiles showed that <jats:italic>Escherichia coli<\/jats:italic> had 100% sensitivity to tigecycline, levofloxacin and imipenem. The highest percentaage of strains (17%) were resistant to piperacillin. Enterococci were 100% sensitive to levofloxacin. No strains were vancomycin-resistant (VRE). The highest percentage of strains was resistant to imipenem (23%), and the lowest, to ampicillin (2%). The spatio-temporal distribution of antibiotic-resistant strains (ARS) indicated a high concentration of drug-resistant <jats:italic>Escherichia coli<\/jats:italic> (47%) in the summer season at the sampling site located in the last part of the river. At the same time, drug resistance in enterococci increased along the river course and was considerably higher in spring. There were no significant relationships between physico-chemical parameters of water and the levels of faecal bacteria. On the other hand, strong relationships were observed between the percentage of strains showing resistance to the applied antibiotics and physico-chemical and biological parameters of water. The percentage of antibiotic resistant strains of <jats:italic>Escherichia coli<\/jats:italic> was negatively correlated with dissolved oxygen concentration (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.9; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and BOD<jats:sub>5<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.85; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The percentage of antibiotic resistant strains of enterococci was most strongly correlated with water pH (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.92; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>","DOI":"10.1007\/s00248-020-01624-4","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:27:51Z","timestamp":1603585671000},"page":"592-600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Spread Patterns of Antibiotic Resistance in Faecal Indicator Bacteria Contaminating an Urbanized Section of the Brda River"],"prefix":"10.1007","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-8423","authenticated-orcid":false,"given":"\u0141ukasz","family":"Kubera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"1624_CR1","doi-asserted-by":"publisher","unstructured":"Woli\u0144ska D, S\u0142awi\u0144ski K (2017) Significance changes of a river for urban space creation on the example of Cheonggyecheon stream in Seul. 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