{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:44:49Z","timestamp":1777344289364,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunogenetics"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s00251-015-0828-3","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T23:38:37Z","timestamp":1425080317000},"page":"203-209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["KIR2DS5 in the presence of HLA-C C2 protects against endometriosis"],"prefix":"10.1007","volume":"67","author":[{"given":"Izabela","family":"Nowak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"P\u0142oski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Barcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Dziunycz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Kami\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u017cyna","family":"Kostrzewa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Milewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr I.","family":"Roszkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Senitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Malejczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ku\u015bnierczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"828_CR1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/1297-9686-35-6-513","volume":"35","author":"JM Abdallah","year":"2003","unstructured":"Abdallah JM, Goffinet B, Cierco-Ayrolles C, Perez-Enciso M (2003) Linkage disequilibrium fine mapping of quantitative trait loci: a simulation study. Genet Sel Evol 35:513\u2013532","journal-title":"Genet Sel Evol"},{"key":"828_CR2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0015-0282(16)48430-X","volume":"43","author":"American Fertility Society","year":"1985","unstructured":"American Fertility Society (1985) Revised American Fertility Society classification of endometriosis. Fertil Steril 43:351\u2013352","journal-title":"Fertil Steril"},{"key":"828_CR3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1034\/j.1600-0897.2003.00042.x","volume":"50","author":"M Berkkanoglu","year":"2003","unstructured":"Berkkanoglu M, Arici A (2003) Immunology and endometriosis. Am J Reprod Immunol 50:48\u201359","journal-title":"Am J Reprod Immunol"},{"key":"828_CR4","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1093\/nar\/gkl520","volume":"34","author":"K Bhasi","year":"2006","unstructured":"Bhasi K, Zhang L, Brazeau D, Zhang A, Ramanathan M (2006) Information-theoretic identification of predictive SNPs and supervised visualization of genome-wide association studies. Nucleic Acids Res 34:e101","journal-title":"Nucleic Acids Res"},{"key":"828_CR5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","volume":"98","author":"RO Burney","year":"2012","unstructured":"Burney RO, Giudice LC (2012) Pathogenesis and pathophysiology of endometriosis. Fertil Steril 98:511\u2013519","journal-title":"Fertil Steril"},{"key":"828_CR6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/gene.2013.58","volume":"15","author":"K Czaja","year":"2014","unstructured":"Czaja K, Borer AS, Schmied L, Terszowski G, Stern M, Gonzalez A (2014) A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs. Genes Immun 15:33\u201337","journal-title":"Genes Immun"},{"key":"828_CR7","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1002\/eji.200838434","volume":"38","author":"M Della Chiesa","year":"2008","unstructured":"Della Chiesa M, Romeo E, Falco M, Balsamo M, Augugliaro R, Moretta L (2008) Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function. Eur J Immunol 38:2284\u20132289","journal-title":"Eur J Immunol"},{"key":"828_CR8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bpobgyn.2004.02.001","volume":"18","author":"WP Dmowski","year":"2004","unstructured":"Dmowski WP, Braun DP (2004) Immunology of endometriosis. Best Pract Res Clin Obstet Gynaecol 18:245\u2013263","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"828_CR9","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/humrep\/det457","volume":"29","author":"GAJ Dunselman","year":"2014","unstructured":"Dunselman GAJ, Vermeulen N, Becker C et al (2014) ESHRE guideline: management of women with endometriosis. Hum Reprod 29:400\u2013412","journal-title":"Hum Reprod"},{"key":"828_CR10","first-page":"921","volume":"12","author":"L Excoffier","year":"1995","unstructured":"Excoffier L, Slatkin M (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 12:921\u2013927","journal-title":"Mol Biol Evol"},{"key":"828_CR11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/tan.12262","volume":"82","author":"M Falco","year":"2013","unstructured":"Falco M, Moretta L, Moretta A, Bottino C (2013) KIR and KIR ligand polymorphism: a new area for clinical applications? Tissue Antigens 82:363\u2013373","journal-title":"Tissue Antigens"},{"key":"828_CR12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-1759(98)00126-4","volume":"218","author":"C Frohn","year":"1998","unstructured":"Frohn C, Schlenke P, Ebel B, Dannenberg C, Bein G, Kitchner H (1998) DNA typing for natural killer cell inhibiting HLA-Cw groups NK1 and NK2 by PCR-SSP. J Immunol Methods 218:155\u2013160","journal-title":"J Immunol Methods"},{"issue":"Database issue","key":"828_CR13","doi-asserted-by":"crossref","first-page":"D784","DOI":"10.1093\/nar\/gku1166","volume":"43","author":"FF Gonzalez-Galarza","year":"2015","unstructured":"Gonzalez-Galarza FF, Christmas S, Middleton D, Jones AR (2015) Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Res 43(Database issue):D784\u2013D788","journal-title":"Nucleic Acids Res"},{"key":"828_CR14","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1084\/jem.20091010","volume":"206","author":"T Graef","year":"2009","unstructured":"Graef T, Moesta AK, Norman PJ, Abi-Rached L, Vago L, Older Aguilar AM (2009) KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C. J Exp Med 206:2557\u20132572","journal-title":"J Exp Med"},{"key":"828_CR15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fertnstert.2008.02.093","volume":"90","author":"S Gupta","year":"2008","unstructured":"Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A (2008) Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril 90:247\u2013257","journal-title":"Fertil Steril"},{"key":"828_CR16","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1084\/jem.20041214","volume":"200","author":"SE Hiby","year":"2004","unstructured":"Hiby SE, Walker JJ, O\u2019Shaughnessy KM, Redman CW, Carrington M, Trowsdale J (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 200:957\u2013965","journal-title":"J Exp Med"},{"key":"828_CR17","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.humimm.2009.04.028","volume":"70","author":"L Hou","year":"2009","unstructured":"Hou L, Chen M, Jiang B, Kariyawasam K, Ng J, Hurley CK (2009) In contrast to other stimulatory natural killer cell immunoglobulin-like receptor loci, several KIR2DS5 alleles predominate in African Americans. Hum Immunol 70:733\u2013737","journal-title":"Hum Immunol"},{"key":"828_CR18","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1101\/gr.137976.112","volume":"22","author":"J Jiang","year":"2012","unstructured":"Jiang J, Johnson C, Jayaraman J, Simecek N, Noble J, Moffatt MF (2012) Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors. Genome Res 22:1845\u20131854","journal-title":"Genome Res"},{"key":"828_CR19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1600-0897.2007.00533.x","volume":"58","author":"J Kitawaki","year":"2007","unstructured":"Kitawaki J, Xu B, Ishihara H, Fukui M, Hasegawa G, Nakamura N (2007) Association of killer cell immunoglobulin-like receptor genotypes with susceptibility to endometriosis. Am J Reprod Immunol 58:481\u2013486","journal-title":"Am J Reprod Immunol"},{"key":"828_CR20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.smim.2008.06.003","volume":"20","author":"S Kulkarni","year":"2008","unstructured":"Kulkarni S, Martin MP, Carrington M (2008) The Yin and Yang of HLA and KIR in human disease. Semin Immunol 20:343\u2013352","journal-title":"Semin Immunol"},{"key":"828_CR21","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.4049\/jimmunol.174.10.6540","volume":"174","author":"W Leung","year":"2005","unstructured":"Leung W, Iyengar R, Triplett B, Turner V, Behm FG, Holladay MS (2005) Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. J Immunol 174:6540\u20136545","journal-title":"J Immunol"},{"key":"828_CR22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/gepi.20092","volume":"29","author":"Z Liu","year":"2005","unstructured":"Liu Z, Lin S (2005) Multilocus LD measure and tagging SNP selection with generalized mutual information. Genet Epidemiol 29:353\u2013364","journal-title":"Genet Epidemiol"},{"key":"828_CR23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0015-0282(01)02964-8","volume":"77","author":"N Maeda","year":"2002","unstructured":"Maeda N, Izumiya C, Yamamoto Y, Oguri H, Kusume T, Fukaya T (2002) Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis. Fertil Steril 77:297\u2013302","journal-title":"Fertil Steril"},{"key":"828_CR24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1471-4914(03)00051-0","volume":"9","author":"G Matarese","year":"2003","unstructured":"Matarese G, De Placido G, Nikas Y, Alviggi C (2003) Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease? Trends Mol Med 9:223\u2013228","journal-title":"Trends Mol Med"},{"key":"828_CR25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2567.2009.03208.x","volume":"129","author":"D Middleton","year":"2010","unstructured":"Middleton D, Gonzelez F (2010) The extensive polymorphism of KIR genes. Immunology 129:8\u201319","journal-title":"Immunology"},{"key":"828_CR26","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/humupd\/dmn016","volume":"14","author":"GW Montgomery","year":"2008","unstructured":"Montgomery GW, Nyholt DR, Zhao ZZ, Treloar SA, Painter JN, Missmer SA (2008) The search for genes contributing to endometriosis risk. Hum Reprod Update 14:447\u2013457","journal-title":"Hum Reprod Update"},{"key":"828_CR27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1073\/pnas.1413453112","volume":"112","author":"A Nakimuli","year":"2015","unstructured":"Nakimuli A, Chazara O, Hiby SE et al (2015) A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia. PNAS 112:845\u2013850","journal-title":"PNAS"},{"key":"828_CR28","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.gene.2013.06.015","volume":"527","author":"W Niepiek\u0142o-Miniewska","year":"2013","unstructured":"Niepiek\u0142o-Miniewska W, Majorczyk E, Matusiak \u0141 et al (2013) Protective effect of the KIR2DS1 gene in atopic dermatitis. Gene 527:594\u2013600","journal-title":"Gene"},{"key":"828_CR29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF03195699","volume":"50","author":"I Nowak","year":"2009","unstructured":"Nowak I, Malinowski A, Tch\u00f3rzewski H et al (2009) Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion. J Appl Genet 50:391\u2013398","journal-title":"J Appl Genet"},{"key":"828_CR30","doi-asserted-by":"crossref","first-page":"e12381","DOI":"10.1371\/journal.pone.0012381","volume":"5","author":"I Nowak","year":"2010","unstructured":"Nowak I, Majorczyk E, Wi\u015bniewski A et al (2010) Does the KIR2DS5 gene protect from some human diseases? PLoS One 5:e12381","journal-title":"PLoS One"},{"key":"828_CR31","doi-asserted-by":"crossref","first-page":"e44718","DOI":"10.1371\/journal.pone.0044718","volume":"7","author":"I Nowak","year":"2012","unstructured":"Nowak I, Magott-Procelewska M, Kowal A et al (2012) Killer immunoglobulin-like receptor (KIR) and HLA genotypes affect the outcome of allogeneic kidney transplantation. PLoS One 7:e44718","journal-title":"PLoS One"},{"key":"828_CR32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0015-0282(16)54414-8","volume":"56","author":"DJ Oosterlynck","year":"1991","unstructured":"Oosterlynck DJ, Cornillie FJ, Waer M, Vandeputte M, Koninckx PR (1991) Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril 56:45\u201351","journal-title":"Fertil Steril"},{"key":"828_CR33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0015-0282(16)55224-8","volume":"58","author":"DJ Oosterlynck","year":"1992","unstructured":"Oosterlynck DJ, Meuleman C, Waer M, Koninckx PR (1992) The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis. Fertil Steril 58:290\u2013295","journal-title":"Fertil Steril"},{"key":"828_CR34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri1570","volume":"5","author":"P Parham","year":"2005","unstructured":"Parham P (2005) MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 5:201\u2013214","journal-title":"Nat Rev Immunol"},{"issue":"367","key":"828_CR35","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1098\/rstb.2011.0266","volume":"19","author":"P Parham","year":"2012","unstructured":"Parham P, Norman PJ, Abi-Rached L, Guethlein LA (2012) Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules. Philos Trans R Soc Lond B Biol Sci 19(367):800\u2013811","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"828_CR36","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-9378(15)30003-X","volume":"14","author":"J Sampson","year":"1927","unstructured":"Sampson J (1927) Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 14:422\u2013467","journal-title":"Am J Obstet Gynecol"},{"key":"828_CR37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.humimm.2013.11.012","volume":"75","author":"NK Steiner","year":"2014","unstructured":"Steiner NK, Dakshanamurthy S, Nguyen N, Hurley CK (2014) Allelic variation of killer cell immunoglobulin-like receptor 2DS5 impacts glycosylation altering cell surface expression levels. Hum Immunol 75:124\u2013128","journal-title":"Hum Immunol"},{"key":"828_CR38","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1399-0039.2004.00303.x","volume":"64","author":"JY Sun","year":"2004","unstructured":"Sun JY, Gaidulis L, Miller MM, Goto RM, Rodriguez R, Forman SJ, Senitzer D (2004) Development of a multiplex PCR-SSP method for killer cell immunoglobulin-like receptor genotyping. Tissue Antigens 64:462\u2013468","journal-title":"Tissue Antigens"},{"key":"828_CR39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00281-007-0077-0","volume":"29","author":"N Tariverdian","year":"2007","unstructured":"Tariverdian N, Theoharides TC, Siedentopf F, Guti\u00e9rrez G, Jeschke U, Rabinovich GA (2007) Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach. Semin Immunopathol 29:193\u2013210","journal-title":"Semin Immunopathol"},{"key":"828_CR40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.fertnstert.2012.05.031","volume":"98","author":"The Practice Committee of the American Society for Reproductive Medicine","year":"2012","unstructured":"The Practice Committee of the American Society for Reproductive Medicine (2012) Endometriosis and infertility: a committee opinion. Fertil Steril 98:591\u2013598","journal-title":"Fertil Steril"},{"key":"828_CR41","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jsgi.2006.07.005","volume":"13","author":"M Ulukus","year":"2006","unstructured":"Ulukus M, Cakmak H, Arici A (2006) The role of endometrium in endometriosis. J Soc Gynecol Investig 13:467\u2013476","journal-title":"J Soc Gynecol Investig"},{"key":"828_CR42","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.molimm.2008.04.016","volume":"45","author":"A Meer Van der","year":"2008","unstructured":"Van der Meer A, Schaap NPM, Schattenberg A, van Cranenbroek B, Tijssen HJ, Joosten I (2008) KIR2DS5 is associated with leukemia free survival after HLA identical stem cell transplantation in chronic myeloid leukemia patients. Mol Immunol 45:3631\u20133638","journal-title":"Mol Immunol"},{"key":"828_CR43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-0897.2005.00332.x","volume":"55","author":"C Zhang","year":"2006","unstructured":"Zhang C, Maeda N, Izumiya C, Yamamoto Y, Kusume T, Oguri H (2006) Killer immunoglobulin-like receptor and human leukocyte antigen expression as immunodiagnostic parameters for pelvic endometriosis. Am J Reprod Immunol 55:106\u2013114","journal-title":"Am J Reprod Immunol"}],"container-title":["Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00251-015-0828-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-015-0828-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-015-0828-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T11:03:28Z","timestamp":1566385408000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00251-015-0828-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["828"],"URL":"https:\/\/doi.org\/10.1007\/s00251-015-0828-3","relation":{},"ISSN":["0093-7711","1432-1211"],"issn-type":[{"value":"0093-7711","type":"print"},{"value":"1432-1211","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,1]]}}}